eIF-2γ, eIF-2gamma, eIF2G, eIF-2G
Please see the JBrowse view of Dmel\eIF2γ for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.42
Gene model reviewed during 5.48
Genes with CDS overlap: eIF-2gamma and Su(var)3-9 share promoter, first exon and N-terminal coding sequences (80 residues); overlapping structure not conserved outside of insects (see FBrf0189765).
Low-frequency RNA-Seq exon junction(s) not annotated.
Eukaryotic translation initiation factor 2 eIF2 is a heterotrimeric complex composed of an alpha, a beta and a gamma subunit. The factors eIF-1, eIF-2, eIF-3, TIF5/eIF-5 and methionyl-tRNAi form a multifactor complex (MFC) that may bind to the 40S ribosome.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\eIF2γ using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
The major 2.0 kb transcript is detected in all developmental stages by Northern blot. A minor 2.4 kb transcript is detected at 3-9 hr of embryogenesis.
JBrowse - Visual display of RNA-Seq signals
View Dmel\eIF2γ in JBrowse3-56
3-55.8
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Haplolethal locus.
The CG6476 annotation has been split into two CG43664 (which corresponds to Su(var)3-9) and CG43665 (which corresponds to eIF-2γ) in release 5.43 of the genome annotation.
The genomic region around Su(var)3-9 encodes two classes of transcript (2.4kb and 2.0kb), which show a 330bp overlap at their 5' ends, producing an overlap of 80 amino acids at the N-terminal ends of the encoded proteins. The encoded proteins are otherwise different in sequence. The 2.4kb transcript encodes Su(var)3-9 and the 2.0kb transcript encodes eIF-2γ.
Source for identity of: eIF2γ eIF-2γ
