FB2024_03 , released June 25, 2024
FB2024_03 , released June 25, 2024
CV Term Report
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General Information
Term heterochromatin formation ID (Ontology) GO:0031507 (Gene Ontology)
Definition An epigenetic gene silencing mechanism in which chromatin is compacted into heterochromatin, resulting in a chromatin conformation refractory to transcription. This process starts with heterochromatin nucleation, its spreading, and ends with heterochromatin boundary formation.[ PubMed:25192661 PubMed:33827924 ]
Also Known As "chromatin silencing" ; "chromatin-mediated silencing" ; "establishment of heterochromatin architecture" (for all, see Synonyms field below)
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS     107
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 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 heterochromatin formation (all annotations which use CV term, excluding "NOT" statements)       8    107
     involved_in | heterochromatin formation       --     107
Spanning Tree (Parents/Children)
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negative regulation of gene expression____
epigenetic regulation of gene expression__|
                                          negative regulation of gene expression, epigenetic
                                           |__heterochromatin formation  170 rec.
                                               |__constitutive heterochromatin formation 12 rec.
                                               |   |__pericentric heterochromatin formation(+) 6 rec.
                                               |   |__silent mating-type cassette heterochromatin formation(+)
                                               |   |__subtelomeric heterochromatin formation 6 rec.
                                               |__dosage compensation by inactivation of X chromosome
                                               |   |__inactivation of paternal X chromosome by genomic imprinting
                                               |   |__random inactivation of X chromosome
                                               |__facultative heterochromatin formation 19 rec.
                                               |   |__DNA methylation-dependent heterochromatin formation(+) 12 rec.
                                               |   |__piRNA-mediated facultative heterochromatin formation
                                               |   |__rDNA heterochromatin formation(+) 1 rec.
                                               |   |__siRNA-independent facultative heterochromatin formation(+)
                                               |   |__siRNA-mediated facultative heterochromatin formation(+)
                                               |__heterochromatin boundary formation 11 rec.
                                               |__pericentric heterochromatin organization
                                               |__regulation of heterochromatin formation 26 rec.
                                               |   |__negative regulation of heterochromatin formation(+) 7 rec.
                                               |   |__positive regulation of heterochromatin formation(+) 17 rec.
                                               |   |__regulation of DNA methylation-dependent heterochromatin formation(+) 10 rec.
                                               |   |__regulation of pericentric heterochromatin formation(+) 2 rec.
                                               |   |__regulation of rDNA heterochromatin formation(+)
                                               |   |__regulation of regulatory ncRNA-mediated heterochromatin formation(+)
                                               |   |__regulation of silent mating-type cassette heterochromatin formation(+)
                                               |   |__regulation of siRNA-independent facultative heterochromatin formation
                                               |__regulatory ncRNA-mediated heterochromatin formation 21 rec.
                                                   |__piRNA-mediated heterochromatin formation(+) 14 rec.
                                                   |__regulation of regulatory ncRNA-mediated heterochromatin formation(+)
                                                   |__siRNA-mediated heterochromatin formation(+) 2 rec.
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Is a negative regulation of gene expression, epigenetic
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Synonyms
  • "chromatin silencing" EXACT
    "chromatin-mediated silencing" EXACT
    "establishment of chromatin silencing" RELATED
    "establishment of heterochromatic silencing" RELATED
    "establishment of heterochromatin architecture" EXACT
    "establishment of heterochromatin architecture involved in chromatin silencing at centromere outer repeat region" NARROW
    "establishment of heterochromatin architecture involved in chromatin silencing at pericentric region" NARROW
    "heterochromatic silencing" RELATED
    "heterochromatin assembly" EXACT
    "heterochromatin assembly involved in chromatin silencing" RELATED
    "heterochromatin assembly involved in chromatin silencing at centromere outer repeat region" NARROW
    "heterochromatin assembly involved in chromatin silencing at pericentric region" NARROW
    "heterochromatin formation involved in chromatin silencing" RELATED
    "heterochromatin formation involved in chromatin silencing at centromere outer repeat region" NARROW
    "heterochromatin formation involved in chromatin silencing at pericentric region" NARROW
    "heterochromatin maintenance" BROAD
    "TGS" BROAD
    "transcriptional gene silencing" RELATED
Secondary IDs
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