FlyBase Allele Report: Dmel\BicD[r]

General Information

Symbol

Dmel\BicD^r

Species

D. melanogaster

Name

FlyBase ID

FBal0001142

Feature type

allele

Associated gene

Dmel\BicD

Associated Insertion(s)

Carried in Construct

Also Known As

Bic-D^PA66, BicD^PA66

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Swan and Suter, 1996, Lantz et al., 1994, Ran et al., 1994)

loss of function allele

(Digilio et al., 1996, Lantz et al., 1992, Schupbach and Wieschaus, 1991, Suter and Steward, 1991)

Mutagen

ethyl methanesulfonate

(Schupbach and Wieschaus, 1991)

Progenitor genotype

Cytology

Description

Amino acid replacement: A40V.

(Oh et al., 2000)

Codon 40 is changed from GCC to GTC causing an Ala to Val substitution.

(Suter and Steward, 1991)

sequenced by Suter and Steward, 1991

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:17,472,206..17,472,206 [-]

Nucleotide change:

C17472206T

Amino acid change:

A40V | BicD-PA; A40V | BicD-PB; A40V | BicD-PC; A40V | BicD-PD

Reported amino acid change:

A40V

(Oh et al., 2000, Suter and Steward, 1991)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

No Assay Recorded

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage & oogenesis

oocyte

(Suter and Steward, 1991)

cyst cell of ovary

(Suter and Steward, 1991)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage & oogenesis

nurse cell

(Suter and Steward, 1991)

germarium region 1

(Suter and Steward, 1991)

Additional Information

Statement

Reference

In BicD^r mutants, BicD protein does not localize to the oocyte.

(Suter and Steward, 1991)

In wild type females, BicD RNA is detected very early in oogenesis in the 16 cystocyte cluster and progressively accumulates in a single cell, the oocyte. In BicD^r mutants, BicD RNA does not localized to a single cystocyte, but is found in all of the pro-nurse cells.

(Suter and Steward, 1991)

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile

(Sass et al., 1995)

female sterile | recessive

(Lantz et al., 1994, Ran et al., 1994, Lantz et al., 1992, Schupbach and Wieschaus, 1991, Suter and Steward, 1991)

male fertile

(Schupbach and Wieschaus, 1991)

visible | adult stage | dominant

(Jejina et al., 2024)

Phenotype Manifest In

dorsal appendage

(Swan and Suter, 1996)

egg chamber

(Capri et al., 1997, Lantz et al., 1992)

egg chorion

(Schupbach and Wieschaus, 1991)

germline cyst

(Theurkauf et al., 1993)

macrochaeta

(Jejina et al., 2024)

oocyte

(Mirouse et al., 2006, Lantz et al., 1994, Lantz et al., 1992, Schupbach and Wieschaus, 1991)

ovary

(Digilio et al., 1996, Ran et al., 1994)

photoreceptor cell | precursor & nucleus

(Houalla et al., 2005)

Detailed Description

Statement

Reference

Meiosis is initiated normally in two to four cells in region 2a of the germarium in BicD^r homozygous females, but oocyte differentiation is blocked.

(Mirouse et al., 2006)

Mutant eye discs exhibit an R-cell precursor nucleus migration phenotype.

(Houalla et al., 2005)

Fusomes in the cysts of BicD^r/BicD^R26 ovaries appear to form normally.

(de Cuevas and Spradling, 1998)

Egg chambers of hemizygous females start to degenerate around stage 7.

(Capri et al., 1997)

Embryos exhibit a fused dorsal appendage.

(Swan and Suter, 1996)

Fusomes are normal.

(Lin et al., 1994)

16-nurse cell phenotype.

(Ran et al., 1994)

No single microtubule organizing center forms in the germaria of hemizygous females, instead several small foci are present. The actin cytoskeleton is unaffected.

(Theurkauf et al., 1993)

Egg chambers have 16 nurse cells and no oocyte. Egg chambers increase in size to stage 6. No chorion is formed.

