FlyBase Gene Report: Dmel\Pde1c

General Information

Symbol

Dmel\Pde1c

Species

D. melanogaster

Name

Phosphodiesterase 1c

Annotation Symbol

CG44007

Feature Type

protein_coding_gene

FlyBase ID

FBgn0264815

Gene Model Status

Current

Stock Availability

57 publicly available

Enzyme Name (EC)

3',5'-cyclic-nucleotide phosphodiesterase (3.1.4.17)

3',5'-cyclic-GMP phosphodiesterase (3.1.4.35)

3',5'-cyclic-AMP phosphodiesterase (3.1.4.53)

Gene Summary

Cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:15673286). Required for male fertility and male mating behavior (PubMed:20551439). (UniProt, B7YZV4)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

33A2-33B1

Sequence location

2L:11,814,156..11,928,572 [-]

Recombination map

2-45

RefSeq locus

NT_033779 REGION:11814156..11928572

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (13 terms)

Molecular Function (6 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

enables 3',5'-cyclic-AMP phosphodiesterase activity

inferred from direct assay

(Day, 2005)

enables 3',5'-cyclic-GMP phosphodiesterase activity

inferred from direct assay

(Day, 2005)

enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity

inferred from direct assay

(Day, 2005)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables 3',5'-cyclic-nucleotide phosphodiesterase activity

inferred from electronic annotation with InterPro:IPR002073, InterPro:IPR036971

(InterPro Project Members, 2004-)

enables calmodulin binding

inferred from sequence model

(Day, 2005)

enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity

inferred from biological aspect of ancestor with PANTHER:PTN008516278

(GO Reference Genome Project, 2011-)

enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity

inferred from biological aspect of ancestor with PANTHER:PTN008516278

(GO Reference Genome Project, 2011-)

Biological Process (6 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in cAMP metabolic process

inferred from direct assay

(Day, 2005)

involved_in cGMP metabolic process

inferred from direct assay

(Day, 2005)

involved_in male mating behavior

inferred from mutant phenotype

(Morton et al., 2010)

involved_in sexual reproduction

inferred from high throughput expression pattern

(Findlay et al., 2008)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in cAMP-mediated signaling

inferred from biological aspect of ancestor with PANTHER:PTN001682918

(GO Reference Genome Project, 2011-)

involved_in signal transduction

inferred from electronic annotation with InterPro:IPR002073, InterPro:IPR036971

(InterPro Project Members, 2004-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in extracellular space

inferred from high throughput direct assay

(Findlay et al., 2008)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES

Protein Family (UniProt)

Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily. (B7YZV4)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

3',5'-cyclic-GMP phosphodiesterase activity

3',5'-cyclic GMP + H2O = GMP + H(+) (3.1.4.35)

RHEA 16957: 3',5'-cyclic-nucleotide phosphodiesterase activity

a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+) (3.1.4.17)

RHEA 14653: 3',5'-cyclic-AMP phosphodiesterase activity

3',5'-cyclic AMP + H2O = AMP + H(+) (3.1.4.53)

RHEA 25277:

Summaries

Gene Group (FlyBase)

CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES -: Cyclic-nucleotide phosphodiesterases are hydrolases that catalyze the hydrolysis of a nucleoside cyclic phosphate into a nucleoside phosphate.

Protein Function (UniProtKB)

(UniProt, B7YZV4)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Pde1c for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry B7YZV4)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.53

Gene model reviewed during 5.47

Gene model reviewed during 5.56

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Low-frequency RNA-Seq exon junction(s) not annotated.

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Sequence Ontology: Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012, Graveley et al., 2011)

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Pde1c-RB

FBtr0334136

NM_001144344

3862

834

Pde1c-RC

FBtr0334137

NM_135676

4561

605

Pde1c-RD

FBtr0334139

NM_001144346

4203

1137

Pde1c-RE

FBtr0334138

NM_001144345

5563

1173

Pde1c-RG

FBtr0334140

NM_001144348

5704

834

Pde1c-RH

FBtr0334135

NM_001259065

4703

952

Pde1c-RJ

FBtr0334141

NM_001273466

5321

1158

Pde1c-RK

FBtr0334142

NM_001144347

5071

1009

Pde1c-RL

FBtr0344148

NM_001259066

4894

855

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Pde1c-PB

FBpp0306253

91.5

834

5.43

FBpp0306254

67.7

605

5.62

FBpp0306256

120.8

1137

6.22

FBpp0306255

124.8

1173

5.80

FBpp0306257

91.5

834

5.43

FBpp0306252

101.9

952

6.04

FBpp0306258

122.9

1158

6.17

FBpp0306259

108.0

1009

5.46

FBpp0310561

93.6

855

5.37

X2BZJ7

NP_001245995

AFH03669

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

834 aa isoforms: Pde1c-PB, Pde1c-PG

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pde1c using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.42

