FB2024_03 , released June 25, 2024
FB2024_03 , released June 25, 2024
CV Term Report
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General Information
Term RNA polymerase II preinitiation complex assembly ID (Ontology) GO:0051123 (Gene Ontology)
Definition The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC) (which may include TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and TFIIH complexes). The PIC engages RNA polymerase II on its DNA template strand and sparks polymerization of the first few RNA nucleotides of the nascent transcript, of which 8 are base-paired with the DNA template within a DNA bubble. PIC assembly may result in a pause step, which marks the end of the PIC assembly and may be followed by promoter clearance (exact synonym: promoter escape). For RNA polymerase II PIC assembly is preceded by the formation of a nucleosome-free region that allows the transcription machinery to access the promoter DNA.[ PubMed:15020047 PubMed:31300188 ]
Also Known As "RNA polymerase II transcription PIC biosynthesis" ; "RNA polymerase II transcription PIC formation" ; "RNA polymerase II transcriptional preinitiation complex assembly" (for all, see Synonyms field below)
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS      14
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 Genes
 RNA polymerase II preinitiation complex assembly (all annotations which use CV term, excluding "NOT" statements)      14
     involved_in | RNA polymerase II preinitiation complex assembly      14
Spanning Tree (Parents/Children)
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DNA-templated transcription initiation
 |__transcription initiation at RNA polymerase II promoter__
 |__transcription preinitiation complex assembly____________|
transcription by RNA polymerase II                          |
 |__transcription initiation at RNA polymerase II promoter__|
protein-DNA complex assembly                                |
 |__transcription preinitiation complex assembly____________|
                                                            RNA polymerase II preinitiation complex assembly  17 rec.
                                                             |__regulation of RNA polymerase II transcription preinitiation complex assembly 3 rec.
                                                                 |__negative regulation of RNA polymerase II transcription preinitiation complex assembly 1 rec.
                                                                 |__positive regulation of RNA polymerase II transcription preinitiation complex assembly 2 rec.
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Is a transcription preinitiation complex assembly
Part of transcription initiation at RNA polymerase II promoter
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Synonyms
  • "RNA polymerase II transcription PIC biosynthesis" EXACT
    "RNA polymerase II transcription PIC formation" EXACT
    "RNA polymerase II transcriptional preinitiation complex assembly" EXACT
    "RNA polymerase II transcriptional preinitiation complex formation" EXACT
Secondary IDs
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