FB2024_03 , released June 25, 2024
Allele: Dmel\ap78j
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General Information
Symbol
Dmel\ap78j
Species
D. melanogaster
Name
FlyBase ID
FBal0000653
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

ap78j/ap54 flies show wing margin and size reductions characteristic of weak ap mutations.

Temperature-sensitive allele. Histolysis of the larval fat body is essentially normal in homozygous females kept at the restrictive temperature (25oC).

When raised at 22oC, wing and haltere phenotype approaches wild type except for missing patches of triple-row bristles and posterior wing margin. When raised at higher temperatures, phenotype becomes more severe and resembles ap4 at 29oC. Two nonoverlapping temperature-sensitive periods in development, one in late-second to middle-third instar for wing and haltere deficiency phenotype and the other during the first day of pupal development for precocious adult death and nonvitellogenesis phenotype. Wing discs of heat-pulsed larvae failed to exhibit cell death by trypan blue exclusion.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

ap54/ap78j has visible phenotype, enhanceable by Chi[+]/ChiM4

Suppressed by
Statement
Reference

ap78j has visible | dominant phenotype, suppressible by wg1/fz3G10

Enhancer of
Statement
Reference

ap78j is an enhancer of visible | recessive phenotype of wg1

Other
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference

ap54/ap78j has wing phenotype, enhanceable by Chi[+]/ChiM4

Suppressed by
Statement
Reference

ap78j has wing phenotype, suppressible by wg1/fz3G10

Enhancer of
Statement
Reference

ap78j is an enhancer of wing phenotype of wg1

Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

The wingless phenotype of wg1 homozygotes is dominantly enhanced by ap78j; no wing blade is formed at approximately 90% of presumptive wing-blade-forming sites. This phenotype is partially suppressed by fz3G10.

The ap78j/ap54 wing phenotype is enhanced by ChiM4 such that wing becomes rudimentary.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Wilson, Oct. 1978.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
ap78j
Name Synonyms
Secondary FlyBase IDs
    References (6)