FB2024_03 , released June 25, 2024
Human Disease Model Report: high-fat diet, cardiomyopathy
Open Close
General Information
Name
high-fat diet, cardiomyopathy
FlyBase ID
FBhh0000483
Disease Ontology Term
Parent Disease
OMIM
Overview

Wild-type adult flies fed a high-fat diet, HFD, (post-eclosion) have increased levels of fat, glucose, and insulin-like peptides. Within the heart, myofibrillar disorganization within the cardiomyocytes, cardiac lipid accumulation, reduced cardiac contractility, conduction blocks, and severe structural pathologies are observed. Ameliorating effects, based on inhibition or increase of components of affected cellular pathways, have been investigated. Exercise has been found to restore HFD-induced cardiac dysfunction.

[updated May 2022 by FlyBase; FBrf0222196]

Disease Summary Information
Disease Summary: high-fat diet, cardiomyopathy
OMIM report
Human gene(s) implicated
Symptoms and phenotype
Genetics
Cellular phenotype and pathology
Molecular information
External links
    Disease synonyms
    cardiac lipotoxicity
    cardiomyopathy, diet-induced, high fat
    lipotoxic cardiomyopathy
    obesity-associated heart dysfunction
    Ortholog Information
    Human gene(s) in FlyBase
      Other mammalian ortholog(s) used
        D. melanogaster Gene Information (0)
        Other Genes Used: Viral, Bacterial, Synthetic (0)
          Summary of Physical Interactions (0 groups)
          Alleles Reported to Model Human Disease (Disease Ontology) (0 alleles)
          Alleles Representing Disease-Implicated Variants
          Genetic Tools, Stocks and Reagents
          Sources of Stocks
          Contact lab of origin for a reagent not available from a public stock center.
          Bloomington Stock Center Disease Page
          Related mammalian, viral, bacterial, or synthetic transgenes
          Allele
          Transgene
          Publicly Available Stocks
          Selected Drosophila transgenes
          Allele
          Transgene
          Publicly Available Stocks
          RNAi constructs available
          Allele
          Transgene
          Publicly Available Stocks
          Selected Drosophila classical alleles
          Allele
          Allele class
          Mutagen
          Publicly Available Stocks
          References (33)