The Drosophila microRNA mir-980 was identified in a screen using a set of fly microRNA sponge constructs expressed pan-neuronally and assessed for effects on intermediate term olfactory aversive memory. Suppression of mir-980 results in enhanced memory formation (without altering odor and shock avoidance). Pan-neuronal overexpression of mir-980 results in pupal lethality; overexpression restricted to the mushroom body neurons results in impairment of memory formation.
The 5' seed sequence of Dmel\mir-980 is homologous to that of human MIR22.
Generating knockdowns effected by RNAi, predicted target genes of mir-980 were assessed using the intermediate term olfactory aversive memory assay. Dmel\Rbfox1, which has three predicted mir-980-binding sites in its 3' UTR, exhibits significant memory impairment in this assay. See the human disease model report 'neurodevelopmental disorders, susceptibility to (postulated), RBFOX-related' (FBhh0001100).
[updated Jul. 2019 by FlyBase; FBrf0222196]
Expression of human MIR22 is reduced in attention deficit hyperactivity disorder (ADHD); it is genetically associated with panic disorder and anxiety in humans (FBrf0231056 and references cited therein).
5' seed sequence homologous to that of human MIR22 (FBrf0242402).
