Personal communication from: S. Marygold
Subject: Ribosomal protein nomenclature in D.melanogaster.
Date: Wed, 8 Sep 2004
1. Our RP expert Naoya Kenmochi confirmed to me that 'Human MRPL42 and
MRPS32 are the same. I suggest that you take mRpL42 for this protein
to avoid any confusion'. If we can't do what he suggests (because this
gene is already known as 'mRpS32' in FB), can we add 'mRpL42' as a
synonym of mRpS32?
2. Naoya also confirmed what I thought about mRpS28 and mRpS35 being the
wrong way round: 'CG5497 corresponds to human MRPS28 and CG2101 corresponds
to MRPS35.' So can we switch these names (ie. CG5497 = mRpS28;
CG2101=mRpS35)?
3. Naoya also had this to say about mRpS4: 'MRPS4 (C15orf12) was withdrawn
from the human MRP list. See
http://www.gene.ucl.ac.uk/nomenclature/genefamily/MRPs.html'. So I don't
think we should rename CG4866 as 'mRpS4'.
4. According to the weblink in point 3, we should rename 'mRpL7-L12' as
just mRpL12 so as to be consistent with the current naming convention.
5. RpL41 and CR30425 reports. These need to be merged and if there's going
to be a CG---- replacement for the 'CR30425', what will this be (just
CG30425?)?
6. mRpS18 genes. These fly genes (and their human counterparts) are
sufficiently divergent to warrant these genes being renamed as
follows:
mRpS18a (CG9688) should be renamed mRpS18C
mRpS18b (CG10757) should be renamed mRpS18B
mRpS18c (CG31450) should be renamed mRpS18A
That is, these three genes are not really 'paralogs' in the same sense
as RpL34a and RpL34b, for example. Rather, they are distinct genes
with only limited similarity between them, and the current FB names
don't really tally with their 'official' names of their human
orthologs.
7. CG33002 should be renamed mRpL27 (this is the only MRPL27 ortholog).
8. CG18767 should be renamed mRpL36 (this is the only MRpL36 ortholog).
9. mRpL2a (CG6547) should be renamed mRpL37 (this is the only MRpL37
ortholog. There is no official 'MRPL2a' classification).
10. mRpL3a (CG15871) should be renamed mRpL38 (this is the only MRPL38
ortholog. There is no official 'MRPL3a' classification).
11. mRpL5 (CG17166) should be renamed mRpL39 (this is the only MRPL39
ortholog. There is no official 'MRPL5' classification).
12. mRpL22-24 (CG5242) should be renamed mRpL40 (this is the only MRPL40
ortholog. There is no official 'MRPL22-24' classification).
13. CG12954 should be renamed mRpL41 (this is the only MRPL41 ortholog).
14. CG30481 should be renamed mRpL53 (this is the only MRPL53 ortholog).
Steven Marygold Ph.D.
Growth Regulation Laboratory (Rm 503),
Cancer Research UK London Research Institute,
44 Lincoln's Inn Fields,
LONDON, WC2A 3PX
U.K.
Tel: \+44 (0)20 7269 3351
Fax: \+44 (0)20 7269 3581