FlyBase Aberration Report: Dmel\Df(2R)B65

General Information

Symbol

Df(2R)B65

Species

D. melanogaster

Name

FlyBase ID

FBab0047219

Feature type

chromosomal_deletion

Also Known As

Sema-2a^B65

Computed Breakpoints include

Features within 53C4--53C8 (Estimated cytology)

Genomic Maps

JBrowse

Sequence coordinates

2R:16,431,888..16,431,888 (Df(2R)B65:bk1)

(Wu et al., 2011)

2R:16,567,403..16,567,403 (Df(2R)B65:bk2)

(Wu et al., 2011)

Member of large scale dataset(s)

Nature of Aberration

Cytological Order

Progenitor

PBac{WH}CG4945^f02115

(Wu et al., 2011)

P{XP}jtb^d00549

(Wu et al., 2011)

Mutagen

FLPase

(Wu et al., 2011, Wu et al., 2011)

Class of aberration (relative to wild type)

chromosomal_deletion

(Wu et al., 2011)

Class of aberration (relative to progenitor)

chromosomal_deletion

(Wu et al., 2011)

Breakpoints

Causes alleles

Carries alleles

Transposon Insertions

Formalized genetic data

Genetic mapping information

Comments

Scer\FRT-mediated recombination between the two progenitor insertions has resulted in the deletion of the genomic sequence between them.

(Wu et al., 2011)

Scer\FRT-mediated recombination between the two progenitor insertions has resulted in the deletion of the genomic sequence between them.

(Wu et al., 2011)

Comments on Cytology

Sequence Crossreferences

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Gene Deletion and Duplication Data

Genes Deleted / Disrupted

Complementation Data

Completely deleted / disrupted

Partially deleted / disrupted

Molecular Data

Completely deleted

(Wu et al., 2011)

(Wu et al., 2011)

(Wu et al., 2011)

(Wu et al., 2011)

(Wu et al., 2011)

(Wu et al., 2011)

(Wu et al., 2011)

(Wu et al., 2011)

(Wu et al., 2011)

(Wu et al., 2011)

(Wu et al., 2011)

(Wu et al., 2011)

(Wu et al., 2011)

(Wu et al., 2011)

Partially deleted

Genes NOT Deleted / Disrupted

Complementation Data

Molecular Data

(Wu et al., 2011)

(Wu et al., 2011)

(Wu et al., 2011)

(Wu et al., 2011)

(Wu et al., 2011)

Genes Duplicated

Complementation Data

Completely duplicated

Partially duplicated

Molecular Data

Completely duplicated

Partially duplicated

Genes NOT Duplicated

Complementation Data

Molecular Data

Affected Genes Inferred by Location (16)

Related Comments

Phenotypic Data

In combination with other aberrations

Only 10.6% of hemisegments show disorganisation of the intermediate Fas2-positive longitudinal tract in Df(2R)Sema2b-C4/Df(2R)B65 embryos.

(Wu et al., 2011)

NOT in combination with other aberrations

ISNb axons of homozygous Df(2R)B65 mutant embryos show frequent defasciculation defects at muscle 12, innervation defects at muscles 6/7, and abnormal growth cone morphologies, as compared to controls. SNa axons of homozygous Df(2R)B65 mutant embryos sometimes fail to innervate muscle 24, resulting in a 'stall' phenotype, as compared to controls.

(Roh et al., 2016)

This deficiency includes a haploinsufficient locus, manifest as a dominant male sterility phenotype.

(Wu, 2016.8.29)

36.4% of hemisegments show disorganisation of the intermediate Fas2-positive longitudinal tract in homozygous embryos. Some chordotonal organ axons show ectopic projections medially in the central nervous system.

(Wu et al., 2011)

Stocks (1)

Bloomington

65746

w^*; Df(2R)B65, Dp(2;2)IbaS, PBac{IbaS}VK00001/CyO, P{GAL4-twi.G}2.2, P{UAS-2xEGFP}AH2.2

Notes on Origin

Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

B65

(Meltzer et al., 2016)

Df(2R)B65

(Wu, 2016.8.29)

FDD-000938

(Wu et al., 2011, Wu et al., 2011)

Sema-2a^B65

(Jeong et al., 2017, Roh et al., 2016, Wu et al., 2011)

Sema2a^B65

(Wu et al., 2011)

sema-2a^B65

(Hernandez-Fleming et al., 2017)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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