Human Disease Model Report: acute myeloid leukemia models, RAS-Scrib-complex-related

General Information

Name

acute myeloid leukemia models, RAS-Scrib-complex-related

FlyBase ID

FBhh0001042

Disease Ontology Term

myeloid leukemia

Parent Disease

OMIM

Overview

In flies, hemocyte-specific expression of an activated form of RAS (Dmel\Ras85D^V12) in combination with knockdown of either scrib or l(2)gl results in dramatic increases in hemocyte number (in the range of 100-fold). The animals typically die during the larval or pupal stage. Phenotypes reminiscent of cachexia are observed. Responses to infectious agents have been assessed.

The constitutively active Ras85D mutation, Ras85D^V12, is analogous to oncogenic mutations found in human RAS proteins. Variant(s) implicated in human disease tested (as analogous mutation in fly gene): G12V in the fly Ras85D gene (corresponds to G12V in the human KRAS and HRAS genes).

The Scribble polarity complex plays a key role in determining cell polarity and cell proliferation in epithelial cells. Classical amorphic and hypomorphic mutations, RNAi-targeting constructs, and alleles caused by insertional mutagenesis have been generated for both scrib and l(2)gl.

Drosophila cancer models using Ras85D^V12 and genes encoding components of the Scribble complex have been developed using epithelial systems. See 'cancer, epithelial, RAS-LLGL-related' (FBhh0000588) and 'cancer, epithelial, RAS-SCRIB-related' (FBhh0000585).

[updated May 2019 by FlyBase; FBrf0222196]

Disease Summary Information

Disease Summary: acute myeloid leukemia models, RAS-Scrib-complex-related

OMIM report

Human gene(s) implicated

Symptoms and phenotype

Genetics

Cellular phenotype and pathology

Molecular information

External links

COSMIC gene: SCRIB
COSMIC gene: LLGL1
COSMIC gene: LLGL2
COSMIC gene: NRAS
COSMIC gene: HRAS
COSMIC gene: KRAS
KEGG Disease Pathways: Acute myeloid leukemia

Disease synonyms

Search term: hyperplastic phenotype(s)

Related Diseases

Related human health report(s)

acute myeloid leukemia

cancer, epithelial, RAS-LLGL-related

cancer, epithelial, RAS-SCRIB-related

Ortholog Information

Human gene(s) in FlyBase

Other mammalian ortholog(s) used

D. melanogaster Gene Information (3)

Dmel\Ras85D

Gene Snapshot

Ras oncogene at 85D (Ras85D) encodes a protein that acts downstream of several cell signals, most notably from Receptor Tyrosine Kinases, to regulate tissue growth and development. When abnormally activated it can direct developmental defects and tissue hyperplasia, mimicking aspects of human disease including Rasopathies and cancer, respectively. [Date last reviewed: 2019-03-14]

Molecular function (GO)

Cellular component (GO)

Gene Groups / Pathways

Comments on ortholog(s)

High-scoring ortholog of human genes KRAS, HRAS, and NRAS (many to many; multiple paralogs and orthologs in both species). Dmel\Ras85D shares 78-86% identity and 86-92% similarity with KRAS, HRAS, and NRAS; for these three human genes, Ras85D is the highest-scoring ortholog in Drosophila.

Orthologs and Alignments from DRSC

DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans

H. sapiens (Human)

Dmel\scrib

Gene Snapshot

scribble (scrib) encodes a scaffolding protein that is part of the conserved machinery regulating apicobasal polarity. It acts with the products of dlg1 and l(2)gl to distinguish the basolateral domain of epithelial cells and neuroblasts, via reciprocally antagonistic interactions with the aPKC/par-6 complex that impacts vesicle trafficking. The product of scrib also organizes synaptic architecture and is implicated in learning and memory. [Date last reviewed: 2019-03-14]

Molecular function (GO)

Cellular component (GO)

Gene Groups / Pathways

SCRIBC

Comments on ortholog(s)

Ortholog of human SCRIB and LRRC1 (1 Drosophila to 2 human); Dmel\scrib shares 33% identity and 45% similarity with the human SCRIB gene. The human LRRC1 gene encodes a much smaller protein, corresponding to the amino end of SCRIB and Dmel\scrib; it shares 57% identity and 73% similarity with Dmel\scrib within that extent.

Orthologs and Alignments from DRSC

DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans

H. sapiens (Human)

Dmel\l(2)gl

Gene Snapshot

lethal (2) giant larvae (l(2)gl) encodes a tumor suppressor protein that regulates cell polarity and asymmetric cell division. It acts on the basolateral side of epithelial cells, antagonizing the activity of apical complex proteins encoded by baz, par-6 and aPKC. [Date last reviewed: 2019-09-26]

Molecular function (GO)

Cellular component (GO)

Gene Groups / Pathways

Comments on ortholog(s)

Moderate- to high-scoring ortholog of human LLGL1 and LLGL2 (1 Drosophila to 2 human). Dmel\l(2)gl shares 34-36% identity and 51-54% similarity with the human genes.

Orthologs and Alignments from DRSC

DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans

H. sapiens (Human)

Other Genes Used: Viral, Bacterial, Synthetic (0)

Summary of Physical Interactions (58 groups)

Ras85D

protein-protein

Interacting group

Assay

References

Ras85D - alt

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

Ras85D - Arc1

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

Ras85D - CG31550

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

Ras85D - cindr

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

Ras85D - cno

two hybrid, anti tag coimmunoprecipitation, autoradiography

(Boettner and Van Aelst, 2007, Carmena et al., 2006)

Ras85D - Droj2

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

Ras85D - eIF3i

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

Ras85D - glo

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

Ras85D - Gyc76C

anti tag coimmunoprecipitation, anti tag western blot

(Iwashita et al., 2020)

Ras85D - lark

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

Ras85D - mod(mdg4)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

Ras85D - Nf1

gtpase assay, autoradiography

(Walker et al., 2006)

Ras85D - Nop60B

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

Ras85D - Pi3K92E

two hybrid, pull down, western blot

(Orme et al., 2006)

Ras85D - pico

two hybrid

(Lyulcheva et al., 2008)

Ras85D - Pyk

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

Ras85D - Raf

pull down, two hybrid, anti tag coimmunoprecipitation, anti tag western blot

(Yang and Terman, 2012, Ding et al., 2010, Mishra et al., 2005)

Ras85D - rau

pull down, anti tag western blot

(Sieglitz et al., 2013)

Ras85D - Rgl

two hybrid

(Mirey et al., 2003)

Ras85D - RpL6

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

Ras85D - RpL15

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

Ras85D - RpL21

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

Ras85D - RpL23A

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

Ras85D - RpL24

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

Ras85D - RpS2

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

Ras85D - RpS27

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

Ras85D - spri

anti tag coimmunoprecipitation, anti tag western blot

(Jekely et al., 2005)

Ras85D - Sumo

anti tag coimmunoprecipitation, Identification by mass spectrometry, pull down, covalent binding, western blot

