Human Disease Model Report: dilated cardiomyopathy, Notch signaling

General Information

Name

dilated cardiomyopathy, Notch signaling

FlyBase ID

FBhh0000740

Disease Ontology Term

dilated cardiomyopathy

Parent Disease

OMIM

Overview

A deletion screen for phenotypes of dilated cardiomyopathy, defined as enlarged end-diastolic and end-systolic dimensions, and impaired fractional shortening, was conducted in Drosophila. This resulted in the identification of a causative gene that was subsequently determined to encode a Notch ligand; the gene was given the name weary (wry). There are several low-scoring orthologs of Dmel\wry in human.

Using the GAL4/GAL80-ts system to precisely target expression in the fly adult heart, RNAi-effected loss of wry expression results in inducible and reversible dilated cardiomyopathy. Cardiac-specific expression of a transgenic wild-type copy of wry rescues the dilated cardiomyopathy phenotype of the deletion. Extending this analysis to other Notch signaling components, cardiac-specific expression of N, Dl, or Ser was also observed to rescue the dilated cardiomyopathy phenotype of the deletion.

For transgenic human constructs, fly transgenic constructs and classical alleles, detailed phenotypic descriptions can be found in the allele reports; allele reports can be accessed from the gene report or by clicking on the allele symbols in the Disease Ontology and Reagent tables below.

[updated Feb. 2018 by FlyBase; FBrf0222196]

Disease Summary Information

Disease Summary: dilated cardiomyopathy, Notch signaling

OMIM report

Human gene(s) implicated

Symptoms and phenotype

Genetics

Cellular phenotype and pathology

Molecular information

External links

Disease synonyms

Related Diseases

Related human health report(s)

cardiomyopathy

Ortholog Information

Human gene(s) in FlyBase

Other mammalian ortholog(s) used

D. melanogaster Gene Information (4)

Dmel\wry

Gene Snapshot

weary (wry) encodes a ligand for the receptor encoded by N. It is involved in the Notch signaling pathway and normal heart function. [Date last reviewed: 2019-09-12]

Molecular function (GO)

Cellular component (GO)

cell surface

Gene Groups / Pathways

NTCH-C
DSL

Comments on ortholog(s)

Low-scoring ortholog of human DNER; Dmel\wry shares 27% identity and 42% similarity with the human gene.

Orthologs and Alignments from DRSC

DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans

H. sapiens (Human)

Dmel\Delta

Gene Snapshot

Delta (Delta) encodes a single pass transmembrane EGF family protein and one of two ligands of the Notch signaling pathway. It regulates cell fate decisions and cell proliferation. Post transcriptional modification (such as by fucosylation, ubiquitination and proteolysis) of the product of Delta is key for its functions. [Date last reviewed: 2019-03-07]

Molecular function (GO)

Cellular component (GO)

Gene Groups / Pathways

NTCH-C
DSL

Comments on ortholog(s)

Moderate- to high-scoring ortholog of human DLL1 and DLL4; Dmel\Dl shares 39% identity and 51-53% similarity with the human genes.

Orthologs and Alignments from DRSC

DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans

H. sapiens (Human)

Dmel\Ser

Gene Snapshot

Contributions welcome

Molecular function (GO)

Cellular component (GO)

Gene Groups / Pathways

NTCH-C
DSL

Comments on ortholog(s)

Moderate-scoring ortholog of human JAG1 and JAG2; Dmel\Ser shares 33-35% identity and 46% similarity with the human genes.

Orthologs and Alignments from DRSC

DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans

H. sapiens (Human)

Dmel\N

Gene Snapshot

Contributions welcome

Molecular function (GO)

Cellular component (GO)

Gene Groups / Pathways

Comments on ortholog(s)

Moderate- to high-scoring ortholog of NOTCH1, NOTCH2, NOTCH3, NOTCH4. Dmel\N shares 43-44% identity and 56-57% similarity with NOTCH1, and NOTCH2; it is less closely related to NOTCH3 and NOTCH4.

