Xu, D., Woodfield, S.E., Lee, T.V., Fan, Y., Antonio, C., Bergmann, A. (2009). Genetic control of programmed cell death (apoptosis) in Drosophila. Fly 3(1): 78--90.
FlyBase ID
FBrf0215539
Publication Type
Review
Abstract
Programmed cell death, or apoptosis, is a highly conserved cellular process that has been intensively investigated in nematodes, flies and mammals. The genetic conservation, the low redundancy, the feasibility for high-throughput genetic screens and the identification of temporally and spatially regulated apoptotic responses make Drosophila melanogaster a great model for the study of apoptosis. Here, we review the key players of the cell death pathway in Drosophila and discuss their roles in apoptotic and non-apoptotic processes.
