General Information
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Term |
alpha-ketoacid dehydrogenase complex |
ID (Ontology) |
GO:0045240 (Gene Ontology) |
Definition |
A multi-enzyme complex that catalyzes the oxidative decarboxylation of an alpha-ketoacid - pyruvate, a branched-chain alpha-ketoacid or alpha-ketoglutarate (also known as 2-oxoglutarate). The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: a dihydrolipoyl transacylase (E2) forms the core of the complex, with an alpha-ketoacid dehydrogenase (E1) and a dihydrolipoamide dehydrogenase (E3) attached through non-covalent bonds. The E1 and E2 components are specific to different alpha-ketoacid dehydrogenase complexes, whereas the E3 component is the same. Additional proteins may also be present.[ PubMed:10745006 ] |
Also Known As |
"2-oxoacid dehydrogenase complex" ; "dihydrolipoyl dehydrogenase complex" |
Comment |
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Links to Extrernal Ontologies
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QuickGO data AmiGO data
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Annotations
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Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
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No relevant records available
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Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
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Full annotation statements | Relevant FlyBase reports |
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Gene Groups |
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alpha-ketoacid dehydrogenase complex (all annotations which use CV term, excluding "NOT" statements) | 1 |
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