On 9 Feb 2015, Rui Sousa-Neves wrote: Dear Steven, Yes, this is perhaps the best option. Rui —- On 9 Feb 2015, Steven Marygold wrote: In doing a ‘merge’ of the FlyBase 'l(4)102CDd’ and ‘dati’ Gene Reports, all current l(4)102CDd alleles (ie. the alleles #1 and #2 you mention, together with an additional 9 mutations (#3-11) in FlyBase, curated from Hochman, 1971 (FBrf0022724) would automatically become alleles of the dati gene. However, as you say, this would be misleading as there’s no evidence that l(4)102CDd1 (or presumably alleles #3-11) specifically affect dati - they could be specific lethals within Df(4)BH or deletions (like l(4)102CDd2). So, I think it’s best (most accurate, least misleading) if I: i) leave the 'l(4)102CDd’ Gene Report intact, associated with alleles #1 and #3-11 ii) dissociate allele #2 from 'l(4)102CDd’, making it a deletion (Df(4)BH) with a break in dati, based on your recent paper iii) add a comment to both the 'l(4)102CDd’ and ‘dati’ Gene Reports explaining the (potential) relationship between the two, based on this exchange. —- On 8 Feb 2015, Rui Sousa-Neves wrote: Dear Steven, Thanks for your message. That is an interesting question. l(4)102CDd existed as a gene with two alleles that failed to complement each other, l(4)102CDd1 and l(4)102CDd2. However, we now know that the only extant allele of this gene (i.e. l(4)102CDd2) is a deficiency (Df(4)BH). We do not know whether l(4)102CDd1 was a single lethal inside Df(4)BH or also a deletion - this allele could be either become a gene (l(4)102CDd1) with molecular limits within Df(4)BH or eliminated altogether since it was lost. Cheers Rui —- On Fri, Feb 6, 2015, Steven Marygold wrote: Dear Rui Sousa-Neves, I am curating your recent article titled: The KRUPPEL-Like Transcription Factor DATILOGRAFO Is Required in Specific Cholinergic Neurons for Sexual Receptivity in Drosophila Females. for FlyBase. Based on this, I am wondering whether I should merge the 'l(4)102CDd’ gene (FBgn0004520) with the dati gene in FlyBase? That is, do you think the current data in the 'l(4)102CDd’ Gene Report should all be associated with the ‘dati’ Gene Report, or should we maintain ‘l(4)102CDd’ as a separate entity? Thanks for your time, Steven. — Steven Marygold, Ph.D. FlyBase