This report includes links to reviews and general information on fly models of kidney disease. In vertebrates, kidneys are major organs of detoxification, excreting catabolites and toxins; they also maintain overall fluid and electrolyte balance. In insects, these functions are carried out by Malpighian tubules and nephrocytes.
References describing biology of this Drosophila system, methods and assays: Miller, et al., 2013 (FBrf0222987); Ugur, et al., 2016 (FBrf0231139); Gautam, et al., 2017 (FBrf0235307); Helmstadter and Simons, 2017 (FBrf0235870); Millet-Boureima, et al., 2018 (FBrf0239301); Odenthal and Brinkkoetter, 2019 (FBrf0243383); Leemput et al., 2022 (FBrf0252906).
For a complete listing of Drosophila models of kidney disease see the FlyBase Human Disease Model Report Index (http://flybase.org/lists/FBhh/).
[updated Mar. 2022 by FlyBase; FBrf0222196]