FB2024_04 , released June 25, 2024
Human Disease Model Report: ovarian dysgenesis
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General Information
Name
ovarian dysgenesis
FlyBase ID
FBhh0001016
Disease Ontology Term
Parent Disease
OMIM
Overview

This report describes general characteristics of the group of diseases classified as ovarian dysgenesis (ODG). A comprehensive list of ODG subtypes, as defined by OMIM, can be found by following the link in the "OMIM phenotypic series" section, below. A subset of these are listed in the table below, with links to more detailed reports for subtypes that have been investigated using fly models.

Disease Summary Information
Parent Disease Summary: ovarian dysgenesis
OMIM report
Symptoms and phenotype

Hypergonadotropic ovarian failure is a heterogeneous disorder that, in the most severe forms, is a result of ovarian dysgenesis. Ovarian dysgenesis accounts for about half the cases of primary amenorrhea (pubmed:12836721). [from MIM:233300; 2019.05.06]

(OMIM, 2013-)
Genetics

46,XX ovarian dysgenesis is etiologically heterogeneous. [from MIM:233300; 2019.05.06] See the phenotypic series for multiple types of ODG, linked to different causative genes.

(OMIM, 2013-)
Cellular phenotype and pathology
Molecular information
External links
    Disease synonyms
    Ortholog Information
    Human gene(s) in FlyBase
      Other mammalian ortholog(s) used
        D. melanogaster Gene Information (0)
        Other Genes Used: Viral, Bacterial, Synthetic (0)
          Summary of Physical Interactions (0 groups)
          Alleles Reported to Model Human Disease (Disease Ontology) (0 alleles)
          Alleles Representing Disease-Implicated Variants
          Genetic Tools, Stocks and Reagents
          Sources of Stocks
          Contact lab of origin for a reagent not available from a public stock center.
          Bloomington Stock Center Disease Page
          Related mammalian, viral, bacterial, or synthetic transgenes
          Allele
          Transgene
          Publicly Available Stocks
          Selected Drosophila transgenes
          Allele
          Transgene
          Publicly Available Stocks
          RNAi constructs available
          Allele
          Transgene
          Publicly Available Stocks
          Selected Drosophila classical alleles
          Allele
          Allele class
          Mutagen
          Publicly Available Stocks
          References (2)