Orthologs and Alignments from DRSC

DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans

H. sapiens (Human)

Other Genes Used: Viral, Bacterial, Synthetic (0)

Summary of Physical Interactions (63 groups)

wry

protein-protein

Interacting group

Assay

References

wry - N

inferred by author, confocal microscopy, bead aggregation assay

(Kim et al., 2010)

Delta

RNA-RNA

Interacting group

Assay

References

Delta - mir-1

immunohistochemistry, luminiscence technology

(Kwon et al., 2005)

protein-protein

Interacting group

Assay

References

Delta

bead aggregation assay, fluorescence microscopy, inferred by author, atomic force microscopy

(Parks et al., 2006, Ahimou et al., 2004)

Delta - kuz

protease assay, western blot, inferred by author

(Qi et al., 1999)

Delta - mib1

enzymatic study, anti tag coimmunoprecipitation, anti tag western blot

(Daskalaki et al., 2011, Lai et al., 2005)

Delta - N

bead aggregation assay, fluorescence microscopy, inferred by author, affinity technology, anti bait coimmunoprecipitation, cross-linking study, western blot, tag visualisation by alkaline phosphatase activity, tag visualisation, phenotype-based detection assay, enzyme linked immunosorbent assay, atomic force microscopy, pull down

(Pandey et al., 2019, Yamamoto et al., 2012, Acar et al., 2008, Pei and Baker, 2008, Xu et al., 2007, Parks et al., 2006, Ahimou et al., 2004, Bruckner et al., 2000, Wesley, 1999, Rebay et al., 1991, Fehon et al., 1990)

Delta - neur

anti tag coimmunoprecipitation, anti tag western blot, anti bait coimmunoprecipitation, pull down, western blot, enzymatic study

(Liu et al., 2012, Daskalaki et al., 2011, Fontana and Posakony, 2009, Commisso and Boulianne, 2007, Skwarek et al., 2007, Pitsouli and Delidakis, 2005)

Delta - O-fut1

anti tag coimmunoprecipitation, anti tag western blot

(Okajima et al., 2005)

Delta - sca

coimmunoprecipitation, western blot, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, affinity technology, fluorescence microscopy

(Petruccelli et al., 2018, Mok et al., 2005)

Ser

RNA-RNA

Interacting group

Assay

References

Ser - mir-8

fluorescence technology, necessary binding region, immunohistochemistry, luminiscence technology

(Vallejo et al., 2011)

protein-protein

Interacting group

Assay

References

Ser - cno

anti tag coimmunoprecipitation, western blot

(Pérez-Gómez et al., 2013)

Ser - mib1

anti tag coimmunoprecipitation, anti tag western blot

(Lai et al., 2005)

Ser - N

inferred by author, confocal microscopy, bead aggregation assay, affinity technology, tag visualisation, tag visualisation by alkaline phosphatase activity, fluorescence microscopy, anti bait coimmunoprecipitation, cross-linking study, western blot, anti tag coimmunoprecipitation, pull down

(Pandey et al., 2019, Fleming et al., 2013, Pérez-Gómez et al., 2013, Yamamoto et al., 2012, Kim et al., 2010, Xu et al., 2007, Pérez et al., 2005, Wesley, 1999, Rebay et al., 1991)

Ser - neur

anti bait coimmunoprecipitation, anti tag western blot, anti tag coimmunoprecipitation, western blot

(Liu et al., 2012, Glittenberg et al., 2006, Pitsouli and Delidakis, 2005)

protein-protein

Interacting group

Assay

References

electron microscopy, molecular weight, enzyme linked immunosorbent assay, two hybrid

(Kelly et al., 2010, Pei and Baker, 2008, Fortini and Artavanis-Tsakonas, 1994)

N - Abl

anti bait coimmunoprecipitation, western blot

(Koca et al., 2022)

N - Akap200

anti tag coimmunoprecipitation, western blot, anti tag western blot

(Bala Tannan et al., 2018)

N - arm

anti bait coimmunoprecipitation, western blot

(Koca et al., 2022, Hayward et al., 2005)

N - Caf1-55

anti tag coimmunoprecipitation, anti tag western blot

(Yu et al., 2013)

N - Caf1-105

anti tag coimmunoprecipitation, anti tag western blot

(Yu et al., 2013)

N - Caf1-180

anti tag coimmunoprecipitation, anti tag western blot

(Yu et al., 2013)

N - Cdk8

pull down, western blot

(Park et al., 2003)

N - CG10916

experimental knowledge based

(Guruharsha et al., 2011)

N - Chi

anti tag coimmunoprecipitation, western blot, pull down

(Sachan et al., 2015)

N - cno

anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, autoradiography, two hybrid

(Pérez-Gómez et al., 2013, Carmena et al., 2006)

N - crb

proximity ligation assay, fluorescence microscopy

(Nemetschke and Knust, 2016)

N - D

affinity technology, tag visualisation by alkaline phosphatase activity

(Pérez et al., 2005)

N - Dab

anti tag coimmunoprecipitation, western blot, pull down, autoradiography, anti bait coimmunoprecipitation

(Kannan et al., 2018, Le Gall et al., 2008, Le Gall and Giniger, 2004, Giniger, 1998)

