Human Disease Model Report: Epstein-Barr virus infection

General Information

Name

Epstein-Barr virus infection

FlyBase ID

FBhh0000598

Disease Ontology Term

viral infectious disease

Parent Disease

OMIM

Overview

Drosophila has been used to model Epstein-Barr virus (EBV) infection, a common DNA virus of the herpes family. Although most people get infected with EBV at some point in their lives, it can cause several diseases, including infectious mononucleosis and some forms of cancer.

EBV DNA, when injected into young Drosophila adults, induces the fly immune deficiency (IMD) pathway, which controls the expression of most of the antimicrobial peptides in Drosophila. It is postulated that this IMD response is analogous to the enhanced expression of tumor necrosis factor-α observed in mice exposed to EBV DNA. This system has been used to investigate the possible role of EBV in prolonged inflammation of the digestive tract, such as in inflammatory bowel disease.

The viral lytic cascade of of Epstein-Barr virus (EBV) is induced by the two immediate early genes BZLF1 and BRLF1, which cooperate to induce expression of all downstream lytic genes. Drosophila models of Epstein-Barr virus infection have been created by introducing transgenic constructs of BRLF1 and BZLF1 (EBV\BRLF1, sometimes referred to as "R" and EBV\BZLF1, sometimes referred to as "Z"). These fly models have been used to study the interactions between host cellular proteins and the introduced BZLF1 and BRLF1 genes.

[updated Apr. 2021 by FlyBase; FBrf0222196]

Disease Summary Information

Disease Summary: Epstein-Barr virus infection

OMIM report

Human gene(s) implicated

Symptoms and phenotype

Epstein-Barr virus (EBV), also known as human herpesvirus 4 (HHV-4), is a member of the herpes DNA virus family. It is one of the most common human viruses; most people get infected with EBV at some point in their lives. EBV spreads most commonly through bodily fluids, primarily saliva. EBV is associated with several diseases, including infectious mononucleosis and some forms of cancer. [https://www.cdc.gov/epstein-barr/about-ebv.html; http://www.cancerresearchuk.org/about-cancer/causes-of-cancer/infections-hpv-and-cancer/ebv-and-cancer]

(FlyBase Curators, 2013-)

Genetics

The Epstein-Barr viral lytic cascade is induced by the two immediate early genes BZLF1 and BRLF1, which cooperate to induce expression of all downstream lytic genes (Hutt-Fletcher, 2016; pubmed:27795426).

(FlyBase Curators, 2013-)

Cellular phenotype and pathology

Molecular information

External links

Disease synonyms

EBV infection

Epstein-Barr viral infection

Related Diseases

Related human health report(s)

infection by viral pathogens

Ortholog Information

Human gene(s) in FlyBase

Other mammalian ortholog(s) used

D. melanogaster Gene Information (0)

Other Genes Used: Viral, Bacterial, Synthetic (2)

Summary of Physical Interactions (0 groups)

Alleles Reported to Model Human Disease (Disease Ontology) (3 alleles)

EBV\BZLF1

Models Based on Experimental Evidence ( 2 )

Allele

Disease

Evidence

References

EBV\BZLF1^GMR.PA

model of viral infectious disease

CEA

(Adamson et al., 2005)

model of infectious mononucleosis

CEA

(Adamson et al., 2005)

model of Epstein-Barr virus hepatitis

CEA

(Adamson et al., 2005)

EBV\BZLF1^Z311.GMR

model of viral infectious disease

CEA

(Adamson et al., 2005)

model of infectious mononucleosis

CEA

(Adamson et al., 2005)

model of Epstein-Barr virus hepatitis

CEA

(Adamson et al., 2005)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

EBV\BZLF1^GMR.PA

model of Epstein-Barr virus hepatitis

is ameliorated by l(2)gd1^EY04750

(Adamson and Lajeunesse, 2012)

is ameliorated by 14-3-3ε^S-696

(Adamson and Lajeunesse, 2012)

is ameliorated by hyd¹⁵

(Adamson and Lajeunesse, 2012)

is exacerbated by mTor^ΔP

(Adamson et al., 2014, Adamson and Lajeunesse, 2012)

is exacerbated by Ras85D^e1B

(Adamson and Lajeunesse, 2012)

is exacerbated by mTor^k17004

(Adamson et al., 2014, Adamson and Lajeunesse, 2012)

is exacerbated by rpr^GMR.PH

(Adamson and Lajeunesse, 2012)

is exacerbated by p53^GMR.Ex

(Adamson and Lajeunesse, 2012)

is exacerbated by ago^EY01092

(Adamson and Lajeunesse, 2012)

is exacerbated by dlg1^G0276

(Adamson and Lajeunesse, 2012)

