FB2024_03 , released June 25, 2024
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Citation
Chamseddin, K.H., Khan, S.Q., Nguyen, M.L., Antosh, M., Morris, S.N., Kolli, S., Neretti, N., Helfand, S.L., Bauer, J.H. (2012). takeout-dependent longevity is associated with altered Juvenile Hormone signaling.  Mech. Ageing Dev. 133(11-12): 637--646.
FlyBase ID
FBrf0220268
Publication Type
Research paper
Abstract
In order to understand the molecular mechanisms of longevity regulation, we recently performed a screen designed to enrich for genes common to several longevity interventions. Using this approach, we identified the Drosophila melanogaster gene takeout. takeout is upregulated in a variety of long-lived flies, and extends life span when overexpressed. Here, we investigate the mechanisms of takeout-dependent longevity. takeout overexpression specifically in the fat body is sufficient to increase fly longevity and is additive to the longevity effects of Dietary Restriction. takeout long-lived flies do not show phenotypes often associated with increased longevity, such as enhanced stress resistance or major metabolic abnormalities. However, males exhibit greatly diminished courtship behavior, leading to a reduction in fertility. Interestingly, takeout contains a binding domain for Juvenile Hormone, a fly hormone that plays a role in the regulation of developmental transitions. Importantly, the longevity and courtship phenotypes of takeout overexpressing flies are reversed by treatment with the Juvenile Hormone analog methoprene. These data suggest that takeout is a key player in the tradeoff-switch between fertility and longevity. takeout may control fertility via modulation of courtship behavior. This regulation may occur through Juvenile Hormone binding to takeout and a subsequent reduction in Juvenile Hormone signaling activity.
PubMed ID
PubMed Central ID
PMC3518612 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Mech. Ageing Dev.
    Title
    Mechanisms of Ageing and Development
    Publication Year
    1972-
    ISBN/ISSN
    0047-6374
    Data From Reference
    Genes (1)