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 11 -- 12

procrystal cell

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic/larval crystal cell

(Fisher et al., 2012)

embryonic/larval lymph gland

(Fisher et al., 2012)

ventral midline of embryo

(Fisher et al., 2012)

larval midline neuron

(Kearney et al., 2004)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in extracellular space

inferred from high throughput direct assay

(Findlay et al., 2008)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Pde1c in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Pde1c

View exonic expression by tissue for Dmel\Pde1c

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0264815

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34594/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0264815

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0259225

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0264815

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 29 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 14 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Pde1c

Transgenic constructs containing regulatory region of Pde1c

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(2L)Exel6030

(Morton et al., 2010, Ryder, 2004.4.26)

Gene partially disrupted in

Df(2L)CycY^E8

(Liu and Finley, 2010)

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

Pde1c^GD5528

Sterility

Allele

fertile

male sterile (with Df(2L)Exel6030)

Pde1c^c04487

male sterile | recessive

Pde1c^c04487

Other Phenotypes

Allele

abnormal pain response | adult stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Pde1c^GD5528

flightless, with Scer\GAL4^Mef2.PR

Pde1c^GD10358

short lived | heat sensitive, with Scer\GAL4^tin.CΔ4

Pde1c^GD5528

visible, with Scer\GAL4^pnr-MD237

Pde1c^GD10358

Phenotype manifest in

Allele

myofibril, with Scer\GAL4^Mef2.PR

Pde1c^GD10358

trichogen cell, with Scer\GAL4^pnr-MD237

Pde1c^GD10358

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (21)

Hsap\PDE1A

11 of 14

Yes

Hsap\PDE1B

10 of 14

Yes

Hsap\PDE1C

10 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (21)

Rnor\Pde1a

11 of 14

Yes

Rnor\Pde1b

10 of 14

Yes

Rnor\Pde1c

10 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Mus musculus (laboratory mouse) (21)

Mmus\Pde1a

11 of 14

Yes

Mmus\Pde1b

10 of 14

Yes

Mmus\Pde1c

10 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (22)

Xtro\pde1a

7 of 13

Yes

Xtro\pde1b

7 of 13

Yes

Xtro\pde1c

7 of 13

Yes

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Yes

2 of 13

2 of 13

1 of 13

1 of 13

Yes

Xtro\pde3b

1 of 13

Yes

Xtro\pde6c

1 of 13

Xtro\pde7a

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (27)

Drer\pde1a

11 of 14

Yes

Drer\pde1cb

10 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Drer\si:dkey-219c10.4

2 of 14

Drer\pde1ca

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (6)

Cele\pde-1

10 of 14

Yes

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Anopheles gambiae (African malaria mosquito) (8)

Agam\AgaP_AGAP008967

9 of 12

Yes

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\PDE2

3 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Pde1c. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (5)

dnc

6 of 13

5 of 13

5 of 13

5 of 13

5 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

PDE1C; phosphodiesterase 1C

model of autosomal dominant nonsyndromic deafness 74

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

Pde1c^c04487

ameliorates nervous system disease

modeled by Atpα^CJ5

(Talsma et al., 2014)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PDE1A; phosphodiesterase 1A

