FlyBase Allele Report: Dmel\BicD[1]

General Information

Symbol

Dmel\BicD¹

Species

D. melanogaster

Name

FlyBase ID

FBal0001140

Feature type

allele

Associated gene

Dmel\BicD

Associated Insertion(s)

Carried in Construct

Also Known As

BicD⁷¹³⁴, Bic-D^71.34, BicD^71.34

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Tearle and Nusslein-Volhard, 1987)

Progenitor genotype

Cytology

Description

Nucleotide substitution: TTC to ATC Amino acid replacement: F684I.

(Wharton and Struhl, 1989)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:17,462,435..17,462,435 [-]

Nucleotide change:

T17462435A

Reported nucleotide change:

T?A

Amino acid change:

F684I | BicD-PA; F684I | BicD-PB; F684I | BicD-PC; F684I | BicD-PD

Reported amino acid change:

F684I

(Wharton and Struhl, 1989)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | dominant | maternal effect

(Ran et al., 1994)

Phenotype Manifest In

Detailed Description

Statement

Reference

BicD¹/BicD^r5 females show reduced enrichment of yolk granules at the posterior of stage 8-9 oocytes compared to wild type.

(Vazquez-Pianzola et al., 2014)

Heterozygous BicD¹ females produce 16% wild-type embryos and 84% embryos with various defects, including reduced mouthparts and bicaudal phenotypes.

(Vazquez-Pianzola et al., 2011)

Embryos derived from BicD¹/BicD² mothers show a duplication of posterior structures and a lack of anterior structures. These embryos lack macrophages. Apoptotic cells accumulate at the ventral surface of the central nervous system (CNS), and subperineural glia contain an abundance of apoptotic cells. Single unengulfed apoptotic cells are also seen inside the CNS. The number of subperineural glia per abdominal segment is not significantly different from wild-type in stage 16 embryos.

(Sonnenfeld and Jacobs, 1995)

Does not prevent the posterior localization of G-iα65A protein.

(Wolfgang and Forte, 1995)

Embryos from mutant females are bicaudal.

(Ran et al., 1994)

Hemocytes cannot be detected, suggesting that in the absence of head mesoderm the trunk population of mesoderm cannot produce hemocytes. Cellular debris becomes located in the extracellular space.

(Tepass et al., 1994)

Ectopic nos activity at the anterior pole of embryos derived from BicD¹ mutant females blocks bcd protein expression from bcd^Δ transcripts but not from bcd⁺ transcripts. None of the embryos bearing the bcd^Δ mRNA display the bcd phenotype.

(Wharton and Struhl, 1991)

Lack of head and thoracic anlagen is caused by the lack of bcd protein.

(Driever and Nusslein-Volhard, 1988)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

BicD¹ has embryo phenotype, suppressible by pAbp[+]/pAbp^k10109

(Vazquez-Pianzola et al., 2011)

BicD¹ has embryo phenotype, suppressible by pAbp^37-2/pAbp[+]

(Vazquez-Pianzola et al., 2011)

BicD¹, pAbp[+]/pAbp^k10109 has embryo phenotype, suppressible by pAbp^+t7.8

(Vazquez-Pianzola et al., 2011)

BicD¹, pAbp^37-2/pAbp[+] has embryo phenotype, suppressible by pAbp^+t7.8

(Vazquez-Pianzola et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

The BicD¹/+ mutant embryonic phenotypes are suppressed by pAbp^k10109/+.

The BicD¹/+ mutant embryonic phenotypes are suppressed by pAbp^37-2/+.

The suppression of the BicD¹/+ embryonic phenotypes by pAbp^k10109/+ is partially reverted by one copy of pAbp^+t7.8.

The suppression of the BicD¹/+ embryonic phenotypes by pAbp^37-2/+ is partially reverted by one copy of pAbp^+t7.8.

(Vazquez-Pianzola et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (5)

Bloomington

2988

dpy^ov1 b¹ BicD¹/CyO

3352

b¹ BicD¹ tor¹ cn¹/CyO

3244

b¹ BicD¹ tor^11D cn¹ bw¹/CyO

Kyoto

107510

dpy^ov1 b¹ BicD¹/CyO

106939

b¹ BicD¹ tor^11D cn¹ bw¹/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

Bic-D^71.34

(Vazquez-Pianzola et al., 2014, Vazquez-Pianzola et al., 2011, Nakamura et al., 1996, Sonnenfeld and Jacobs, 1995, Ran et al., 1994, Akiyama and Okada, 1992)

Bic-D⁷¹³⁴

(Hortsch et al., 1998, St. Johnston, 1993)

Bic-D^D71

(Ephrussi et al., 1991)

BicD¹

(Gáspár et al., 2023, Bhagavatula and Knust, 2021, Shapiro and Anderson, 2006)

BicD^71.34

(Oh et al., 2000, Mach and Lehmann, 1997, Kim-Ha et al., 1991, Suter and Steward, 1991, Wharton and Struhl, 1991)

BicD⁷¹³⁴

(Navarro et al., 2004, Inamdar, 2003, Mach and Lehmann, 1997, Jongens et al., 1994, Tepass et al., 1994, Jongens et al., 1992, St. Johnston et al., 1991, Hay et al., 1990, Lasko and Ashburner, 1990, Driever and Nusslein-Volhard, 1988, Tearle and Nusslein-Volhard, 1987)

BicD^D7134

(Morris et al., 1998)

BicaudalD⁷¹³⁴

(Jankovics et al., 2001)

Name Synonyms

Secondary FlyBase IDs

References (33)

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