N - Delta

N - dsh

two hybrid, anti bait coimmunoprecipitation, western blot, pull down, autoradiography

(Capilla et al., 2012, Muñoz-Descalzo et al., 2010, Hayward et al., 2005, Ramain et al., 2001, Axelrod et al., 1996)

N - dx

anti tag coimmunoprecipitation, western blot, anti tag western blot, two hybrid, cosedimentation in solution, predetermined participant, nuclear magnetic resonance

(Carter et al., 2023, Shimizu et al., 2014, Muñoz-Descalzo et al., 2010, Matsuno et al., 1995, Diederich et al., 1994)

N - Eogt

enzymatic study

(Sakaidani et al., 2011)

N - htk

anti bait coimmunoprecipitation, anti tag western blot, two hybrid, western blot, anti tag coimmunoprecipitation

(Singh et al., 2019)

N - Kap-α3

pull down, western blot, anti tag coimmunoprecipitation, two hybrid

(Sachan et al., 2013)

N - kuz

protease assay, western blot, inferred by author

(Pan and Rubin, 1997)

N - lilli

anti tag coimmunoprecipitation, anti tag western blot

(Liu et al., 2017)

N - mam

anti tag coimmunoprecipitation, peptide massfingerprinting, protein three hybrid, three hybrid

(Gahr et al., 2019, Nagel et al., 2017, Yuan et al., 2016, Maier et al., 2011, Veraksa et al., 2005, Petcherski and Kimble, 2000)

N - MED17

pull down, western blot

(Park et al., 2003)

N - MED21

pull down, western blot

(Park et al., 2003)

N - MED31

pull down, western blot

(Park et al., 2003)

N - msn

coimmunoprecipitation, western blot

(Mishra et al., 2015)

N - ND-30

anti tag coimmunoprecipitation, western blot

(Lee et al., 2013)

N - Nedd4

anti tag coimmunoprecipitation, western blot, pull down

(Sakata et al., 2004)

N - numb

two hybrid, pull down, autoradiography

(Guo et al., 1996)

N - O-fut1

anti tag coimmunoprecipitation, western blot, anti tag western blot

(Sasamura et al., 2007, Okajima et al., 2005)

N - Pink1

anti tag coimmunoprecipitation, western blot

(Lee et al., 2013)

N - Pngl

experimental knowledge based

(Guruharsha et al., 2011)

N - polo

experimental knowledge based

(Guruharsha et al., 2011)

N - pyd

anti tag coimmunoprecipitation, anti tag western blot

(Shimizu et al., 2017)

N - Rbfox1

anti bait coimmunoprecipitation, western blot

(Shukla et al., 2017)

N - sca

anti tag coimmunoprecipitation, western blot

(Petruccelli et al., 2018)

N - Ser

N - shg

anti bait coimmunoprecipitation, western blot

(Sasaki et al., 2007)

N - spdo

anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, anti tag western blot, pull down

(Upadhyay et al., 2013, O'Connor-Giles and Skeath, 2003)

N - Su(dx)

pull down, autoradiography, molecular weight estimation by staining, isothermal titration calorimetry, predetermined participant, western blot, nuclear magnetic resonance

(Yao et al., 2018, Jennings et al., 2007, Wilkin et al., 2004)

N - Su(H)

isothermal titration calorimetry, predetermined participant, anti bait coimmunoprecipitation, western blot, two hybrid, molecular sieving, molecular weight estimation by staining, pull down, autoradiography, anti tag coimmunoprecipitation, peptide massfingerprinting, protein three hybrid, three hybrid, anti tag western blot, cosedimentation, coimmunoprecipitation, electrophoretic mobility shift assay, electrophoretic mobility supershift assay, electron microscopy

N - Taf9

anti tag coimmunoprecipitation, anti tag western blot

(Xie et al., 2014)

N - Traf6

two hybrid, pull down, western blot, anti tag coimmunoprecipitation

(Mishra et al., 2014)

N - trio

anti bait coimmunoprecipitation, western blot

(Kannan et al., 2018, Le Gall et al., 2008)

N - uif

anti tag coimmunoprecipitation, anti tag western blot

(Loubéry et al., 2014)

N - Vps26

anti tag coimmunoprecipitation, anti tag western blot

(Li et al., 2018)

N - Vps35

anti tag coimmunoprecipitation, anti tag western blot

(Li et al., 2018)

N - wg

anti bait coimmunoprecipitation, cross-linking study, western blot

(Wesley, 1999)

N - wry

inferred by author, confocal microscopy, bead aggregation assay

(Kim et al., 2010)

