FB2024_04 , released June 25, 2024
Human Disease Model Report: kidney disease (fly models overview)
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General Information
Name
kidney disease (fly models overview)
FlyBase ID
FBhh0000738
Disease Ontology Term
Parent Disease
OMIM
Overview

This report includes links to reviews and general information on fly models of kidney disease. In vertebrates, kidneys are major organs of detoxification, excreting catabolites and toxins; they also maintain overall fluid and electrolyte balance. In insects, these functions are carried out by Malpighian tubules and nephrocytes.

References describing biology of this Drosophila system, methods and assays: Miller, et al., 2013 (FBrf0222987); Ugur, et al., 2016 (FBrf0231139); Gautam, et al., 2017 (FBrf0235307); Helmstadter and Simons, 2017 (FBrf0235870); Millet-Boureima, et al., 2018 (FBrf0239301); Odenthal and Brinkkoetter, 2019 (FBrf0243383); Leemput et al., 2022 (FBrf0252906).

For a complete listing of Drosophila models of kidney disease see the FlyBase Human Disease Model Report Index (http://flybase.org/lists/FBhh/).

[updated Mar. 2022 by FlyBase; FBrf0222196]

Disease Summary Information
Disease Summary: kidney disease (fly models overview)
OMIM report
Human gene(s) implicated
Symptoms and phenotype
Genetics
Cellular phenotype and pathology
Molecular information
External links
    Disease synonyms
    kidney disease
    nephropathy
    renal disease
    Ortholog Information
    Human gene(s) in FlyBase
      Other mammalian ortholog(s) used
        D. melanogaster Gene Information (0)
        Other Genes Used: Viral, Bacterial, Synthetic (0)
          Summary of Physical Interactions (0 groups)
          Alleles Reported to Model Human Disease (Disease Ontology) (0 alleles)
          Alleles Representing Disease-Implicated Variants
          Genetic Tools, Stocks and Reagents
          Sources of Stocks
          Contact lab of origin for a reagent not available from a public stock center.
          Bloomington Stock Center Disease Page
          Related mammalian, viral, bacterial, or synthetic transgenes
          Allele
          Transgene
          Publicly Available Stocks
          Selected Drosophila transgenes
          Allele
          Transgene
          Publicly Available Stocks
          RNAi constructs available
          Allele
          Transgene
          Publicly Available Stocks
          Selected Drosophila classical alleles
          Allele
          Allele class
          Mutagen
          Publicly Available Stocks
          References (23)