is exacerbated by Rab5^KG05684

(Adamson and Lajeunesse, 2012)

model of infectious mononucleosis

is ameliorated by 14-3-3ε^S-696

(Adamson and Lajeunesse, 2012)

is ameliorated by l(2)gd1^EY04750

(Adamson and Lajeunesse, 2012)

is ameliorated by hyd¹⁵

(Adamson and Lajeunesse, 2012)

is exacerbated by mTor^ΔP

(Adamson et al., 2014, Adamson and Lajeunesse, 2012)

is exacerbated by Ras85D^e1B

(Adamson and Lajeunesse, 2012)

is exacerbated by mTor^k17004

(Adamson et al., 2014, Adamson and Lajeunesse, 2012)

is exacerbated by rpr^GMR.PH

(Adamson and Lajeunesse, 2012)

is exacerbated by p53^GMR.Ex

(Adamson and Lajeunesse, 2012)

is exacerbated by ago^EY01092

(Adamson and Lajeunesse, 2012)

is exacerbated by dlg1^G0276

(Adamson and Lajeunesse, 2012)

is exacerbated by Rab5^KG05684

(Adamson and Lajeunesse, 2012)

model of viral infectious disease

is ameliorated by l(2)gd1^EY04750

(Adamson and Lajeunesse, 2012)

is ameliorated by 14-3-3ε^S-696

(Adamson and Lajeunesse, 2012)

is ameliorated by hyd¹⁵

(Adamson and Lajeunesse, 2012)

is exacerbated by mTor^ΔP

(Adamson et al., 2014, Adamson and Lajeunesse, 2012)

is exacerbated by mTor^k17004

(Adamson et al., 2014, Adamson and Lajeunesse, 2012)

is exacerbated by rpr^GMR.PH

(Adamson and Lajeunesse, 2012)

is exacerbated by Ras85D^e1B

(Adamson and Lajeunesse, 2012)

is exacerbated by p53^GMR.Ex

(Adamson and Lajeunesse, 2012)

is exacerbated by dlg1^G0276

(Adamson and Lajeunesse, 2012)

is exacerbated by Rab5^KG05684

(Adamson and Lajeunesse, 2012)

is exacerbated by ago^EY01092

(Adamson and Lajeunesse, 2012)

EBV\BRLF1

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

EBV\BRLF1^GMR.PA

model of viral infectious disease

CEA

(Adamson and Lajeunesse, 2012)

model of infectious mononucleosis

CEA

(Adamson and Lajeunesse, 2012)

model of Epstein-Barr virus hepatitis

CEA

(Adamson and Lajeunesse, 2012)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

EBV\BRLF1^GMR.PA

model of viral infectious disease

is exacerbated by gek^unspecified

(Adamson and Lajeunesse, 2012)

is exacerbated by TBPH^unspecified

(Adamson and Lajeunesse, 2012)

is exacerbated by Shrm^unspecified

(Adamson and Lajeunesse, 2012)

is exacerbated by RhoGEF2^unspecified

(Adamson and Lajeunesse, 2012)

is exacerbated by chic^unspecified

(Adamson and Lajeunesse, 2012)

is exacerbated by Pen^unspecified

(Adamson and Lajeunesse, 2012)

is exacerbated by Chi^unspecified

(Adamson and Lajeunesse, 2012)

is exacerbated by NAT1^unspecified

(Adamson and Lajeunesse, 2012)

is exacerbated by Fs(2)Ket^unspecified

(Adamson and Lajeunesse, 2012)

is exacerbated by CG16896^unspecified

(Adamson and Lajeunesse, 2012)

is exacerbated by CdGAPr^unspecified

(Adamson and Lajeunesse, 2012)

is exacerbated by Cdc14^unspecified

(Adamson and Lajeunesse, 2012)

is exacerbated by bin3^unspecified

(Adamson and Lajeunesse, 2012)

is ameliorated by Rack1^unspecified

(Adamson and Lajeunesse, 2012)

is ameliorated by RanBPM^unspecified

(Adamson and Lajeunesse, 2012)

is exacerbated by AP-2α^unspecified

(Adamson and Lajeunesse, 2012)

is exacerbated by Acaa^unspecified

(Adamson and Lajeunesse, 2012)

is ameliorated by Pax^unspecified

(Adamson and Lajeunesse, 2012)

is ameliorated by dve^unspecified

(Adamson and Lajeunesse, 2012)

is exacerbated by RN-tre^unspecified

(Adamson and Lajeunesse, 2012)

is ameliorated by dap^GMR.PU

(Adamson and Lajeunesse, 2012)

is ameliorated by βCOP^unspecified

(Adamson and Lajeunesse, 2012)