RNA-protein

Interacting group

Assay

References

N - Sxl

nucleic acid uv cross-linking assay, autoradiography, anti bait coimmunoprecipitation, quantitative reverse transcription pcr

(Penn and Schedl, 2007)

N - TBPH

pull down, quantitative reverse transcription pcr

(Swain et al., 2016)

Alleles Reported to Model Human Disease (Disease Ontology) (40 alleles)

wry

Models Based on Experimental Evidence ( 3 )

Allele

Disease

Evidence

References

wry^f00122

model of dilated cardiomyopathy

CEA

(Kim et al., 2010)

wry^MB00103

model of dilated cardiomyopathy

CEA

(Kim et al., 2010)

wry^VDRC.cUa

model of dilated cardiomyopathy

CEA

(Kim et al., 2010)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Delta

Models Based on Experimental Evidence ( 2 )

Allele

Disease

Evidence

References

Delta^UAS.cDa

model of cancer

CEA with lola^GS88A8, psq^GS88A8

(Even et al., 2019, Vallejo et al., 2011, Bossuyt et al., 2009, Ferres-Marco et al., 2006)

CEA with ato^{ERD.UAS.Tag:MYC}

(Bossuyt et al., 2009)

CEA with bsk^DN.UAS

(Bossuyt et al., 2009)

CEA with ato^RNAi.UAS.J

(Bossuyt et al., 2009)

CEA with Not3^KK102144

(Vicente et al., 2018)

CEA with Not3^GD4068

(Vicente et al., 2018)

CEA with twin^KK108897

(Vicente et al., 2018)

CEA with Pop2^GD12804

(Vicente et al., 2018)

CEA with Rga^GL00386

(Vicente et al., 2018)

CEA with Not1^GD9640

(Vicente et al., 2018)

CEA

(Zhai et al., 2012)

CEA with ct^RNAi.cGa.UAS

(Zhai et al., 2012)

model of hematologic cancer

CEA with ct^RNAi.cGa.UAS, lola^GS88A8, psq^GS88A8

(Zhai et al., 2012)

Delta^DN.UAS

model of dilated cardiomyopathy

CEA

(Kim et al., 2010)

Modifiers Based on Experimental Evidence ( 9 )

Allele

Disease

Interaction

References

Delta^HMS01309

ameliorates brain cancer

modeled by Vps35^E42

(Li et al., 2018)

Delta^9P

ameliorates multiple endocrine neoplasia type 2B

modeled by Ret^MEN2B.GMR

(Read et al., 2005)

ameliorates multiple endocrine neoplasia type 2A

modeled by Ret^MEN2A.GMR

(Read et al., 2005)

Delta^RevF10

ameliorates cancer

modeled by Src64B^UAS.cCa

(Enomoto et al., 2021)

ameliorates amyotrophic lateral sclerosis

modeled by Hsap\TARDBP^UAS.cHa, Ser^RX82

(Zhan et al., 2013)

Delta^S049520

ameliorates multiple endocrine neoplasia type 2B

modeled by Ret^MEN2B.GMR

(Read et al., 2005)

ameliorates multiple endocrine neoplasia type 2A

modeled by Ret^MEN2A.GMR

(Read et al., 2005)

Delta^UAS.cDa

model of cancer

is exacerbated by mys^HMS00043

(Zhai et al., 2012)

is exacerbated by ItgaPS4^KK105806

(Zhai et al., 2012)

is exacerbated by ct^RNAi.cGa.UAS

(Zhai et al., 2012)

is exacerbated by Not3^KG10496

(De Keersmaecker et al., 2013)

is exacerbated by Not3^GD4068

(De Keersmaecker et al., 2013)

is exacerbated by Not3^KK102144

(De Keersmaecker et al., 2013)

Delta^JF02867

ameliorates carcinoma

modeled by Egfr^UAS.cBa, psq^KK111691

(Boukhatmi et al., 2020)

Delta⁰⁵¹⁵¹

exacerbates ataxia telangiectasia

modeled by tefu^RNAi.UAS

(Rimkus et al., 2008)

Delta^KK107312

exacerbates Alzheimer's disease

modeled by Psn^RNAi.UAS.3

(Kang et al., 2024)

Delta^DN.UAS

ameliorates brain cancer

modeled by Vps35^E42

(Li et al., 2018)

DOES NOT ameliorate cancer

modeled by Hipk^UAS.Tag:HA

(Blaquiere et al., 2018)

ameliorates cancer

modeled by Src64B^UAS.cCa

(Enomoto et al., 2021)

Ser

Models Based on Experimental Evidence ( 2 )

Allele

Disease

Evidence

References

Ser^DN.UAS

model of dilated cardiomyopathy

CEA

(Kim et al., 2010)