(Nie et al., 2009)

scrib

protein-protein

Interacting group

Assay

References

scrib

anti tag coimmunoprecipitation, anti tag western blot

(Gui et al., 2016)

scrib - α-Cat

anti tag coimmunoprecipitation, anti tag western blot

(Huang et al., 2023)

scrib - bark

proximity ligation assay, fluorescence microscopy

(Sharifkhodaei et al., 2019)

scrib - dlg1

colocalization, fluorescence microscopy, inferred by author, anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation, proximity-dependent biotin identification, proximity ligation assay

(Sharp et al., 2021, Ventura et al., 2020, Nakajima et al., 2019, Sharifkhodaei et al., 2019, Rui et al., 2017, Mathew et al., 2002)

scrib - Gli

proximity ligation assay, fluorescence microscopy

(Sharifkhodaei et al., 2019)

scrib - gukh

anti bait coimmunoprecipitation, western blot, isothermal titration calorimetry, predetermined participant, x-ray crystallography

(Caria et al., 2018, Mathew et al., 2002)

scrib - Mad

anti tag coimmunoprecipitation, anti tag western blot

(Gui et al., 2016)

scrib - Nrx-1

anti tag coimmunoprecipitation, western blot, pull down

(Rui et al., 2017)

scrib - Pak

anti tag coimmunoprecipitation, western blot

(Bahri et al., 2010)

scrib - Pak3

anti tag coimmunoprecipitation, western blot

(Cervantes-Sandoval et al., 2016, Bahri et al., 2010)

scrib - Rab5

anti tag coimmunoprecipitation, anti tag western blot

(Gui et al., 2016)

scrib - Rac1

anti tag coimmunoprecipitation, western blot

(Cervantes-Sandoval et al., 2016)

scrib - tkv

anti tag coimmunoprecipitation, anti tag western blot

(Gui et al., 2016)

scrib - Traf4

pull down, autoradiography

(Mathew et al., 2011)

scrib - tsr

anti tag coimmunoprecipitation, western blot

(Cervantes-Sandoval et al., 2016)

scrib - Vang

pull down, autoradiography, two hybrid, anti tag coimmunoprecipitation, anti tag western blot

(Humphries et al., 2023, Courbard et al., 2009)

l(2)gl

protein-protein

Interacting group

Assay

References

l(2)gl

anti tag coimmunoprecipitation, anti tag western blot

(Betschinger et al., 2005)

l(2)gl - aPKC

anti tag coimmunoprecipitation, peptide massfingerprinting, anti bait coimmunoprecipitation, western blot, experimental knowledge based, proximity ligation assay, fluorescence microscopy

(Portela et al., 2024, Calero-Cuenca et al., 2016, Goh et al., 2013, Guruharsha et al., 2011, Tian and Deng, 2008, Wirtz-Peitz et al., 2008, Betschinger et al., 2003)

l(2)gl - ball

anti tag coimmunoprecipitation, western blot

(Link et al., 2019)

l(2)gl - ctp

two hybrid

(Hu et al., 2017.6.13)

l(2)gl - dsh

anti tag coimmunoprecipitation, western blot

(Kaplan and Tolwinski, 2010)

l(2)gl - Git

proximity ligation assay, fluorescence microscopy

(Portela et al., 2024)

l(2)gl - mahj

anti tag coimmunoprecipitation, anti tag western blot

(Tamori et al., 2010)

l(2)gl - mts

anti tag coimmunoprecipitation, western blot

(Ogawa et al., 2009)

l(2)gl - Pak

anti tag coimmunoprecipitation, western blot

(Bahri et al., 2010)

l(2)gl - par-1

anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation

(Tian and Deng, 2008)

l(2)gl - par-6

pull down, western blot, anti tag coimmunoprecipitation, peptide massfingerprinting, anti bait coimmunoprecipitation, experimental knowledge based, autoradiography, anti tag western blot

(Neumüller et al., 2012, Guruharsha et al., 2011, Wirtz-Peitz et al., 2008, Hutterer et al., 2004, Betschinger et al., 2003)

l(2)gl - Vap33

proximity ligation assay, fluorescence microscopy, pull down, Identification by mass spectrometry, anti tag coimmunoprecipitation, anti tag western blot

(Portela et al., 2024, Portela et al., 2018)

l(2)gl - Vha44

anti tag coimmunoprecipitation, anti tag western blot

(Portela et al., 2018)

l(2)gl - zip

anti tag coimmunoprecipitation, anti tag western blot

(Betschinger et al., 2005)

Alleles Reported to Model Human Disease (Disease Ontology) (45 alleles)

Ras85D

Models Based on Experimental Evidence ( 16 )

Allele

Disease

Evidence

References

Ras85D^HMS01294

model of Noonan syndrome 3

CEA

(Cattaneo et al., 2020)

Ras85D^G12V.UAS

model of cancer

CEA with RhoGEF2^RE.UAS

(Khoo et al., 2013)

CEA with Rok^CAT.UAS

(Khoo et al., 2013)

CEA with sqh^{E20E21.UAS.cCa}

(Khoo et al., 2013)

Ras85D^G13Q.UAS

model of cancer

CEA with Pten^HMS00044, Rbf^HMS03004

(Parkhitko et al., 2021)

Ras85D^N17.UAS

model of Noonan syndrome 3

CEA

(Cattaneo et al., 2020)

Ras85D^Q13.UAS

model of cancer

CEA

(Tamamouna et al., 2021)

Ras85D^V12.GMR

model of cancer

CEA

(Okada et al., 2023)

Ras85D^V12.S35.UAS

model of cardiomyopathy

CEA

(Yu et al., 2013)

model of carcinoma

CEC

(Karim and Rubin, 1998)

Ras85D^V12.UAS

model of carcinoma

CEA

(Martínez-Abarca Millán and Martín-Bermudo, 2023, Ito and Igaki, 2021, Kong et al., 2021, Rackley et al., 2021, Soler Beatty et al., 2021, Wei et al., 2021, Wu et al., 2021, Murcia et al., 2019, Zoranovic et al., 2018, Igaki et al., 2006)

CEA with dlg1^GD4689

(Santabárbara-Ruiz and Léopold, 2021)

CEA with l(2)gl⁴

(Ding et al., 2022, Singh et al., 2022, Ito and Igaki, 2021, Wu et al., 2021, Mishra-Gorur et al., 2019, Zhang et al., 2019, Srivastava et al., 2007, Igaki et al., 2006)

CEA with Lkb1^4A4-2

(Rackley et al., 2021)

CEA with scrib¹

(Kong et al., 2021, Mishra-Gorur et al., 2019, Srivastava et al., 2007, Igaki et al., 2006, Uhlirova and Bohmann, 2006)

CEA with dlg1¹⁴

(Ito and Igaki, 2021, Igaki et al., 2006)

CEA with shg^k03401

(Igaki et al., 2006)

CEA with scrib⁶⁷³

(Amcheslavsky et al., 2018)

CEA with msn³²⁰⁸

(Kong et al., 2021)

CEA with sna^UAS.cAa

(Wu et al., 2021)

CEA with scrib^KK101128

(Murcia et al., 2019)

CEC

(Karim and Rubin, 1998)

CEA with scrib^HMJ21977

(Snigdha et al., 2021)

model of cancer

CEA with fmt¹

(Ma et al., 2017)

CEA with PpV^Δ1

(Ma et al., 2017)

CEA with l(2)gl⁴

(Guo et al., 2020, Ma et al., 2017, Ma et al., 2013, Pagliarini and Xu, 2003)