11 of 14

171890

PDE1B; phosphodiesterase 1B

10 of 14

171891

PDE1C; phosphodiesterase 1C

10 of 14

602987

DEAFNESS, AUTOSOMAL DOMINANT 74; DFNA74

autosomal dominant nonsyndromic deafness 74

PDE4A; phosphodiesterase 4A

3 of 14

600126

PDE4B; phosphodiesterase 4B

3 of 14

600127

PDE4C; phosphodiesterase 4C

3 of 14

600128

PDE4D; phosphodiesterase 4D

3 of 14

600129

ACRODYSOSTOSIS 2 WITH OR WITHOUT HORMONE RESISTANCE; ACRDYS2

acrodysostosis

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Other Interaction Browsers

Summary of Genetic Interactions

esyN Network Diagram

Other Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0264815

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-45

Cytogenetic map

33A2-33B1

Sequence location

2L:11,814,156..11,928,572 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

33A2-33B1

Limits computationally determined from genome sequence between P{PZ}crol⁰⁴⁴¹⁸&P{EP}crol^EP1183 and P{EP}MESK1^EP980

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-45

(FlyBase, 2016)

2-38.9

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (57)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

93120

w^*; P{UAS-Pde1c.RC}3

93119

w^*; P{Pde1c-GAL4.RC}3

38837

w¹¹¹⁸; P{GMR52E12-GAL4}attP2

38859

w¹¹¹⁸; P{GMR53A05-GAL4}attP2

52827

w¹¹¹⁸; P{GMR52E12-lexA}attP40

69144

w¹¹¹⁸; P{R53A05-GAL4.DBD}attP2

18551

w¹¹¹⁸; PBac{WH}Pde1c^f02409

Korea

15530

P{GMR53A10-GAL4}attP2

15972

P{GMR53A10-lexA}JK22C

15973

P{GMR53A10-lexA}JK73A

VDRC

v101906

P{KK110196}VIE-260B

v108981

P{KK107045}VIE-260B

More stocks available...

Genomic Clones (81)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (20)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0264815

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Source for merge of: Pde1c CG14943 CG14944 CG31757 CG31758

(FlyBase Genome Annotators, 2008)

Additional comments

Annotation CG42325 split in release 5.47 of the genome annotation; split supported by EST and RNASeq coverage data. An exon of CG42325 has been made into a distinct annotation, CG44008; CG44008 is a reinstatement of CG31758 from release 5.2. The remainder of CG42325 forms the CG44007 annotation, and retains the function and name (Pde1c) of CG42325.

(FlyBase Genome Annotators, 2012)

Annotations CG14940, CG14943, CG14944, CG31757 and CG31758 merged as CG42325 in release 5.9 of the genome annotation.

(FlyBase Genome Annotators, 2008)

Annotation CG14942 split into CG31757 and CG31758 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Nomenclature History

Source for database identify of

Source for identity of: Pde1c CG14940

(Day and Davies, 2003.6.10)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (14)

Reported As

Symbol Synonym

CG14940

(Perkins et al., 2009, Day, 2005)

CG14942

CG14943

CG14944

(Keleman et al., 2009.8.5)

CG31757

(Japanese National Institute of Genetics, 2012.5.21, Keleman et al., 2009.8.5, Burnette et al., 2005)

CG31758

(Findlay et al., 2009, Keleman et al., 2009.8.5, Findlay et al., 2008, Riedl et al., 2005)

CG42325

(FlyBase Genome Annotators, 2008)

CG44007

(National Institute of Genetics Fly Stocks, 2023-, National Institute of Genetics Fly Stocks, 2022-, Ni et al., 2010.12.1)

PDE1

(Davies et al., 2014)

PDE1C

(Day, 2005)

PDE1c

(Song et al., 2017, Clemens-Grisham et al., 2008, Day and Davies, 2003.6.10)

mdcds_1440

(Chen and Oliver, 2014.8.15)

Name Synonyms

CG14943

CG14944

CG31757

CG31758

CG42325

(FlyBase Genome Annotators, 2008)

Phosphodiesterase 1c

(Garlovsky et al., 2022, Day and Davies, 2003.6.10)

Secondary FlyBase IDs

FBgn0032383
FBgn0032384
FBgn0032380
FBgn0051758
FBgn0259225
FBgn0032379
FBgn0051757
FBgn0264749

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 80 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

34594

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

B7YZV4

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

B7YZV4

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

B7YZV4

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0264815

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34594/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0264815

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0264815

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG44007

MARRVEL_MODEL - MARRVEL (model organism gene)

34594

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0264815

DroID - A comprehensive database of gene and protein interactions.

FBgn0264815

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0259225

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0264815

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0264815

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (99)

The following external sites may use different assemblies or annotations than FlyBase.

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