From rd120@XXXX Wed Apr 18 16:16:04 2001 Envelope-to: rd120@XXXX To: karpen@XXXX Subject: Helping FlyBase: Scim genes Hi Gary, I'm writing to you about the new Scim genes in your paper (Dobie et al.) in April's Genetics (Vol 157 number 4 page 1623). Table 3 lists 34 new genes.. Thing is \- I bet you know which CG genes at least some of these 'new' Scim genes map to. I know that you appreciate how we would prefer not to make new records for genes already represented by a CG entry in FlyBase, so if you could send me the correspondences I would be most grateful. The Scim-type names would override the CG ones, which would become synonyms. Feel free to pass this mail on to Kenneth if it is more reasonable for me to be asking him than you \- you are corresponding author so you get it first! all the best, Rachel. From karpen@XXXX Wed Apr 18 21:05:14 2001 To: Rachel Drysdale (Genetics) <rd120@XXXX> Subject: Re: Helping FlyBase: Scim genes Hi Rachel This should do the trick. Gary \-- Dr. Gary H. Karpen Associate Professor MBVL The Salk Institute 10010 North Torrey Pines Road La Jolla, CA 92037 Ph: 858-453-4100 ext 1473 Fax: 858-622-0417 Email: karpen@XXXX Web:http: //pingu.salk.edu/users/Karpen_web/Karpen_lab_home.html Dominant modifiers of J21A inheritance in novel loci ______________________________________________________________________________ Line Dm CG# Function Hs Genes Function / Disorder ______________________________________________________________________________ Scim4 12497 receptor LDLR lipoprotein receptor/familial hyperc. 13758 G protein linked receptor CALCR calcitonin receptor/osteoporosis Scim5 15816 unknown \- Scim6 6999 unknown \- Scim7 13238 unknown \- Scim81 4004 unknown \- Scim82 4004 unknown \- Scim9 3587 unknown \- Scim10 14438 unknown KIAA0760 OLF-1/EBF associated zinc finger Scim11 1494 transporter ABCA4 Stargardt disease Scim121 9894 unknown \- Scim122 9894 unknown \- Scim123 9894 unknown \- Scim124 9894 unknown \- Scim125 9894 unknown \- Scim126 9894 unknown \- Scim127 9894 unknown \- Scim128 9894 unknown \- Scim131 9892 transporter ABCG1 ATP-binding cassette transporter Scim132 9892 transporter ABCG1 cholesterol & phospholipid transport Scim141 13791 unknown \- Scim142 13791 unknown \- Scim151 4026 enzyme ITPKA cellular signalling Scim152 4026 enzyme ITPKA cellular signalling Scim16 13143 unknown \- 6187 unknown C18B11 Scim17 17745 unknown \- Scim18 16798 unknown \- Scim19 9241 unknown Cdc23(pombe) DNA replication 9242 enzyme GMPS catalyzes amination of XMP to GMP Scim20 12110 enzyme PLD1 PC-specific activity (inc. mitosis) 8276 unknown \- Scim21 9397 unknown \- Scim22 3268 hom trans DKFZP564F013 factor Scim23 8709 DNA replication KIAA0249 factor Scim24 6751 unknown (WD40) TAFII100 7704(Med)transcription MADH4 Pancreatic and intestinal cancer factor Scim25 8151 RNA pol II GTF2H1 Initiation of transcription tran factor 13941 signal transduction ARC activity-regulated cytoskeleton Scim26 13942 unknown \- 8603 motor/ AXPL cytoskeleton Scim27 10939 unknown SLC9A3R2 tyrosine kinase activator protein Scim28 13438 unknown \- Scim29 2852 chaperone PPIB cyclosporin A-mediated immunosup 13513 unknown \- Scim30 17816 unknown \- 10092 arginine-tRNA \- ligase Scim31 4029 transcription WHN T-cell immunodeficiency, alopecia factor Scim321 10120 malate ME1 dehydrogenase Scim322 10120 malate ME1 dehydrogenase Scim33 7682 unknown \- 7679 transporter ATP6N1A ATPase, H+ transporting, lysosomal Scim34 5557 transcription ZNF45 zinc finger protein 45 factor Scim35 15690 unknown \- 17838 RNA binding protein HNRPR Scim36 6295 enzyme PNLIP pancreatic lipase deficiency Scim37 12425 unknown \- ______________________________________________________________________________ cdc23 (S.pombe) encodes a protein of 593 amino acids cdc23 is essential for viability 22% overall identity and many structural homologies with DNA43 (MCM10) in S.cerevisiae MCM10 is required for correct initiation of DNA synthesis at chromosomal origins of replication
