vsp, mom, l(1)G0321, l(1)G0405, verstopft
a divergent member of the cytokine class I receptor family - required for segmentation and functions in trachea specification - the ligand Unpaired, its receptor Domeless, Hop, and Stat92E Are Required in mushroom bodies for long term memory
Please see the JBrowse view of Dmel\dome for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.51
There is only one protein coding transcript and one polypeptide associated with this gene
Interacts with wdp; the interaction promotes internalization of dome and its subsequent lysosomal degradation; thereby reducing JAK/STAT signaling.
Undergoes lysosomal degradation.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\dome using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
dome expression at embryonic stage 14 is ubiquitous, but more pronounced in the pharynx, the anterior hindgut, and the posterior spiracles.
dome is expressed widely in the adult brain. It localizes to Kenyon cell bodies, where it has a punctate appearance. It is present in mushroom body cell bodies.
JBrowse - Visual display of RNA-Seq signals
View Dmel\dome in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA made from templates generated with primers directed against this gene.
Treatment of S2-derived S2-NP cells with dsRNA made from templates generated with primers directed against dome results in a 12-24-fold decrease in JAK/STAT activity.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
dome functions as a receptor of the JAK/STAT signal transduction pathway.
dome mutants display a variety of epithelial defects including fusions of denticle belts, holes in the cuticle and a failure of proventricular primordial cells to migrate into the endodermal part of the organ.
dome is required for epithelial development.
dome is involved in border follicle cell determination and migration.
dome codes for a transmembrane receptor required for all JAK/STAT functions in the embryo.
dome is a receptor of the pathway necessary for STAT activation.
Not known to correspond to any of the known lethal complementation groups in 18D-18E region.
Source for merge of: CG14226 anon-18DEb
Source for merge of: dome CG14226 l(1)G0321 l(1)G0405 l(1)G0367 l(1)G0218 l(1)G0441 l(1)G0264 l(1)G0282