Ser^VDRC.cUa

model of dilated cardiomyopathy

CEA

(Kim et al., 2010)

Modifiers Based on Experimental Evidence ( 2 )

Allele

Disease

Interaction

References

Ser^RX82

ameliorates amyotrophic lateral sclerosis

modeled by Hsap\TARDBP^UAS.cHa, Delta^RevF10

(Zhan et al., 2013)

Ser¹

ameliorates Schimke immuno-osseous dysplasia

modeled by Marcal1^UAS.cBa

(Morimoto et al., 2016)

Models Based on Experimental Evidence ( 11 )

Allele

Disease

Evidence

References

N^DN.UAS

model of cancer

CEA with Ras85D^V12.cUa.UAS

(Lee et al., 2021)

CEA

(Lee et al., 2021, Tamamouna et al., 2021)

model of intestinal cancer

CEA

(Singh et al., 2016)

N^ICN.UAS

model of cancer

CEA

(Wang et al., 2021, Harsh and Eleftherianos, 2020)

CEA with Mef2^UAS.cUa

(Harsh and Eleftherianos, 2020)

model of carcinoma

CEA with Mef2^UAS.cUa

(Pallavi et al., 2012)

CEA with egr^UAS.cUa

(Pallavi et al., 2012)

model of brain cancer

CEA

(Wang et al., 2006)

N^UAS.cMa

model of adenoid cystic carcinoma

CEA with Hsap\MYB^ΔC.UAS, Xpd^{RNAi.UAS.012.1}, ft^{RNAi.UAS.012.1}, kug^{RNAi.UAS.012.1}

(Bangi et al., 2021)

CEA with Hsap\MYB^ΔC.UAS, Xpd^{RNAi.UAS.012.2}, ft^{RNAi.UAS.012.2}, kug^{RNAi.UAS.012.2}

(Bangi et al., 2021)

N^UAS.icd

model of central nervous system cancer

CEA

(Zacharioudaki et al., 2016)

N^RNAi.P.UAS

model of intestinal cancer

CEA

(Chen et al., 2021)

CEA with mys^GD15002

(Chen et al., 2021)

model of cancer

CEA with Ras85D^V12.UAS

(Tamamouna et al., 2021)

N^int.U.UAS

model of cervical cancer

CEA with Hsap\UBE3A^UAS.cRa, HPV18\E6^UAS.Tag:MYC

(Padash Barmchi et al., 2016)

model of adenocarcinoma

CEA

(Casas-Tintó et al., 2016)

CEA with wupA^f06492

(Casas-Tintó et al., 2016)

model of central nervous system cancer

CEA

(Magadi et al., 2020, Zacharioudaki et al., 2016)

model of carcinoma

CEA with l(2)gl^GD4047

(Jevitt et al., 2021)

N^{UAS.Tag:V5,Tag:polyHis}

model of brain cancer

CEA

(Ojha et al., 2022)

N^RNAi.UAS.cUa

model of intestinal cancer

CEA

(Ayyaz et al., 2015)

N^GD144

model of alcohol use disorder

CEA

(Petruccelli et al., 2018)

N^GD14477

model of intestinal cancer

CEA

(Banreti et al., 2022)

model of colorectal cancer

CEA

(Zipper et al., 2022)

N^HD_CFD01184

model of intestinal cancer

CEC with Spyo\Cas9^UAS.uM.-FRT

(Bahuguna et al., 2021)

CEC with Spyo\Cas9^UAS.P2

(Bahuguna et al., 2021)

Modifiers Based on Experimental Evidence ( 21 )

Allele

Disease

Interaction

References

N^DN.UAS

model of cancer

is ameliorated by Atg1^UAS.cSa

(Lee et al., 2021)

is ameliorated by wg^JF01257

(Lee et al., 2021)

ameliorates carcinoma

modeled by Vps25^N55

(Herz et al., 2006)

ameliorates intestinal cancer

modeled by yki^{S111A.S168A.S250A.UAS.Tag:V5}

(Pranoto et al., 2023)

N^ECN.UAS

ameliorates cancer

modeled by Src64B^UAS.cCa

(Enomoto et al., 2021)

N^{FLN.ΔCdc10.UAS}

ameliorates frontotemporal dementia and/or amyotrophic lateral sclerosis 1

modeled by Zzzz\poly-GR^{80.UAS.Tag:FLAG}

(Li et al., 2020)