CEA with PpV^GD7532

(Ma et al., 2017)

CEA

(Khalili et al., 2023, Martínez-Abarca Millán et al., 2023, Enomoto et al., 2021, Santabárbara-Ruiz and Léopold, 2021, Tamamouna et al., 2021, Ma et al., 2020, Jung et al., 2019, Rives-Quinto et al., 2017, Chabu and Xu, 2014, Hirabayashi et al., 2013, Ma et al., 2013)

CEA with scrib⁶⁷³

(Katheder et al., 2017)

CEA with scrib¹

(Cong et al., 2021, Hodgson et al., 2021, Katheder et al., 2017, Figueroa-Clarevega and Bilder, 2015, Külshammer et al., 2015, Willoughby et al., 2013, Wu et al., 2010, Pagliarini and Xu, 2003)

CEA with dlg1^GD4689

(Katheder et al., 2017, Muzzopappa et al., 2017, Figueroa-Clarevega and Bilder, 2015, Willecke et al., 2011)

CEA with Src64B^UAS.cCa

(Enomoto et al., 2021)

CEA with scrib^j7B3

(Pagliarini and Xu, 2003)

CEA with dlg1¹⁴

(Pagliarini and Xu, 2003)

CEA with baz⁴

(Pagliarini and Xu, 2003)

CEA with sdt^XN

(Pagliarini and Xu, 2003)

CEA with Cdc42¹

(Pagliarini and Xu, 2003)

CEA with dor^C107

(Chi et al., 2010)

CEA with dor⁸

(Chi et al., 2010)

CEA with dor^D185

(Chi et al., 2010)

CEA with car^RNAi.UAS

(Chi et al., 2010)

CEA with Vps16A^RNAi.UAS.WIZ

(Chi et al., 2010)

CEA with upd1^UAS.cUa

(Wu et al., 2010)

CEA with upd2^UAS.cUa

(Wu et al., 2010)

CEA with upd1^UAS.cUa, upd2^UAS.cUa, upd3^UAS.cUa

(Wu et al., 2010)

CEA with l(2)gl^unspecified

(Wu et al., 2010)

CEA with pnut^GD1512

(Gerlach et al., 2018)

CEA with Hsap\S100A4^wt.UAS

(Ismail et al., 2017)

CEA with scrib^RNAi.UAS.cUa

(Hodgson et al., 2021)

CEA with Csk^Q156Stop

(Hirabayashi et al., 2013)

CEA with scrib^KK101128

(Muzzopappa et al., 2017)

CEA with mud^JF02911

(Muzzopappa et al., 2017)

CEA with mud^HMS01458

(Muzzopappa et al., 2017)

CEA with N^RNAi.P.UAS

(Tamamouna et al., 2021)

CEA with emei^GD3587

(Ma et al., 2020)

CEA with Rox8^GD11645

(Guo et al., 2020)

CEA with BacA\p35^UAS.cHa

(Khalili et al., 2023)

CEA with dlg1^RNAi.UAS.cUa

(Bakopoulos et al., 2023)

model of intestinal cancer

CEA

(Cabrera et al., 2023, Nászai et al., 2021)

model of colorectal cancer

CEA

(Bangi et al., 2012)

model of leukemia

CEA

(Arefin et al., 2017)

CEA with l(2)gl^KK100777

(Arefin et al., 2017)

CEA with scrib^KK101128

(Arefin et al., 2017)

model of benign neoplasm

CEA with Alg9^c02021

(de Vreede et al., 2018)

DOES NOT model cancer

CEA with Hsap\S100A4^Δ2.UAS

(Ismail et al., 2017)

model of heart disease

CEA

(Karekar et al., 2021)

model of prostate cancer

CEA

(Rambur et al., 2020)

model of kidney cancer

CEA

(Zeng et al., 2010)

model of hypertrophic cardiomyopathy

CEA

(Petersen et al., 2022)

Ras85D^V12.ey

model of carcinoma

CEC

(Karim and Rubin, 1998)

Ras85D^V12.cUa.UAS

model of cervical cancer

CEA

(Padash Barmchi et al., 2016)

CEA with Hsap\UBE3A^UAS.cRa, HPV18\E6^UAS.Tag:MYC

(Padash Barmchi et al., 2016)

CEA with Hsap\UBE3A^UAS.cRa, HPV18\E6^{V158A.UAS.Tag:MYC}

(Padash Barmchi et al., 2016)

model of cancer

CEA with l(2)gl⁴

(Fangninou et al., 2023, Liu et al., 2022, Yang et al., 2022)

CEA with Ptp61F^Δ

(Liu et al., 2022)

CEA with Syx7³¹¹⁹

(Liu et al., 2022)

CEA with Rabex-5³⁶⁷²

(Liu et al., 2022)

CEA with Vps36²⁵⁸⁶

(Liu et al., 2022)

CEA with TSG101^P26

(Liu et al., 2022)

CEA with N^DN.UAS

(Lee et al., 2021)

CEA with dlg1^RNAi.UAS.cUa

(Lodge et al., 2021)

CEA

(Yang et al., 2022, Dong et al., 2021, Yeom et al., 2021, Dunn et al., 2018, Vicente et al., 2018)

CEA with scrib¹

(Yang et al., 2022, Khezri et al., 2021)

CEA with baz⁴

(Yang et al., 2022)

CEA with fmt¹

(Yang et al., 2022)

CEA with dlg1^GD4689

(Yang et al., 2022)

CEA with Ptip³⁸⁰⁴

(Dong et al., 2021)

model of colorectal cancer

CEA

(Zipper et al., 2022)

CEA with Pten^sgRNA.UAS

(Zipper et al., 2022)

CEA with Med^sgRNA.UAS

(Zipper et al., 2022)

CEA with cic^sgRNA.UAS

(Zipper et al., 2022)

CEA with Apc2^sgRNA.UAS

(Zipper et al., 2022)

CEA with Apc^sgRNA.UAS

(Zipper et al., 2022)

CEA with p53^sgRNA.UAS

(Zipper et al., 2022)

CEA with p53^VDRC.cUa, Pten^GD13500, Apc^VDRC.cUa, Med^VDRC.cUa

(Bangi et al., 2016)

CEA with p53^VDRC.cUa, Pten^GD13500, Apc^VDRC.cUa

(Bangi et al., 2016)

CEA with p53^VDRC.cUa, Apc^VDRC.cUa, Med^VDRC.cUa

(Bangi et al., 2016)

CEA with Pten^GD13500, Apc^VDRC.cUa, Med^VDRC.cUa

(Bangi et al., 2016)

model of cardiomyopathy

CEA

(Yu et al., 2013)

model of adenocarcinoma

CEA with l(2)gl^GD4047

(Casas-Tintó et al., 2016)

CEA with l(2)gl^GD4047, wupA^JF02172

(Casas-Tintó et al., 2016)

model of carcinoma

CEA with Scer\GAL4^nub.PU

(Hogan et al., 2009)

CEA with l(2)gl⁴

(Sun et al., 2019)

CEA with dlg1^HMS00172

(Toggweiler et al., 2016)

model of intestinal cancer

CEA with Apc^Q8

(Campbell et al., 2019)

