This reference has been retracted. Some or all of the associated data have been removed.
Mirouse, V., Christoforou, C.P., Fritsch, C., St Johnston, D., Ray, R.P. (2009). Dystroglycan and perlecan provide a basal cue required for epithelial polarity during energetic stress. Dev. Cell 16(1): 83--92.
FlyBase ID
FBrf0206791
Publication Type
Research paper
Abstract
Dystroglycan localizes to the basal domain of epithelial cells and has been reported to play a role in apical-basal polarity. Here, we show that Dystroglycan null mutant follicle cells have normal apical-basal polarity, but lose the planar polarity of their basal actin stress fibers, a phenotype it shares with Dystrophin mutants. However, unlike Dystrophin mutants, mutants in Dystroglycan or in its extracellular matrix ligand Perlecan lose polarity under energetic stress. The maintenance of epithelial polarity under energetic stress requires the activation of Myosin II by the cellular energy sensor AMPK. Starved Dystroglycan or Perlecan null cells activate AMPK normally, but do not activate Myosin II. Thus, Perlecan signaling through Dystroglycan may determine where Myosin II can be activated by AMPK, thereby providing the basal polarity cue for the low-energy epithelial polarity pathway. Since Dystroglycan is often downregulated in tumors, loss of this pathway may play a role in cancer progression.
Retraction Notice to: Dystroglycan and Perlecan Provide a Basal Cue Required for Epithelial Polarity during Energetic Stress.
Mirouse et al., 2013, Dev. Cell 27(2): 241 [FBrf0224617]
Associated Information
Comments
THIS PAPER HAS BEEN RETRACTED see associated retraction FBrf0224617. Data in Figs. 4, 5, 6F, 6H and 6J have been removed. All other data remain valid, and remain associated with the original paper in FlyBase.