N^ICN.UAS

model of cancer

is ameliorated by CycE^HMS00060

(Wang et al., 2021)

is ameliorated by Dref^JF02232

(Wang et al., 2021)

is ameliorated by RPA1^GL00350

(Wang et al., 2021)

is ameliorated by SMC5^HMC04343

(Wang et al., 2021)

is ameliorated by fzr^GD9960

(Wang et al., 2021)

is ameliorated by mei-41^GL00284

(Wang et al., 2021)

is ameliorated by mre11^HMC02995

(Wang et al., 2021)

is exacerbated by stg^UAS.Tag:HA

(Wang et al., 2021)

is ameliorated by stg^RNAi.UAS.cUa

(Wang et al., 2021)

exacerbates cancer

modeled by Src64B^UAS.cCa

(Enomoto et al., 2021)

modeled by Hipk^UAS.Tag:HA

(Blaquiere et al., 2018)

exacerbates carcinoma

modeled by scrib¹

(Brumby and Richardson, 2003)

N^UAS.icd

model of central nervous system cancer

is ameliorated by hth^C1

(Zacharioudaki et al., 2016)

is exacerbated by mira^HMS00347

(Zacharioudaki et al., 2016)

is ameliorated by svp¹

(Zacharioudaki et al., 2016)

is ameliorated by hth^B2

(Zacharioudaki et al., 2016)

N^RNAi.P.UAS

model of intestinal cancer

is exacerbated by Cat^HMS00990

(Chen et al., 2021)

is ameliorated by Cat^UAS.cUa

(Chen et al., 2021)

is exacerbated by Sod2^HMS00499

(Chen et al., 2021)

is exacerbated by cnc^HMS00650

(Chen et al., 2021)

is ameliorated by cnc^UAS.cSa

(Chen et al., 2021)

is ameliorated by Sod2^UAS.cMa

(Chen et al., 2021)

ameliorates carcinoma

modeled by Vps25^A3

(Vaccari and Bilder, 2005)

N^fa-swb

ameliorates Parkinson's disease 1

modeled by Hsap\SNCA^UAS.cJa

(Rousseaux et al., 2018)

N^int.U.UAS

exacerbates carcinoma

modeled by l(2)gl^GD4047

(Jevitt et al., 2021)

model of central nervous system cancer

is ameliorated by gcm^{UAS.ORF.GW.Tag:HA}

(Magadi et al., 2020)

is ameliorated by zfh1^UAS.cPa

(Magadi et al., 2020)

N^intra.GS.UAS

ameliorates cancer

modeled by Pvr^{λ.UASp.Tag:MYC}

(Wang et al., 2023)

N^l1N-ts1

ameliorates brain cancer

modeled by aurA⁸⁸³⁹

(Wang et al., 2006)

ameliorates frontotemporal dementia and/or amyotrophic lateral sclerosis 7

modeled by Hsap\CHMP2B^Intron5.UAS

(Wilson et al., 2020)

N^nd-1

ameliorates Schimke immuno-osseous dysplasia

modeled by Marcal1^UAS.cBa

(Morimoto et al., 2016)

N^nd-3

ameliorates Schimke immuno-osseous dysplasia

modeled by Marcal1^UAS.cBa

(Morimoto et al., 2016)

N^{UAS.Tag:V5,Tag:polyHis}

model of brain cancer

is ameliorated by ND-49^HM05059

(Ojha et al., 2022)

is ameliorated by Scer\NDI1^UAS.cBa

(Ojha et al., 2022)

ameliorates frontotemporal dementia and/or amyotrophic lateral sclerosis 1

modeled by Zzzz\poly-GR^{80.UAS.Tag:FLAG}

(Li et al., 2020)

modeled by Zzzz\poly-GA^{80.UAS.Tag:FLAG}

(Li et al., 2020)

modeled by Zzzz\poly-PR^{80.UAS.Tag:FLAG}

(Li et al., 2020)

N^JF01637

ameliorates carcinoma

modeled by l(2)gl^GD4047

(Chatterjee et al., 2023)

N^RNAi.UAS.cUa

model of intestinal cancer

is ameliorated by Smox^JF02320

(Ayyaz et al., 2015)

N^GD14477

model of intestinal cancer

is exacerbated by Pcmt^GD8637

(Banreti et al., 2022)

is exacerbated by Pcmt^RNAi.UAS

(Banreti et al., 2022)

ameliorates cancer

modeled by Src64B^UAS.cCa

(Enomoto et al., 2021)

model of colorectal cancer

is ameliorated by mir-277^UAS.cSa

(Zipper et al., 2022)

ameliorates brain cancer

modeled by Vps35^E42

(Li et al., 2018)

N^NICD.UASp

exacerbates carcinoma

modeled by l(2)gl^GD4047

(Chatterjee et al., 2023)