CEA

(Kim et al., 2022, Singh et al., 2016)

CEA with Apc^GD1333, p53^GD4483

(Quintero and Bangi, 2023)

CEA with Apc^GD1333, Pten^RNAi.UAS.cUa, p53^GD4483

(Quintero and Bangi, 2023)

CEA with Apc^GD1333, Med^GD1483, p53^GD4483

(Quintero and Bangi, 2023)

model of high grade glioma

CEA with Pten^{RNAi.Exel.UAS}

(Gangwani et al., 2020)

CEA

(Liu et al., 2021)

model of brain cancer

CEA with dlg1^GD4689

(Manzanero-Ortiz et al., 2021)

CEA with l(2)gl^KK100777

(Manzanero-Ortiz et al., 2021)

CEA with wts^KK101055

(Manzanero-Ortiz et al., 2021)

CEA with scrib⁶⁷³

(Manzanero-Ortiz et al., 2021)

Ras85D^V152G.UASp

model of Noonan syndrome 3

CEA

(Cattaneo et al., 2020)

Ras85D^{G12V.UAS.Tag:FLAG,Tag:polyHis}

model of cancer

CEA

(Washington et al., 2020)

Ras85D^{Y4F.G12V.UAS.Tag:FLAG,Tag:polyHis}

model of cancer

CEA

(Washington et al., 2020)

Ras85D^V12.QUAS.cHa

model of cancer

CEA with scrib¹

(Hodgson et al., 2021)

Ras85D^V12.QUAS.cLa

model of cancer

CEA with scrib^{QUAS.HMS01490}

(Bakopoulos et al., 2023, Lodge et al., 2021)

Ras85D^{G12D.UAS.p53sh}

model of pancreatic ductal adenocarcinoma

CEA with CycE^{UAS.Tag:HA.Medsh}, Med^{RNAi.UAS.CycE-HA}, p53^{RNAi.UAS.RasG12D}

(Sekiya et al., 2023)

Modifiers Based on Experimental Evidence ( 17 )

Allele

Disease

Interaction

References

Ras85D^ΔC40B

ameliorates multiple endocrine neoplasia type 2B

modeled by Ret^MEN2B.GMR

(Read et al., 2005)

Ras85D⁰⁶⁶⁷⁷

ameliorates autosomal dominant cerebellar ataxia

modeled by Hsap\ATXN1^82Q.UAS

(Park et al., 2013)

ameliorates multiple endocrine neoplasia type 2B

modeled by Ret^MEN2B.GMR

(Read et al., 2005)

ameliorates multiple endocrine neoplasia type 2A

modeled by Ret^MEN2A.GMR

(Read et al., 2005)

ameliorates alveolar rhabdomyosarcoma

modeled by Hsap\FOXO1::Hsap\PAX7^UAS.cGa

(Galindo et al., 2006)

Ras85D^N17.UAS

ameliorates brain glioma

modeled by btl::Egfr^λ.UAS, Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}

(Read et al., 2009)

Ras85D^Q13.UAS

model of cancer

is ameliorated by Cat^UAS.cAa

(Tamamouna et al., 2021)

is ameliorated by Sod1^UAS.cAa

(Tamamouna et al., 2021)

is ameliorated by btl^DN.UAS

(Tamamouna et al., 2021)

Ras85D^V12.GMR

model of cancer

is ameliorated by InR^K1409A.UAS

(Okada et al., 2023)

is ameliorated by NetB^Δ

(Okada et al., 2023)

is ameliorated by NetB^KK103672

(Okada et al., 2023)

is ameliorated by NetB^VSH330183

(Okada et al., 2023)

is ameliorated by InR^GL00139

(Okada et al., 2023)

is ameliorated by InR^JF01183

(Okada et al., 2023)

is ameliorated by InR^JF01482

(Okada et al., 2023)

is ameliorated by unc-5^HMS01099

(Okada et al., 2023)

is ameliorated by unc-5^KK102074

(Okada et al., 2023)

is ameliorated by unc-5^MI04273

(Okada et al., 2023)

Ras85D^V12.UAS

model of carcinoma

is exacerbated by mys^RNAi.UAS.cUa

(Martínez-Abarca Millán and Martín-Bermudo, 2023)

is exacerbated by dap^HMS01610

(Ito and Igaki, 2021)

is exacerbated by dap^HMS05362

(Ito and Igaki, 2021)

is ameliorated by pnt^P1.UAS

(Ito and Igaki, 2021)

is exacerbated by hep^Act.UAS

(Uhlirova and Bohmann, 2006)

is exacerbated by egr^UAS.cIa

(Igaki et al., 2006)

is exacerbated by ZnT86D^KK101698

(Wei et al., 2021)

is exacerbated by msn¹⁷²

(Kong et al., 2021)

is exacerbated by msn³²⁰⁸

(Kong et al., 2021)

is exacerbated by l(2)gl⁴

(Wu et al., 2021)

is exacerbated by sna^UAS.cAa

(Wu et al., 2021)

is ameliorated by rl^GD4697

(Murcia et al., 2019)

is ameliorated by Raf^DN.UAS

(Zoranovic et al., 2018)

is exacerbated by Tsp29Fb^GD1018

(Zoranovic et al., 2018)

is ameliorated by Tsp29Fb^UAS.Tag:HA

(Zoranovic et al., 2018)

is ameliorated by Hsap\CDKN1A^UAS.cHa

(Karim and Rubin, 1998)

is ameliorated by Raf^XS-2541

(Karim and Rubin, 1998)

is exacerbated by rl^Sem

(Karim and Rubin, 1998)

is exacerbated by Egfrap^ΔSH2

(Soler Beatty et al., 2021)

is exacerbated by Egfrap^HMJ23378

(Soler Beatty et al., 2021)

is exacerbated by Egfrap^LS

(Soler Beatty et al., 2021)

is exacerbated by Egfrap^L

(Soler Beatty et al., 2021)

is exacerbated by PVRAP^HMJ23233

(Soler Beatty et al., 2021)

is ameliorated by HAdV-C\E4orf4^UAS.cPa

(Rosen et al., 2019)

is ameliorated by HAdV-C\E4orf4^UAS.cPb

(Rosen et al., 2019)

model of cancer

is ameliorated by Sec15^KK101708

(Chabu and Xu, 2014)

is ameliorated by Sec6^GD11616

(Chabu and Xu, 2014)

is ameliorated by Sec8^KK101531

(Chabu and Xu, 2014)

is ameliorated by Sec15¹

(Chabu and Xu, 2014)

is ameliorated by Sec15^GD12109

(Chabu and Xu, 2014)

is ameliorated by Src64B^GD12263

(Ma et al., 2013)

is ameliorated by chinmo¹

(Enomoto et al., 2021)

is exacerbated by PVRAP¹

(Martínez-Abarca Millán et al., 2023)

is exacerbated by PVRAP^HMJ23233

(Martínez-Abarca Millán et al., 2023)

is exacerbated by by^33c

(Martínez-Abarca Millán et al., 2023)

is exacerbated by by^VSH330366

(Martínez-Abarca Millán et al., 2023)

is exacerbated by Csk^Q156Stop

(Hirabayashi et al., 2013)

is exacerbated by emei¹

(Ma et al., 2020)

