FB2024_03 , released June 25, 2024
Aberration: Dmel\Df(2L)ed-dp
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General Information
Symbol
Df(2L)ed-dp
Species
D. melanogaster
Name
Deficiency (2L) echinoid to dumpy
FlyBase ID
FBab0001791
Feature type
chromosomal_deletion
Also Known As
Df(2L)ed dph1, Df(2L)ed-dph1, Df(2L)ed-dph1
Computed Breakpoints include

24C3;25A2

Features within 24C3--25A2
Sequence coordinates
2L:3,786,772..3,790,223 [+] (Df(2L)ed-dp:bk1)
(Wang and Coulter, 1996)
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Mutagen
X ray
Class of aberration (relative to wild type)
chromosomal_deletion
(FlyBase, 2007)
Class of aberration (relative to progenitor)
chromosomal_deletion
(Pauli et al., 1995, Stern and Ganetzky, 1992, Schupbach and Wieschaus, 1991, de Belle et al., 1989, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988, Semeshin and Szidonya, 1985)
Breakpoints

24C5;25A1-25A4

(Semeshin and Szidonya, 1985)

24C3-24C5;25A2-25A3

(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)

24C1-24C3;25A1-25A4

(Pauli et al., 1995, Schupbach and Wieschaus, 1991, Schupbach and Wieschaus, 1989)

24C3-24C5;25A1-25A4

(de Belle et al., 1989)

24C2-24C9;25A1-25A2

(Stern and Ganetzky, 1992)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data

bowl << bk1 << fs(2)ltoQE45 << dp << bk2 << slf

Genetic mapping information
Comments

This deletion removes multiple ribosomal protein-coding genes (in addition to other genes).

(Marygold et al., 2007)

Breakpoint 1 was mapped to a XhoI-XhoI restriction fragment. The position of the restriction fragment on the reference sequence was inferred by a FlyBase curator.

(Wang and Coulter, 1996)
Comments on Cytology

Distal breakpoint is 5' of the bowl polyadenylation site.

(Wang and Coulter, 1996)

Left limit of break 1 from polytene analysis (FBrf0047784) Right limit of break 1 from polytene analysis (FBrf0049878) Left limit of break 2 from polytene analysis (FBrf0047784) Right limit of break 2 from polytene analysis (FBrf0056564)

Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
capu
(de Belle et al., 1993, Schupbach and Wieschaus, 1991)
dpy
(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
dw-24E
(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
ed
(Bai et al., 2001, de Belle et al., 1993, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
fs(2)ltoQE45
(Schupbach and Wieschaus, 1991)
ft
(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
ine
(Stern and Ganetzky, 1992)
l(2)24CDa
(de Belle et al., 1993)
l(2)24CDb
(de Belle et al., 1993)
l(2)24Dc
(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
l(2)24Dd
(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
l(2)24De
(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
l(2)24Fa
(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
l(2)24Fc
(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
M(2)24D
(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
RpL27A
(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
slp1
(Spradling et al., 1999, BDGP Project Members, 1994-1999, de Belle et al., 1993)
Su(rst)E218
(Tanenbaum et al., 2000)
Su(var)2-8
(Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
Tps1
(Spradling et al., 1999, BDGP Project Members, 1994-1999, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
tutl
(Al-Anzi and Wyman, 2009, Bodily et al., 2001, Spradling et al., 1999, BDGP Project Members, 1994-1999, Szidonya and Reuter, 1988, Szidonya and Reuter, 1988)
Partially deleted / disrupted
Molecular Data
Completely deleted
mRpL27
(Marygold et al., 2007)
RpL27A
(Marygold et al., 2007)
RpL40
(Marygold et al., 2007)
Partially deleted
Genes NOT Deleted / Disrupted
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location
    Phenotypic Data
    In combination with other aberrations

    Df(2L)ed-dp/Df(2L)M24F11 transheterozygotes exhibit delayed ventral furrow invagination, mesoderm spreading defects and a malformed germ band.

    (Mathew et al., 2009)

    Df(2L)ed-dp/Df(2L)sc19-8 transheterozygotes exhibit delayed ventral furrow invagination, mesoderm spreading defects and a malformed germ band.

    (Mathew et al., 2009)

    Fails to complement Df(2L)tutl4.

    (Bodily et al., 2001)
    NOT in combination with other aberrations

    Df(2L)ed-dp embryos have normal commissures and longitudinal connectives.

    (Al-Anzi and Wyman, 2009)

    Approximately a quarter of embryos from Df(2L)ed-dp heterozygotes exhibit a delay in the invagination of the ventral furrow as compared to controls.

    (Mathew et al., 2009)

    Flies heterozygous for the deletion show a Minute bristle phenotype.

    (Marygold et al., 2007)

    Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome.

    (Coyne et al., 1998)

    Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovoD2.

    (Pauli et al., 1995)

    Reduced viability and fertility.

    (Szidonya and Reuter, 1988)
    Stocks (2)
    Notes on Origin
    Discoverer
     

    Isolated over Dp(2;2)B3 = Dp(2;2)23E2-3;26E2-F1.

    Balancer / Genotype Variants of the Aberration
     
    Separable Components
     
    Other Comments
     

    The Df(2L)ed-dp chromosome may act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{wvar}KR3-2", a stable "brown-red" variant of the P{3'WP-2,wvar}2Lt insertion), but the eye colour phenotype in the presence of Df(2L)ed-dp overlaps the eye colour phenotype in a wild-type background so it cannot be unequivocally demonstrated that the deficiency chromosome uncovers a suppressor of telomeric silencing.

    (Mason et al., 2004)
    Synonyms and Secondary IDs (14)
    References (38)