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Term | polypeptide N-acetylgalactosaminyltransferase activity | ID (Ontology) | GO:0004653 (Gene Ontology) | ||||||||||||||
Definition | Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis.[ EC:2 ISBN:0879695595 ] | ||||||||||||||||
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catalytic activity |__catalytic activity, acting on a protein___ UDP-glycosyltransferase activity | |__acetylgalactosaminyltransferase activity__| hexosyltransferase activity | |__acetylgalactosaminyltransferase activity__| polypeptide N-acetylgalactosaminyltransferase activity 13 rec. |
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acetylgalactosaminyltransferase activity catalytic activity, acting on a protein |
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EC:2.4.1.41 MetaCyc:2.4.1.41-RXN Reactome:R-HSA-5096532 "Defective GALNT12 does not transfer GalNAc to mucins" Reactome:R-HSA-5096537 "Defective GALNT3 does not transfer GalNAc to mucins" Reactome:R-HSA-8851619 "GALNT3 transfers GalNAc to FGF23" Reactome:R-HSA-913675 "GALNTs transfer GalNAc to Mucins to form Tn antigens" Reactome:R-HSA-9683760 "GalNAc is transferred onto 3a" Reactome:R-HSA-9694438 "GalNAc is transferred onto 3a" |