N^{sfGFP,Tag:FLAG}

ameliorates Adams-Oliver syndrome

modeled by Su(H)^T4

(Gagliani et al., 2022)

N^JF02959

ameliorates rhabdoid cancer

modeled by Snr1^HMS00363, BacA\p35^UAS.cHa

(Xie et al., 2017)

N^RNAi.lexAop

ameliorates carcinoma

modeled by Egfr^UAS.cBa, psq^KK111691

(Boukhatmi et al., 2020)

N^UAS.cGa

ameliorates autism spectrum disorder

modeled by Nrx-IV⁴³⁰⁴

(Grice et al., 2015)

Alleles Representing Disease-Implicated Variants

Genetic Tools, Stocks and Reagents

Sources of Stocks

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Bloomington Stock Center Disease Page

Related mammalian, viral, bacterial, or synthetic transgenes

Allele

Transgene

Publicly Available Stocks

Selected Drosophila transgenes

Allele

Transgene

Publicly Available Stocks

N^HD_CFD01184

P{HD_CFD01184}

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD01184}attP40/CyO-GFP

P{hsFLP}12, y¹ w^*; P{UAS-N.ECN}2; MKRS/TM2

N^ICN.UAS

P{UAS-N.ICN}

N^{FLN.ΔCdc10.UAS}

P{UAS-N.FLNDeltaCdc10}

N^{UAS.Tag:V5,Tag:polyHis}

P{UAS-N.V5}

N^{sfGFP,Tag:FLAG}

PBac{N-GFP.FLAG}

y¹ w^*; PBac{N-GFP.FLAG}VK00033/TM6C, Sb¹

w¹¹¹⁸; Dr¹ e¹/TM3, P{UAS-Delta.DN}TJ1, Sb¹

RNAi constructs available

Allele

Transgene

Publicly Available Stocks

N^{RNAi.13xlexAop.cZa}

P{13xlexAop-N.RNAi.Z}

N^RNAi.P.UAS

P{UAS-N.RNAi.M}

w^*; P{UAS-N.RNAi.P}9G

w¹¹¹⁸; P{GD14477}v27228/TM3

y¹ v¹; P{TRiP.JF02959}attP2

N^JF01637

P{TRiP.JF01637}

y¹ v¹; P{TRiP.JF01637}attP2

N^JF01043

P{TRiP.JF01043}

y¹ v¹; P{TRiP.JF01043}attP2

N^JF01053

P{TRiP.JF01053}

y¹ v¹; P{TRiP.JF01053}attP2

N^JF01356

P{TRiP.JF01356}

y¹ v¹; P{TRiP.JF01356}attP2

N^JF01693

P{TRiP.JF01693}

y¹ v¹; P{TRiP.JF01693}attP2

y¹ v¹; P{TRiP.HMS00001}attP2

N^HMS00009

P{TRiP.HMS00009}

y¹ v¹; P{TRiP.HMS00009}attP2

y¹ sc^* v¹ sev²¹; P{TRiP.GL00092}attP2

N^GLV21004

P{TRiP.GLV21004}

y¹ sc^* v¹ sev²¹; P{TRiP.GLV21004}attP2

P{UAS-Delta.RNAi.XK8}

w¹¹¹⁸; P{GD2642}v37287

y¹ v¹; P{TRiP.JF02867}attP2

Delta^HMS01309

P{TRiP.HMS01309}

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01309}attP2

y¹ sc^* v¹ sev²¹; P{TRiP.GL00520}attP40

w¹¹¹⁸; P{GD14453}v27172

y¹ v¹; P{TRiP.JF03140}attP2

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01179}attP2

wry^GD2636

P{GD2636}

w¹¹¹⁸; P{GD2636}v8021

y¹ v¹; P{TRiP.JF03393}attP2/TM3, Sb¹

y¹ v¹; P{TRiP.HMJ21124}attP40/CyO

Selected Drosophila classical alleles

Allele

Allele class

Mutagen

Publicly Available Stocks

N^ETX52

amorphic allele - genetic evidence

Delta2-3 transposase

N^55e11

loss of function allele

spontaneous

N^55e11 P{neoFRT}19A/FM7c

N^fa-g

loss of function allele

spontaneous

w^a N^fa-g; Rho1^E3.10/CyO

N^264-40

amorphic allele - genetic evidence

X ray

w^a N^264-40 rb¹/C(1)DX, y¹ w¹ f¹; Dp(1;2)72c21/+

N^FE1

loss of function allele

X ray

N^l1N-ts1

ethyl methanesulfonate

y¹ N^l1N-ts1 g² f¹/C(1)DX, y¹ w¹ f¹

N^S-317

loss of function allele

ethyl methanesulfonate

N^l1N-2

amorphic allele - genetic evidence

gamma ray

N^FX9

loss of function allele

X ray

N^FE2

loss of function allele

X ray

N^FX8

loss of function allele

X ray

N¹

loss of function allele

y¹ w^* N¹/FM7c, P{GAL4-twi.G}108.4, P{UAS-2xEGFP}AX

N^FX4

loss of function allele

X ray

N^eU10

