In an effort to identify genes critical to human heart development that are also expressed in other tissues, a screen for genes with cardiac-specific cis-regulatory elements was conducted in human. Identified candidate genes were assessed using orthologous genes in animal models, including Drosophila. The human ribosomal protein gene RPS24 was identified in this screen; RPS24 is also implicated in Diamond-Blackfan anemia 3 (MIM:610629).
A UAS construct of the human Hsap\RPS24 gene has been introduced into flies, but has not been characterized; a stock is available.
The orthologous ribosomal protein gene in Drosophila is RpS24. A small number of genetic reagents have been generated for Dmel\RpS24 including RNAi-targeting constructs and alleles caused by insertional mutagenesis.The RpS24 gene is haploinsufficient: heterozygous mutants display the 'Minute' phenotype, characterized by a slower developmental rate and small adult bristles. Knockdown of Dmel\RpS24 specifically in developing cardiac cells, effected by RNAi, results in detectable heart development defects in larvae and 100% lethality by the third larval instar stage.
[updated Sep. 2023 by FlyBase; FBrf0222196]
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. RPS24 encodes a ribosomal protein that is a component of the 40S subunit. [Gene Cards, RPS24; 2022.02.06]
One to one: 1 human gene to 1 Drosophila gene.
High-scoring ortholog of human RPS24 (1 Drosophila to 1 human).
