Duttaroy, A., Paul, A., Kundu, M., Belton, A. (2003). A Sod2 null mutation confers severely reduced adult life span in Drosophila.  Genetics 165(4): 2295--2299.

FBrf0167659

Research paper

A null mutation for the Sod2 gene, Sod2n283, was obtained in Drosophila melanogaster. Homozygous Sod2 null (Sodn283/Sodn283) adult flies survive up to 24 hr following eclosion, a phenotype reminiscent of mice, where Sod2-/- progeny suffer neonatal lethality. Sodn283/+ heterozygotes are sensitive to oxidative stress induced by paraquat treatment.

PMC1462872 (PMC) (EuropePMC)