is exacerbated by emei²

(Ma et al., 2020)

is exacerbated by emei³

(Ma et al., 2020)

is ameliorated by Arc1^esm18

(Khalili et al., 2023)

is exacerbated by Nek2^UAS.GFP

(Das et al., 2013)

model of intestinal cancer

is ameliorated by shg^HMS00693

(Cabrera et al., 2023)

is ameliorated by Cortactin^HMS00658

(Cabrera et al., 2023)

is ameliorated by Cortactin^KK108594

(Cabrera et al., 2023)

is ameliorated by shg^JF02769

(Cabrera et al., 2023)

exacerbates alveolar rhabdomyosarcoma

modeled by Hsap\FOXO1::Hsap\PAX7^UAS.cGa

(Galindo et al., 2006)

exacerbates gastrointestinal system cancer

modeled by Apc2^g10, Apc^Q8

(Wang et al., 2013)

model of colorectal cancer

is ameliorated by Timp^UAS.cPa

(Bangi et al., 2012)

is ameliorated by bsk^DN.UAS

(Bangi et al., 2012)

is ameliorated by bsk^HMS00777

(Bangi et al., 2012)

is exacerbated by hep^Act.UAS

(Bangi et al., 2012)

is exacerbated by imd^UAS.cGa

(Bangi et al., 2012)

is ameliorated by Jra^NIG.2275R

(Bangi et al., 2012)

ameliorates cancer

modeled by dlg1^A40.2

(Parisi et al., 2014)

exacerbates carcinoma

modeled by scrib¹

(Brumby and Richardson, 2003)

modeled by arm^UAS.Exel

(Zhang et al., 2019)

model of prostate cancer

is ameliorated by Egfr^GD1654

(Rambur et al., 2020)

is ameliorated by Pi3K92E^HMC05152

(Rambur et al., 2020)

is ameliorated by mTor^GL00156

(Rambur et al., 2020)

is ameliorated by rl^HMS00173

(Rambur et al., 2020)

is ameliorated by spi^HMS01120

(Rambur et al., 2020)

exacerbates intestinal cancer

modeled by Rab11^KK108297

(Nie et al., 2019)

exacerbates cancer

modeled by Hipk^UAS.Tag:HA

(Blaquiere et al., 2018)

model of kidney cancer

is ameliorated by Pka-C1^B3

(Zeng et al., 2010)

is ameliorated by mTor^ΔP

(Zeng et al., 2010)

exacerbates Alzheimer's disease 1

modeled by Hsap\APP^{Aβ42.UAS.cUa}

(Cheng et al., 2021)

Ras85D^V12.ey

model of carcinoma

is ameliorated by Raf^XS-2541

(Karim and Rubin, 1998)

Ras85D^e1B

ameliorates alveolar rhabdomyosarcoma

modeled by Hsap\FOXO1::Hsap\PAX7^UAS.cGa

(Galindo et al., 2006)

exacerbates viral infectious disease

modeled by EBV\BZLF1^GMR.PA

(Adamson and Lajeunesse, 2012)

exacerbates infectious mononucleosis

modeled by EBV\BZLF1^GMR.PA

(Adamson and Lajeunesse, 2012)

exacerbates Epstein-Barr virus hepatitis

modeled by EBV\BZLF1^GMR.PA

(Adamson and Lajeunesse, 2012)

ameliorates gastrointestinal system cancer

modeled by Apc2^g10, Apc^Q8

(Wang et al., 2013)

exacerbates tuberous sclerosis

modeled by Tsc1^UAS.cTa, gig^UAS.cTa

(Tapon et al., 2001)

ameliorates cancer

modeled by Alk^UAS.cLa

(Wolfstetter et al., 2020)

Ras85D^e2F

ameliorates alveolar rhabdomyosarcoma

modeled by Hsap\FOXO1::Hsap\PAX7^UAS.cGa

(Galindo et al., 2006)

Ras85D^unspecified

ameliorates neurofibromatosis

modeled by Nf1^E2

(Walker et al., 2006)

Ras85D^V12.cUa.UAS

model of cancer

is exacerbated by ex^e1

(Liu et al., 2022)

is exacerbated by Ptp61F^Δ

(Liu et al., 2022)

is exacerbated by Not3^KK102144

(Vicente et al., 2018)

is exacerbated by M6^W186stop

(Dunn et al., 2018)

is ameliorated by Ptip³⁸⁰⁴

(Dong et al., 2021)

is exacerbated by p53^UAS.cUa

(Dong et al., 2021)

is ameliorated by Ilp8^MI00727

(Yeom et al., 2021)

model of intestinal cancer

is ameliorated by Cortactin^HMS00658

(Kim et al., 2022)

model of high grade glioma

is ameliorated by Dcp-1^RNAi.UAS.cUa

(Liu et al., 2021)

is exacerbated by Nmnat^UAS.PC

(Liu et al., 2021)

is ameliorated by Nmnat^RNAi.UAS.cUa

(Liu et al., 2021)

Ras85D^GD12553

ameliorates colorectal cancer

modeled by Src42A^CA.UAS

(Cordero et al., 2014)

modeled by Src64B^UAS.cCa

(Cordero et al., 2014)

ameliorates neurofibromatosis

modeled by Nf1^JF01866

(Georganta et al., 2021)

Ras85D^KK108029

ameliorates colorectal cancer

modeled by Src42A^CA.UAS

(Cordero et al., 2014)

modeled by Src64B^UAS.cCa

(Cordero et al., 2014)

ameliorates intestinal cancer

modeled by Egfr^UAS.cBa

(Nászai et al., 2021)

Ras85D^JF02478

ameliorates colorectal cancer

modeled by SH3PX1^HMJ21552

(Zhang et al., 2019)

Ras85D^{G12V.UAS.Tag:FLAG,Tag:polyHis}

model of cancer

is exacerbated by Egfr^2.UAS

(Washington et al., 2020)

is ameliorated by Rabex-5^{DPYT.UAS.Tag:MYC}

(Washington et al., 2020)

is exacerbated by hop^JF01267

(Washington et al., 2020)

Ras85D^{Y4F.G12V.UAS.Tag:FLAG,Tag:polyHis}

model of cancer

is exacerbated by Egfr^2.UAS

(Washington et al., 2020)

is ameliorated by Rabex-5^{DPYT.UAS.Tag:MYC}

(Washington et al., 2020)

Ras85D^DN.UAS.cUa

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^{Aβ42.UAS.cUa}

(Cheng et al., 2021)

scrib

Models Based on Experimental Evidence ( 10 )

Allele

Disease

Evidence

References

scrib^KK101128

model of cancer

CEA

(Tamori et al., 2016)

CEA with Stat92E^{ΔNΔC.UASp.Tag:HA}, RhoGEF2^HMS01118

(Tamori et al., 2016)

CEA with Ras85D^V12.UAS

(Muzzopappa et al., 2017)

model of leukemia

CEA with Ras85D^V12.UAS

(Arefin et al., 2017)

model of carcinoma

CEA with Ras85D^V12.UAS

(Murcia et al., 2019)

scrib^j7B3

model of cancer

CEA with Hsap\SCRIB^UAS.EGFP

(Dow et al., 2003)

