Ferree, P.L., Di Talia, S. (2017). For Embryos, Mother Can Only Take You So Far.  Dev. Cell 42(3): 203--205.

FBrf0236334

Note

Early embryonic development is characterized by rapid cleavage divisions, which impose significant constraints on metabolic pathways. In this issue, Song et al. (2017) show that Drosophila embryos synthesize a large fraction of nucleotides on the go and that negative feedback between dATP and ribonucleotide reductase ensures tight control of dNTP concentration.