is ameliorated by chico^KG00032

(Adamson and Lajeunesse, 2012)

is ameliorated by awd^j2A4

(Adamson and Lajeunesse, 2012)

is ameliorated by scrib^j7B3

(Adamson and Lajeunesse, 2012)

is ameliorated by Rbf^GMR.PU

(Adamson and Lajeunesse, 2012)

is ameliorated by p53^GMR.Ex

(Adamson and Lajeunesse, 2012)

is ameliorated by mTor^ΔP

(Adamson et al., 2014, Adamson and Lajeunesse, 2012)

is exacerbated by Rab5^EY10619

(Adamson and Lajeunesse, 2012)

is exacerbated by Mer⁴

(Adamson and Lajeunesse, 2012)

is ameliorated by mTor^k17004

(Adamson et al., 2014, Adamson and Lajeunesse, 2012)

is ameliorated by rpr^GMR.PH

(Adamson and Lajeunesse, 2012)

is exacerbated by InR^E19

(Adamson and Lajeunesse, 2012)

is exacerbated by E2f1^GMR.PU

(Adamson and Lajeunesse, 2012)

is exacerbated by Csk^c04256

(Adamson and Lajeunesse, 2012)

is exacerbated by brat^k06028

(Adamson and Lajeunesse, 2012)

is exacerbated by 14-3-3ζ^P1375

(Adamson and Lajeunesse, 2012)

is exacerbated by brat¹

(Adamson and Lajeunesse, 2012)

is exacerbated by 14-3-3ζ^unspecified

(Adamson and Lajeunesse, 2012)

model of infectious mononucleosis

is exacerbated by TBPH^unspecified

(Adamson and Lajeunesse, 2012)

is exacerbated by Shrm^unspecified

(Adamson and Lajeunesse, 2012)

is exacerbated by RhoGEF2^unspecified

(Adamson and Lajeunesse, 2012)

is exacerbated by gek^unspecified

(Adamson and Lajeunesse, 2012)

is exacerbated by chic^unspecified

(Adamson and Lajeunesse, 2012)

is exacerbated by Pen^unspecified

(Adamson and Lajeunesse, 2012)

is exacerbated by NAT1^unspecified

(Adamson and Lajeunesse, 2012)

is exacerbated by CG16896^unspecified

(Adamson and Lajeunesse, 2012)

is exacerbated by Fs(2)Ket^unspecified

(Adamson and Lajeunesse, 2012)

is exacerbated by Chi^unspecified

(Adamson and Lajeunesse, 2012)

is exacerbated by CdGAPr^unspecified

(Adamson and Lajeunesse, 2012)

is exacerbated by Cdc14^unspecified

(Adamson and Lajeunesse, 2012)

is exacerbated by bin3^unspecified

(Adamson and Lajeunesse, 2012)

is ameliorated by RanBPM^unspecified

(Adamson and Lajeunesse, 2012)

is exacerbated by AP-2α^unspecified

(Adamson and Lajeunesse, 2012)

is exacerbated by Acaa^unspecified

(Adamson and Lajeunesse, 2012)

is ameliorated by Rack1^unspecified

(Adamson and Lajeunesse, 2012)

is ameliorated by Pax^unspecified

(Adamson and Lajeunesse, 2012)

is exacerbated by RN-tre^unspecified

(Adamson and Lajeunesse, 2012)

is ameliorated by dve^unspecified

(Adamson and Lajeunesse, 2012)

is ameliorated by Rbf^GMR.PU

(Adamson and Lajeunesse, 2012)

is ameliorated by βCOP^unspecified

(Adamson and Lajeunesse, 2012)

is ameliorated by dap^GMR.PU

(Adamson and Lajeunesse, 2012)

is ameliorated by chico^KG00032

(Adamson and Lajeunesse, 2012)

is ameliorated by awd^j2A4

(Adamson and Lajeunesse, 2012)

is ameliorated by scrib^j7B3

(Adamson and Lajeunesse, 2012)

is ameliorated by mTor^ΔP

(Adamson et al., 2014, Adamson and Lajeunesse, 2012)

is exacerbated by Rab5^EY10619

(Adamson and Lajeunesse, 2012)

is exacerbated by Mer⁴

(Adamson and Lajeunesse, 2012)

is ameliorated by mTor^k17004

(Adamson et al., 2014, Adamson and Lajeunesse, 2012)

is ameliorated by p53^GMR.Ex

(Adamson and Lajeunesse, 2012)

is ameliorated by rpr^GMR.PH

(Adamson and Lajeunesse, 2012)

is exacerbated by InR^E19

(Adamson and Lajeunesse, 2012)

is exacerbated by 14-3-3ζ^P1375

(Adamson and Lajeunesse, 2012)