CEA with Ras85D^V12.UAS

(Pagliarini and Xu, 2003)

scrib^GD11663

model of carcinoma

CEA

(Wu et al., 2021)

model of cancer

CEA

(Yang et al., 2022)

scrib⁶⁷³

model of carcinoma

CEA with scrib¹

(de Vreede et al., 2022)

CEA

(de Vreede et al., 2022, Brumby and Richardson, 2003, Bilder et al., 2000)

CEA with Ras85D^V12.UAS

(Amcheslavsky et al., 2018)

model of brain cancer

CEA with Ras85D^V12.cUa.UAS

(Manzanero-Ortiz et al., 2021)

model of cancer

CEA with Egfr^2.A887T.UAS

(Sheng and Du, 2020)

scrib^GD11666

model of cancer

CEA

(Ding et al., 2021)

model of carcinoma

CEA

(Ding et al., 2022, Sun et al., 2019, Zhang et al., 2019)

scrib¹

model of carcinoma

CEA

(Zheng et al., 2023, Kong et al., 2022, Kong et al., 2021, Parvy et al., 2019, Katsukawa et al., 2018, O'Keefe et al., 2015, Igaki et al., 2009, Uhlirova et al., 2005, Brumby and Richardson, 2003, Bilder et al., 2000)

CEA with scrib⁶⁷³

(de Vreede et al., 2022)

CEA with Ras85D^V12.UAS

(Kong et al., 2021, Mishra-Gorur et al., 2019, Srivastava et al., 2007, Igaki et al., 2006, Uhlirova and Bohmann, 2006)

CEA with Raf^UAS.F179

(Wei et al., 2021, Uhlirova et al., 2005)

CEA with egr¹

(Igaki et al., 2009)

CEA with Rab5^S43N.UAS

(Igaki et al., 2009)

model of cancer

CEA with Ras85D^V12.UAS

(Cong et al., 2021, Hodgson et al., 2021, Külshammer et al., 2015, Külshammer and Uhlirova, 2013, Willoughby et al., 2013, Wu et al., 2010, Pagliarini and Xu, 2003)

CEA with cno^R2

(Rives-Quinto et al., 2017)

CEA

(Sanaki et al., 2020, Bunker et al., 2015, Ohsawa et al., 2011)

CEA with rl^R80S.UAS

(Kushnir et al., 2020)

CEA with rl^{D334N.UAS.cKa}

(Kushnir et al., 2020)

CEA with rl^{R80S.D334N.UAS}

(Kushnir et al., 2020)

CEA with Ras85D^V12.QUAS.cHa

(Hodgson et al., 2021)

CEA with Ras85D^V12.cUa.UAS

(Yang et al., 2022, Khezri et al., 2021)

CEA with Raf^UAS.F179

(Yang et al., 2022)

model of benign neoplasm

CEA

(de Vreede et al., 2018)

model of kidney cancer

CEA

(Zeng et al., 2010)

scrib^HMS01490

model of cancer

CEA

(Bunker et al., 2015)

model of carcinoma

CEA

(Yadav and Srikrishna, 2019)

scrib^HMJ21977

model of carcinoma

CEA with yki^{S111A.S168A.S250A.UAS.Tag:V5}

(Snigdha et al., 2021)

CEA with Ras85D^V12.UAS

(Snigdha et al., 2021)

CEA

(Snigdha et al., 2021)

scrib^RNAi.UAS.cUa

model of carcinoma

CEA

(Song et al., 2023, Xu et al., 2022)

model of cancer

CEA with Ras85D^V12.UAS

(Hodgson et al., 2021)

scrib^{QUAS.HMS01490}

model of cancer

CEA with Ras85D^V12.QUAS.cLa

(Bakopoulos et al., 2023, Lodge et al., 2021)

Modifiers Based on Experimental Evidence ( 11 )

Allele

Disease

Interaction

References

scrib^KK101128

model of cancer

is exacerbated by Stat92E^{ΔNΔC.UASp.Tag:HA}

(Tamori et al., 2016)

scrib^j7B3

ameliorates viral infectious disease

modeled by EBV\BRLF1^GMR.PA

(Adamson and Lajeunesse, 2012)

ameliorates infectious mononucleosis

modeled by EBV\BRLF1^GMR.PA

(Adamson and Lajeunesse, 2012)

ameliorates Epstein-Barr virus hepatitis

modeled by EBV\BRLF1^GMR.PA

(Adamson and Lajeunesse, 2012)

scrib^GD11663

model of carcinoma

is ameliorated by CtBP^HMS00677

(Wu et al., 2021)

is ameliorated by CtBP^JF01291

(Wu et al., 2021)

is ameliorated by puc^UAS.cMa

(Wu et al., 2021)

model of cancer

is ameliorated by Ire1^UAS.Tag:V5

(Yang et al., 2022)

is ameliorated by Xbp1^UAS.s.Tag:V5

(Yang et al., 2022)

scrib⁶⁷³

exacerbates brain cancer

modeled by Ras85D^V12.cUa.UAS, dlg1^GD4689

(Manzanero-Ortiz et al., 2021)

modeled by Ras85D^V12.cUa.UAS, l(2)gl^KK100777

(Manzanero-Ortiz et al., 2021)

modeled by Ras85D^V12.cUa.UAS, wts^KK101055

(Manzanero-Ortiz et al., 2021)

scrib^GD11666

model of cancer

is exacerbated by hpo^RNAi.UAS.cUa

(Ding et al., 2021)

is exacerbated by wts^RNAi.UAS.cUa

(Ding et al., 2021)

is ameliorated by yki^RNAi.UAS.cUa

(Ding et al., 2021)

model of carcinoma

is ameliorated by lic^GD7546

(Sun et al., 2019)

is ameliorated by lic^JF01433

(Sun et al., 2019)

is ameliorated by pan^JF02306

(Zhang et al., 2019)

is ameliorated by wg^GD5007

(Zhang et al., 2019)

is exacerbated by Toll-7^{C993Y.UAS.Tag:FLAG}

(Ding et al., 2022)

is ameliorated by Toll-7^GD14417

(Ding et al., 2022)

is ameliorated by Toll-7^HM05230

(Ding et al., 2022)

scrib¹

model of carcinoma

is exacerbated by α-Spec^HMC04371

(Kong et al., 2022)

is exacerbated by Rho1^72F

(Kong et al., 2022)

is exacerbated by Rok^GD1522

(Kong et al., 2022)

is exacerbated by Toll-6^GD14438

(Kong et al., 2022)

is exacerbated by Toll-6^GD35

(Kong et al., 2022)

is exacerbated by kst^GLC01654

(Kong et al., 2022)

is exacerbated by sqh^GL00663

(Kong et al., 2022)

is exacerbated by zip^GD1566

(Kong et al., 2022)

is exacerbated by BacA\p35^UAS.cHa

(Zheng et al., 2023, Brumby and Richardson, 2003)

is ameliorated by Dad^UAS.cTa

(Brumby and Richardson, 2003)

is ameliorated by Egfr^DN.UAS

(Brumby and Richardson, 2003)

is exacerbated by N^ICN.UAS

(Brumby and Richardson, 2003)

is exacerbated by Ras85D^V12.UAS

(Brumby and Richardson, 2003)

