FB2024_03 , released June 25, 2024
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Citation
Schmucker, D. (2003). Downstream of guidance receptors: Entering the Baroque period of axon guidance signaling.  Neuron 40(1): 4--5.
FlyBase ID
FBrf0178950
Publication Type
Review
Abstract
The Roundabout ("Robo") family of transmembrane proteins are the receptors and mediators of the repellent axon guidance signal Slit. However, the molecular mechanisms by which Robo signaling leads to growth cone or neuron repulsion are still poorly understood. A study by Fan et al. in this issue of Neuron expands the repertoire of Robo pathway components and stimulates a new look at axon guidance signaling in general.
PubMed ID
14527427
PubMed Central ID
DOI
10.1016/s0896-6273(03)00603-2
Related Publication(s)
Research paper

Slit stimulation recruits Dock and Pak to the roundabout receptor and increases Rac activity to regulate axon repulsion at the CNS midline.
Fan et al., 2003, Neuron 40(1): 113--127 [FBrf0167957]

Slit stimulation recruits Dock and Pak to the roundabout receptor and increases Rac activity to regulate axon repulsion at the CNS midline.
Fan et al., 2003, Neuron 40(1): 113--127 [FBrf0167957]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Neuron
    Title
    Neuron
    Publication Year
    1988-
    ISBN/ISSN
    0896-6273
    Data From Reference
    Genes (6)