FB2024_03 , released June 25, 2024
Aberration: Dmel\Df(2R)en30
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General Information
Symbol
Df(2R)en30
Species
D. melanogaster
Name
Deficiency (2R) engrailed
FlyBase ID
FBab0002176
Feature type
chromosomal_deletion
Also Known As
en30, en30, Df(2R)en-30
Computed Breakpoints include

48A3;48C6-48C8

Features within 48A3--48C8
Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Mutagen
gamma ray
Class of aberration (relative to wild type)
chromosomal_deletion
(FlyBase, 2007)
Class of aberration (relative to progenitor)
chromosomal_deletion
(Sinclair et al., 1998, Boube et al., 1997, Mulligan et al., 1996, Harbecke and Lengyel, 1995, Kania et al., 1995, Pauli et al., 1995, Bownes and Roberts, 1981)
Breakpoints

48A;48C6-48C8

(Bownes and Roberts, 1981)

48A3-48A4;48C6-48C8

(Sinclair et al., 1998, Mulligan et al., 1996, Harbecke and Lengyel, 1995, Kania et al., 1995, Pauli et al., 1995)

48A3-48A4;48C2-48C5

(Boube et al., 1997)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data

bk1 hits en << bk2 << Ef1α48D

Genetic mapping information
Comments

Left breakpoint between DNA coordinates 13 and 20 kb (Kuner et al., 1985).

Comments on Cytology

Ref: Lindsley and Zimm, 1992

(Kania et al., 1995)

Left limit of break 1 from polytene analysis (FBrf0080145) Right limit of break 1 from inclusion of en (FBrf0033228) Limits of break 2 from polytene analysis (FBrf0036848)

Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
obk
(Dworkin et al., 2001)
Partially deleted / disrupted
E(Pc)
(Sato et al., 1983)
en
(Eberlein and Russell, 1983, Russell and Eberlein, 1979)
Molecular Data
Completely deleted
Partially deleted
Genes NOT Deleted / Disrupted
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location
    Phenotypic Data
    In combination with other aberrations
    NOT in combination with other aberrations

    The Df(2R)en30 chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{wvar}KR3-2", a stable "brown-red" variant of the P{3'WP-2,wvar}2Lt insertion).

    (Mason et al., 2004)

    Heterozygosity for Df(2R)en30 results in 0.2% X chromosome nondisjunction and 0.5% fourth chromosome nondisjunction in In(1)FM7/X ; svspa-pol females.

    (Harris et al., 2003)

    Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome.

    (Coyne et al., 1998)

    No second site non-complementing phenotype with zipEbr and zipmhc-c6.1.

    (Halsell and Kiehart, 1998)

    Shows no maternal enhancement of dpphr4.

    (Nicholls and Gelbart, 1998)

    Shows a dose-sensitive interaction with pbhs.PB.

    (Boube et al., 1997)

    Transheterozygotes with enEnci have reduced adult viability and wings with vein defects in the posterior compartment. en mutants can be ranked by strength regarding their ability to induce a ci phenotype: en1 <= Df(2R)en30 <= en4 <= enEnci <= Df(2R)en-SFX31 <= en59.

    (Locke and Hanna, 1996)

    Deficient embryos show an uninterpretable mutant midgut phenotype.

    (Bilder and Scott, 1995)

    Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovoD2.

    (Pauli et al., 1995)

    Homozygous lethal. Heterozygotes with lethal en alleles are viable but exhibit wing abnormalities.

    (Eberlein and Russell, 1983)

    Homozygous lethal.

    (Russell and Eberlein, 1979)

    Homozygous viable

    Stocks (3)
    Notes on Origin
    Discoverer

    Eberlein and Russell.

     
    Balancer / Genotype Variants of the Aberration
     
    Separable Components
     
    Other Comments
     

    Claimed to be a viable allele by Kuner et al. despite claimed deficiency and failure to test homozygote by Eberlein and Russell. (Kuner et al., 1985)

    Synonyms and Secondary IDs (7)
    References (45)