loss of function allele

ethyl methanesulfonate

N^eAS7b

loss of function allele

ethyl methanesulfonate

N^60g11

amorphic allele - genetic evidence

X ray

N^FX2

loss of function allele

X ray

N^XL86

loss of function allele

ethyl methanesulfonate

N²

loss of function allele

N^FX5

loss of function allele

X ray

N^FX7

loss of function allele

X ray

N^Yi66

loss of function allele

ethyl methanesulfonate

N^264-47

loss of function allele

X ray

N^264-39

loss of function allele

X ray

w^ch2 N^264-39/FM4, Bar⁺

N^X81K1

loss of function allele

N^fa-swb

X ray

w^a N^fa-swb

N³

loss of function allele

N^3b22

loss of function allele

ethyl methanesulfonate

N^FX6

loss of function allele

X ray

N^XK11

amorphic allele - genetic evidence

N^nd-1

loss of function allele

spontaneous

N^nd-1 rb¹

N^M1

loss of function allele

ethyl methanesulfonate

N^FX3

loss of function allele

X ray

N^FX1

loss of function allele

X ray

N^X114

loss of function allele

ethyl methanesulfonate

N^66l2

amorphic allele - genetic evidence

N^nd-3

X ray

N^nd-3 rb¹/C(1)DX, y¹ f¹

Delta⁰⁵¹⁵¹

P-element activity

Delta^S049520

Delta2-3 transposase

Delta^ΔExon2

amorphic allele - molecular evidence

CRISPR/Cas9

Delta^BX44

amorphic allele - genetic evidence

X ray

Delta^FE27

amorphic allele - genetic evidence

ethyl methanesulfonate

Delta^9P

amorphic allele - genetic evidence

ethyl methanesulfonate

ru¹ hry¹ Diap1^th-1 st¹ cu¹ sr¹ Delta^9P e^s ca¹/TM3, Sb¹

Delta^BE30

amorphic allele - genetic evidence

ethyl methanesulfonate

Delta^B2

amorphic allele - genetic evidence

ethyl methanesulfonate

Delta^B2 e¹/TM6C, Sb¹

Delta³

loss of function allele

spontaneous

Delta³/In(3R)C, sprd¹ e¹

Delta^RevF10

loss of function allele

Delta^RevF10 e^* Ser^RX82 P{neoFRT}82B/TM6B, Tb¹

Delta^M1

loss of function allele

X ray

Delta^BE32

amorphic allele - genetic evidence

ethyl methanesulfonate

Delta^M

loss of function allele

spontaneous

Delta^X

amorphic allele - genetic evidence

Delta^X/In(3L)P, In(3R)P

Delta^vi3

loss of function allele

ethyl methanesulfonate

Delta^vi1

loss of function allele

ethyl methanesulfonate

Delta^CE21

amorphic allele - genetic evidence

ethyl methanesulfonate

Delta^BX38

amorphic allele - genetic evidence

X ray

Delta^CE23

amorphic allele - genetic evidence

ethyl methanesulfonate

Delta^BX39

amorphic allele - genetic evidence

X ray

Delta^KX1

amorphic allele - genetic evidence

X ray

Delta^M3

loss of function allele

ethyl methanesulfonate

Delta^M2

loss of function allele

spontaneous

Delta^EP3816.A

loss of function allele

Delta2-3 transposase

Ser¹

spontaneous

Antp^D43 / TM3, y⁺ kni^ri-1 vvl^sep Ubx^bx-34e e^s Ser¹

Ser^mf553

loss of function allele

minos activity

Ser^CS94

amorphic allele - genetic evidence

Ser^RX82

loss of function allele

X ray

Delta^RevF10 e^* Ser^RX82 P{neoFRT}82B/TM6B, Tb¹

Ser^RX107

loss of function allele

X ray

Ser^RX106

amorphic allele - genetic evidence

X ray

mwh¹ red¹ e¹ Ser^RX106/TM6B, Tb¹

Ser^rev2-11

loss of function allele

X ray

wry^f00122

piggyBac activity

wry^MB00103

y¹ w^67c23; Mi{ET1}wry^MB00103

References (7)

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