is exacerbated by bsk^K53R.UAS

(Uhlirova et al., 2005, Brumby and Richardson, 2003)

is ameliorated by pan^ΔN.UAS

(Brumby and Richardson, 2003)

is ameliorated by Wwox^KK108459

(O'Keefe et al., 2015)

is exacerbated by Dif^LA00958

(Katsukawa et al., 2018)

is ameliorated by Spn88Ea^GD12724

(Katsukawa et al., 2018)

is ameliorated by Spn88Ea^HMS01371

(Katsukawa et al., 2018)

is ameliorated by Spn88Ea^c01214

(Katsukawa et al., 2018)

is ameliorated by Spn88Ea^eld5

(Katsukawa et al., 2018)

is exacerbated by Tl^10b.UAS

(Katsukawa et al., 2018)

is exacerbated by dl^UAS.cHa

(Katsukawa et al., 2018)

is ameliorated by hep^Act.UAS

(Uhlirova et al., 2005)

is ameliorated by kay^RNAi.UAS

(Uhlirova and Bohmann, 2006)

is ameliorated by puc^UAS.cMa

(Uhlirova and Bohmann, 2006)

is exacerbated by Def^SK3

(Parvy et al., 2019)

is exacerbated by egr³

(Parvy et al., 2019)

is exacerbated by bsk^DN.UAS.cUa

(Kong et al., 2021)

is ameliorated by msn^UAS.cSa

(Kong et al., 2021)

is ameliorated by Diap1^UAS.cHa

(Zheng et al., 2023)

is ameliorated by Dronc^DN.UAS.cUa

(Zheng et al., 2023)

is ameliorated by Ire1^GD3071

(Zheng et al., 2023)

is ameliorated by Ire1^f02170

(Zheng et al., 2023)

is ameliorated by Xbp1^GD4745

(Zheng et al., 2023)

is ameliorated by Xbp1^UAS.s.Tag:V5

(Zheng et al., 2023)

is exacerbated by bsk^DN.UAS

(Zheng et al., 2023)

is ameliorated by HAdV-C\E4orf4^UAS.cPa

(Rosen et al., 2019)

is ameliorated by HAdV-C\E4orf4^UAS.cPb

(Rosen et al., 2019)

model of cancer

is ameliorated by hep^r75

(Bunker et al., 2015)

is ameliorated by yki^B5

(Bunker et al., 2015)

is ameliorated by egr¹

(Ohsawa et al., 2011)

is ameliorated by Ilp2¹

(Sanaki et al., 2020)

is exacerbated by Ilp2^UAS.cBa

(Sanaki et al., 2020)

is ameliorated by Ilp5³

(Sanaki et al., 2020)

is ameliorated by InR^K1409A.UAS

(Sanaki et al., 2020)

is exacerbated by InR^UAS.Exel

(Sanaki et al., 2020)

is exacerbated by chico¹

(Sanaki et al., 2020)

is exacerbated by chico^KK107581

(Sanaki et al., 2020)

scrib^HMS01490

model of cancer

is ameliorated by dome^ΔCYT.UAS

(Bunker et al., 2015)

is ameliorated by Socs36E^UASp.cCa

(Bunker et al., 2015)

model of carcinoma

is exacerbated by park^JF01200

(Yadav and Srikrishna, 2019)

is ameliorated by park^{UAS.Tag:FLAG,Tag:Mito(hCOX4I1)}

(Yadav and Srikrishna, 2019)

scrib^HMJ21977

model of carcinoma

is ameliorated by wgn^GLC01716

(Snigdha et al., 2021)

scrib^UASp.cRa

exacerbates tauopathy

modeled by Hsap\MAPT^UAS.cWa

(Feuillette et al., 2020)

scrib^RNAi.UAS.cUa

model of carcinoma

is exacerbated by apt^GD1367

(Song et al., 2023)

is ameliorated by apt^UAS.cEa

(Song et al., 2023)

is ameliorated by Gadd45^KK104250

(Xu et al., 2022)

is ameliorated by Glyat^TH00482

(Xu et al., 2022)

is ameliorated by Glyat^c02982

(Xu et al., 2022)

is ameliorated by Gadd45^HMS01436

(Xu et al., 2022)

scrib^UAS.GFP

ameliorates autism spectrum disorder

modeled by Nrx-1²⁷³

(Rui et al., 2017)

l(2)gl

Models Based on Experimental Evidence ( 7 )

Allele

Disease

Evidence

References

l(2)gl¹

model of brain cancer

CEA

(Betschinger et al., 2006)

CEA with l(2)gl⁴

(Betschinger et al., 2006)

l(2)gl⁴

model of cancer

CEA with Ras85D^V12.cUa.UAS

(Fangninou et al., 2023, Liu et al., 2022, Yang et al., 2022)

CEA with Ras85D^V12.UAS

(Guo et al., 2020, Grifoni et al., 2015, Pagliarini and Xu, 2003)

CEA

(Janic et al., 2010, Woodhouse et al., 2003)

model of carcinoma

CEA

(Singh et al., 2022, Sollazzo et al., 2022, Rusu et al., 2021, Biehler et al., 2020, Tamori et al., 2010, Bilder et al., 2000)

CEA with yki^{UAS.cOa.Tag:V5}

(Enzo et al., 2015)

CEA with yki^UAS.cHa

(Singh et al., 2022)

CEA with Ras85D^V12.UAS

(Ding et al., 2022, Singh et al., 2022, Ito and Igaki, 2021, Wu et al., 2021, Mishra-Gorur et al., 2019, Zhang et al., 2019, Srivastava et al., 2007, Igaki et al., 2006)

CEA with Ras85D^V12.cUa.UAS

(Sun et al., 2019)

model of brain cancer

CEA

(Beaucher et al., 2007, Woodhouse et al., 2003)

CEA with l(2)gl¹

(Betschinger et al., 2006)

model of kidney cancer

CEA

(Zeng et al., 2010)

model of neuroblastoma

CEA

(Gateff and Schneiderman, 1974)

l(2)gl^4w3

model of carcinoma

CEA

(Bilder et al., 2000)

l(2)gl^HMS01522

model of carcinoma

CEA with Myc^UAS.Tag:HA

(Sollazzo et al., 2022)

CEA

(Singh et al., 2022)

l(2)gl^GD4047

model of cancer

CEA with RpL27A¹

(Grifoni et al., 2015)

CEA

(Tamori et al., 2016)

model of adenocarcinoma

CEA with Ras85D^V12.cUa.UAS

(Casas-Tintó et al., 2016)

CEA with wupA^f06492, Ras85D^V12.cUa.UAS

(Casas-Tintó et al., 2016)

model of carcinoma

CEA

(Chatterjee et al., 2023, Jevitt et al., 2021)

CEA with N^int.U.UAS

(Jevitt et al., 2021)

l(2)gl^KK100777

model of leukemia

CEA with Ras85D^V12.UAS

(Arefin et al., 2017)

model of brain cancer

CEA with Ras85D^V12.cUa.UAS

(Manzanero-Ortiz et al., 2021)

l(2)gl^HMS01905

model of cancer

CEA

(Chatterjee et al., 2022)

Modifiers Based on Experimental Evidence ( 4 )