is exacerbated by E2f1^GMR.PU

(Adamson and Lajeunesse, 2012)

is exacerbated by Csk^c04256

(Adamson and Lajeunesse, 2012)

is exacerbated by brat¹

(Adamson and Lajeunesse, 2012)

is exacerbated by brat^k06028

(Adamson and Lajeunesse, 2012)

is exacerbated by 14-3-3ζ^unspecified

(Adamson and Lajeunesse, 2012)

model of Epstein-Barr virus hepatitis

is exacerbated by TBPH^unspecified

(Adamson and Lajeunesse, 2012)

is exacerbated by Shrm^unspecified

(Adamson and Lajeunesse, 2012)

is exacerbated by gek^unspecified

(Adamson and Lajeunesse, 2012)

is exacerbated by RhoGEF2^unspecified

(Adamson and Lajeunesse, 2012)

is exacerbated by Pen^unspecified

(Adamson and Lajeunesse, 2012)

is exacerbated by NAT1^unspecified

(Adamson and Lajeunesse, 2012)

is exacerbated by chic^unspecified

(Adamson and Lajeunesse, 2012)

is exacerbated by CG16896^unspecified

(Adamson and Lajeunesse, 2012)

is exacerbated by Fs(2)Ket^unspecified

(Adamson and Lajeunesse, 2012)

is exacerbated by Chi^unspecified

(Adamson and Lajeunesse, 2012)

is exacerbated by CdGAPr^unspecified

(Adamson and Lajeunesse, 2012)

is ameliorated by RanBPM^unspecified

(Adamson and Lajeunesse, 2012)

is exacerbated by Cdc14^unspecified

(Adamson and Lajeunesse, 2012)

is exacerbated by bin3^unspecified

(Adamson and Lajeunesse, 2012)

is exacerbated by AP-2α^unspecified

(Adamson and Lajeunesse, 2012)

is ameliorated by Rack1^unspecified

(Adamson and Lajeunesse, 2012)

is ameliorated by Pax^unspecified

(Adamson and Lajeunesse, 2012)

is exacerbated by Acaa^unspecified

(Adamson and Lajeunesse, 2012)

is exacerbated by RN-tre^unspecified

(Adamson and Lajeunesse, 2012)

is ameliorated by dve^unspecified

(Adamson and Lajeunesse, 2012)

is ameliorated by Rbf^GMR.PU

(Adamson and Lajeunesse, 2012)

is ameliorated by dap^GMR.PU

(Adamson and Lajeunesse, 2012)

is ameliorated by βCOP^unspecified

(Adamson and Lajeunesse, 2012)

is ameliorated by mTor^ΔP

(Adamson et al., 2014, Adamson and Lajeunesse, 2012)

is ameliorated by chico^KG00032

(Adamson and Lajeunesse, 2012)

is ameliorated by scrib^j7B3

(Adamson and Lajeunesse, 2012)

is ameliorated by awd^j2A4

(Adamson and Lajeunesse, 2012)

is ameliorated by p53^GMR.Ex

(Adamson and Lajeunesse, 2012)

is exacerbated by Rab5^EY10619

(Adamson and Lajeunesse, 2012)

is ameliorated by mTor^k17004

(Adamson et al., 2014, Adamson and Lajeunesse, 2012)

is exacerbated by Mer⁴

(Adamson and Lajeunesse, 2012)

is exacerbated by InR^E19

(Adamson and Lajeunesse, 2012)

is ameliorated by rpr^GMR.PH

(Adamson and Lajeunesse, 2012)

is exacerbated by E2f1^GMR.PU

(Adamson and Lajeunesse, 2012)

is exacerbated by brat¹

(Adamson and Lajeunesse, 2012)

is exacerbated by 14-3-3ζ^P1375

(Adamson and Lajeunesse, 2012)

is exacerbated by brat^k06028

(Adamson and Lajeunesse, 2012)

is exacerbated by Csk^c04256

(Adamson and Lajeunesse, 2012)

is exacerbated by 14-3-3ζ^unspecified

(Adamson and Lajeunesse, 2012)

Alleles Representing Disease-Implicated Variants

Genetic Tools, Stocks and Reagents

Sources of Stocks

Contact lab of origin for a reagent not available from a public stock center.

Bloomington Stock Center Disease Page

Related mammalian, viral, bacterial, or synthetic transgenes

Allele

Transgene

Publicly Available Stocks

Selected Drosophila transgenes

Allele

Transgene

Publicly Available Stocks

RNAi constructs available

Allele

Transgene

Publicly Available Stocks

Selected Drosophila classical alleles

Allele

Allele class

Mutagen

Publicly Available Stocks

References (12)

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