larval proprioception - defensive response to mechanical stimuli - Tmc cells undergo restructuring engendering an enhanced response to touching in females following mating - critical for sensing subtle differences in substrate stiffness during ovoposition - required for sensing two key textural features of food-hardness and viscosity - presumably activated by membrane curvature in dendrites that are exposed to strain
Please see the JBrowse view of Dmel\Tmc for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 6.02
Alternative transcript with retained intron postulated (between exons 4 and 5 of transcript -RA; FBrf0180668).
Gene model reviewed during 6.04
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Tmc using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\Tmc in JBrowse3-31
3-23.6
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Tmc is required for sensing the hardness and viscosity of food.
Source for merge of: CG14177 CG3280
Annotations CG14177 and CG3280 merged as CG46121 in release 6.03 of the genome annotation. Merge supported by RNA-Seq coverage and exon junction data.
Source for identity of: Tmc CG46121
Named 'Transmembrane channel-like' (Tmc) after the mammalian orthologs.