In a genomic study of variants associated with obesity in humans, rare variants associated with the gene SDK1 were identified. SDK1 encodes an adhesion molecule that contains multiple immunoglobulin-like domains and fibronectin type III domains. There is a single orthologous gene in Drosophila, sdk, for which multiple genetic reagents have been generated, including loss-of-function mutations, RNAi-targeting constructs, alleles caused by insertional mutagenesis, and over-expression constructs. Dmel\sdk is also orthologous to the human gene SDK2.
The human SDK1 gene has not been introduced into flies.
Animals homozygous for loss-of-function mutations of Dmel\sdk exhibit defects in adult eye development attributed to abnormal cell adhesion in the developing eye. Ubiquitous knockdown of sdk, effected by RNAi, results in a significant increase in triacylglyceride (TAG) level, measured as the ratio of TAG to protein.
[updated Dec. 2021 by FlyBase; FBrf0222196]
Obesity is an abnormal accumulation of body fat, usually 20% or more over an individual's ideal body weight. Obesity is associated with increased risk of illness, disability, and death. (http://medical-dictionary.thefreedictionary.com/obesity).
The development of obesity is recognized as having both genetic and environmental components (https://www.sciencelearn.org.nz/resources/203-obesity-genetic-or-environmental).
SDK1 encodes an adhesion molecule that contains multiple immunoglobulin-like domains and fibronectin type III domains. [Gene Cards, SDK1; 2021.12.14]
Many to one: 2 human genes to 1 Drosophila gene.
High-scoring ortholog of human SDK1 and SDK2.
