FlyBase Allele Report: Dmel\Actn[14]

General Information

Symbol

Dmel\Actn¹⁴

Species

D. melanogaster

Name

FlyBase ID

FBal0000288

Feature type

allele

Associated gene

Dmel\Actn

Associated Insertion(s)

Carried in Construct

Also Known As

l(1)EA82, EA82

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Dubreuil and Wang, 2000)

lethal - all die before end of larval stage

(Stronach et al., 1999)

lethal - all die before end of larval stage | recessive

(Perrimon et al., 1989, Perrimon et al., 1985)

some die during larval stage

(Stronach et al., 1999)

some die during larval stage | recessive

(Perrimon et al., 1989, Perrimon et al., 1985)

viable, with Actn^RpS27A.PD

(Dubreuil and Wang, 2000)

Phenotype Manifest In

actin filament & follicle cell | somatic clone

(Wahlstrom et al., 2006)

sarcomere

(Jani and Schock, 2007)

Detailed Description

Statement

Reference

In 1 day old Actn¹⁴ larvae, Z lines are observed spaced at regular, but wider, intervals than in the wild-type in ultrastructural analysis of the muscles.

(Jani and Schock, 2007)

Actn¹⁴ follicle cell clones do not result in the production of abnormal eggs. At stage 10, some of these clones show a normal actin fiber pattern, while others show an actin fiber density that differs from wild-type cells. Any differences in actin density are cell autonomous.

(Wahlstrom et al., 2006)

Phenotype of homozygous germ line clones demonstrates is there is no maternal effect.

(Perrimon et al., 1985)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

Actn¹⁴ has lethal | recessive phenotype, non-suppressible by α-Spec::Actn^19.RpS27A

(Dubreuil and Wang, 2000)

Actn¹⁴ has lethal | recessive phenotype, non-suppressible by α-Spec::Actn^EF.RpS27A

(Dubreuil and Wang, 2000)

Actn¹⁴ has lethal | recessive phenotype, non-suppressible by β-Spec::Actn^{ABD.RpS27A.Tag:MYC}

(Dubreuil and Wang, 2000)

Other

Statement

Reference

Actn¹⁴, vri[+]/vri^unspecified has abnormal locomotor behavior | dominant phenotype

(Szuplewski et al., 2003)

Actn¹⁴/Actn[+], vri^unspecified has abnormal locomotor behavior phenotype

(Szuplewski et al., 2003)

α-Spec::Actn^19.RpS27A, Actn¹⁴ has viable phenotype

(Dubreuil and Wang, 2000)

Actn¹⁴, wupA^hdp-2 has flightless | dominant phenotype

(Homyk and Emerson, 1988)

Phenotype Manifest In

Enhancer of

Statement

Reference

Actn¹⁴/Actn[+] is an enhancer of visceral muscle fiber phenotype of tn^MJO-348

(Domsch et al., 2013)

Actn¹⁴/Actn[+] is an enhancer of filamentous actin phenotype of tn^MJO-348

(Domsch et al., 2013)

NOT Enhancer of

Statement

Reference

Actn¹⁴/Actn[+] is a non-enhancer of visceral muscle fiber phenotype of tn^MJO-348

(Domsch et al., 2013)

Actn¹⁴/Actn[+] is a non-enhancer of filamentous actin phenotype of tn^MJO-348

(Domsch et al., 2013)

Other

Statement

Reference

Actn¹⁴, vri^unspecified has metathoracic leg phenotype

(Szuplewski et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

Larvae heterozygous for Actn¹⁴ and tn^MJO-348 display normal F-actin striations. By comparison, tn^MJO-348 mutants in a Actn¹⁴ heterozygous background display more extensive disorganisation, indicating enhancement of the tn mutant phenotype.

(Domsch et al., 2013)

Actn¹⁴ vri^unspecified double heterozygotes have progressive locomotory defects affecting the rear legs.

(Szuplewski et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Actn¹⁴ is rescued by Actn^RpS27A.PD

(Dubreuil and Wang, 2000)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

4655

Actn¹⁴/FM7a

Kyoto

107829

Actn¹⁴/FM7a

Notes on Origin

Discoverer

Lefevre.

Comments

Maternal germline clonal analysis demonstrates there is no maternal effect.

(Perrimon et al., 1989)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Actn¹⁴

(Sekine et al., 2024, Fernandes and Schöck, 2014, Popodi et al., 2010-, Jani and Schock, 2007, Wahlstrom et al., 2006)

EA82

(Perrimon et al., 1989, Homyk and Emerson, 1988)

actn¹⁴

(Domsch et al., 2013)

actn^EA82

(Dubreuil and Wang, 2000)

l(1)EA82

(Stronach et al., 1999, Fyrberg and Beall, 1990, Fyrberg et al., 1988, Perrimon et al., 1985)

Name Synonyms

Secondary FlyBase IDs

References (15)

Report Sections

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