Allele

Disease

Interaction

References

l(2)gl⁴

model of carcinoma

is exacerbated by Myc^UAS.Tag:HA

(Sollazzo et al., 2022)

is exacerbated by Hsf^UAS.EGFP

(Singh et al., 2022)

is ameliorated by Hsp83^NIG.1242R

(Singh et al., 2022)

is exacerbated by BacA\p35^UAS.cHa

(Rusu et al., 2021)

is exacerbated by CG7379^GD12222

(Rusu et al., 2021)

is ameliorated by mahj^UASp.cTa

(Tamori et al., 2010)

is exacerbated by Girdin²

(Biehler et al., 2020)

exacerbates carcinoma

modeled by Ras85D^V12.UAS

(Wu et al., 2021)

l(2)gl^ts3

ameliorates primary autosomal recessive microcephaly 16

modeled by Ankle2^A

(Link et al., 2019)

l(2)gl^GD4047

model of cancer

is exacerbated by Stat92E^{ΔNΔC.UASp.Tag:HA}

(Tamori et al., 2016)

is ameliorated by Stat92E^KK100519

(Tamori et al., 2016)

model of carcinoma

is exacerbated by N^int.U.UAS

(Jevitt et al., 2021)

is ameliorated by N^JF01637

(Chatterjee et al., 2023)

is exacerbated by N^NICD.UASp

(Chatterjee et al., 2023)

is ameliorated by Stat92E^KK100519

(Chatterjee et al., 2023)

is exacerbated by esg^EY10592

(Chatterjee et al., 2023)

is exacerbated by upd1^UAS.cZa

(Chatterjee et al., 2023)

l(2)gl^HMS01905

model of cancer

is exacerbated by Keap1^EY02632

(Chatterjee et al., 2022)

is ameliorated by Keap1^HMS02180

(Chatterjee et al., 2022)

is ameliorated by cnc^JF02006

(Chatterjee et al., 2022)

is exacerbated by cnc^UAS.cSa

(Chatterjee et al., 2022)

Alleles Representing Disease-Implicated Variants

Genetic Tools, Stocks and Reagents

Sources of Stocks

Contact lab of origin for a reagent not available from a public stock center.

Bloomington Stock Center Disease Page

Related mammalian, viral, bacterial, or synthetic transgenes

Allele

Transgene

Publicly Available Stocks

Selected Drosophila transgenes

Allele

Transgene

Publicly Available Stocks

Ras85D^V152G.UASp

P{UASp-Ras85D.V152G}

Ras85D^{G12V.UAS.Tag:FLAG,Tag:polyHis}

P{UAS-FH-Ras85D.G12V}

Ras85D^{Y4F.G12V.UAS.Tag:FLAG,Tag:polyHis}

P{UAS-FH-Ras85D.Y4F.G12V}

Ras85D^V12.QUAS.cHa

P{QUAS-Ras85D.V12.H}

Ras85D^V12.QUAS.cLa

PBac{QUAS-Ras85D.V12.L}

Ras85D^DN.UAS.cUa

P{UAS-Ras85D.DN.U}

Ras85D^{G12D.UAS.p53sh}

P{UAS-Ras85D(G12D).UAS-p53(shRNA)}

Ras85D^V12.UAS

P{UAS-Ras85D.V12}

w¹¹¹⁸; P{UAS-Ras85D.V12}TL1

Ras85D^N17.UAS

P{UAS-Ras85D.N17}

P{UAS-Ras85D.N17}TL1, w¹¹¹⁸

P{UAS-Ras85D.V12.S35}

w^*; P{UASp-scrib.R}B10

RNAi constructs available

Allele

Transgene

Publicly Available Stocks

w¹¹¹⁸; P{GD4047}v51247

l(2)gl^JF01073

P{TRiP.JF01073}

y¹ v¹; P{TRiP.JF01073}attP2

l(2)gl^JF01553

P{TRiP.JF01553}

y¹ v¹; P{TRiP.JF01553}attP2

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01522}attP2

l(2)gl^GL00645

P{TRiP.GL00645}

y¹ sc^* v¹ sev²¹; P{TRiP.GL00645}attP40

l(2)gl^HMS01905

P{TRiP.HMS01905}

y¹ v¹; P{TRiP.HMS01905}attP40

w¹¹¹⁸; P{GD12553}v28129

y¹ v¹; P{TRiP.JF02478}attP2

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01294}attP2

Ras85D^GL00336

P{TRiP.GL00336}

y¹ sc^* v¹ sev²¹; P{TRiP.GL00336}attP2/TM3, Sb¹

scrib^RNAi.UAS.cUa

P{UAS-scrib.RNAi.U}

scrib^{QUAS.HMS01490}

PBac{QUAS-HMS01490}

scrib^{RNAi.13xlexAop.cZa}

P{13xlexAop-scrib.RNAi.Z}

scrib^GD11666

P{GD11666}

w¹¹¹⁸ P{GD11666}v27430

y¹ v¹; P{TRiP.JF03229}attP2

scrib^HMS01490

P{TRiP.HMS01490}

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01490}attP2

y¹ sc^* v¹ sev²¹; P{TRiP.GL00638}attP40

scrib^HMS01993

P{TRiP.HMS01993}

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01993}attP40/CyO

y¹ v¹; P{TRiP.HMJ21977}attP40/CyO

scrib^RNAi.UAS

P{UAS-scrib.RNAi}

w^*; P{UAS-scrib.RNAi}7L

Selected Drosophila classical alleles

Allele

Allele class

Mutagen

Publicly Available Stocks

l(2)gl²⁷⁵

loss of function allele

spontaneous

l(2)gl⁴

amorphic allele - genetic evidence

spontaneous

y¹ w^67c23; l(2)gl⁴/CyO, y⁺

l(2)gl^4w3

w^*; l(2)gl^4w3 P{neoFRT}40A P{FRT(w^hs)}G13/CyO

l(2)gl¹

spontaneous

l(2)gl^ts3

ethyl methanesulfonate

y¹ w^*; l(2)gl^ts3 cn¹ speck¹/CyO, y⁺

l(2)gl^GX7w-

amorphic allele - molecular evidence

ends-out gene targeting

Ras85D⁰⁶⁶⁷⁷

P-element activity

P{PZ}Ras85D⁰⁶⁶⁷⁷ ry⁵⁰⁶/TM3, ry^RK Sb¹ Ser¹

Ras85D^e2F

sev¹⁴; Ras85D^e2F/TM3, Sb¹

Ras85D^e1B

ethyl methanesulfonate

sev¹⁴; Ras85D^e1B/TM3, Sb¹

Ras85D^unspecified

Ras85D^ΔC40B

loss of function allele

Ras85D^x7b

loss of function allele

P-element activity

Ras85D^Δ17b

amorphic allele - genetic evidence

scrib^j7B3

P-element activity

y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{neoFRT}82B P{lacW}scrib^j7B3/TM6B, P{Car20y}TPN1, Tb¹

scrib^ird15

loss of function allele

ethyl methanesulfonate

scrib¹

loss of function allele

ethyl methanesulfonate

scrib⁶⁷³

loss of function allele

ethyl methanesulfonate

Dp(1;Y)Bar^S; scrib⁶⁷³ e¹/TM3, Ser¹

References (5)

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