(Schupbach and Wieschaus, 1991)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

BicDR^8.1, BicD^r has lethal phenotype

(Jejina et al., 2024)

BicDR⁵¹, BicD^r has lethal phenotype

(Jejina et al., 2024)

BicDR⁵¹, BicD^r has visible | adult stage phenotype

(Jejina et al., 2024)

BicD^r, Df(3L)BSC737 has lethal phenotype

(Jejina et al., 2024)

BicD^r, Df(3L)BSC737 has visible | adult stage phenotype

(Jejina et al., 2024)

BicD^r, eEF1γ^A28 has visible | adult stage phenotype

(Jejina et al., 2024)

BicD^r, eEF1γ^A70 has visible | adult stage phenotype

(Jejina et al., 2024)

BicDR^8.1, BicD^r has visible | adult stage phenotype

(Jejina et al., 2024)

BicD^r, eEF1γ^A15 has visible | adult stage phenotype

(Jejina et al., 2024)

BicDR⁷¹, BicD^r, eEF1γ^A15 has visible | adult stage phenotype

(Jejina et al., 2024)

BicDR⁷¹, BicD^r, eEF1γ^A28 has visible | adult stage phenotype

(Jejina et al., 2024)

BicDR⁷¹, BicD^r, eEF1γ^A70 has visible | adult stage phenotype

(Jejina et al., 2024)

BicDR⁷¹, BicD^r has partially lethal - majority die phenotype

(Jejina et al., 2024)

BicDR⁷¹, BicD^r has visible | adult stage phenotype

(Jejina et al., 2024)

BicDR²⁹, BicD^r has partially lethal - majority die phenotype

(Jejina et al., 2024)

BicDR²⁹, BicD^r has visible | adult stage phenotype

(Jejina et al., 2024)

Df(2L)TW119/BicD^r, DCTN1-p150^Gl-1 has lethal phenotype

(Swan et al., 1999)

Phenotype Manifest In

Enhanced by

Statement

Reference

BicD^r has phenotype, enhanceable by Lis-1[+]/Lis-1^E415

(Swan et al., 1999)

Suppressed by

Statement

Reference

BicD^r has oocyte phenotype, suppressible by Scer\GAL4^unspecified/polo^UASp.cMa

(Mirouse et al., 2006)

BicD^r has phenotype, suppressible by kst⁰¹³¹⁸

(Nguyen, 1997.4.17, Nguyen and Suter, 1997)

Suppressor of

Statement

Reference

Df(2L)TW119/BicD^r is a suppressor | partially of follicle cell phenotype of fs(1)186¹⁸⁶

(Swan et al., 2001)

Other

Statement

Reference

BicDR^8.1, BicD^r has macrochaeta phenotype

(Jejina et al., 2024)

BicDR⁵¹, BicD^r has macrochaeta phenotype

(Jejina et al., 2024)

BicD^r, Df(3L)BSC737 has macrochaeta phenotype

(Jejina et al., 2024)

BicD^r, eEF1γ^A28 has macrochaeta phenotype

(Jejina et al., 2024)

BicD^r, eEF1γ^A70 has macrochaeta phenotype

(Jejina et al., 2024)

BicD^r, eEF1γ^A15 has macrochaeta phenotype

(Jejina et al., 2024)

BicDR⁷¹, BicD^r, eEF1γ^A15 has macrochaeta phenotype

(Jejina et al., 2024)

BicDR⁷¹, BicD^r, eEF1γ^A28 has macrochaeta phenotype

(Jejina et al., 2024)

BicDR⁷¹, BicD^r, eEF1γ^A70 has macrochaeta phenotype

(Jejina et al., 2024)

BicDR⁷¹, BicD^r has macrochaeta phenotype

(Jejina et al., 2024)

BicDR⁷¹, BicD^r has filamentous actin phenotype

(Jejina et al., 2024)

BicDR²⁹, BicD^r has macrochaeta phenotype

(Jejina et al., 2024)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Not rescued by

BicD^r is not rescued by BicD^H4

(Oh et al., 2000)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Bic-D^PA66

(Houalla et al., 2005, Swan et al., 2001, Oh et al., 2000, Swan et al., 1999, de Cuevas and Spradling, 1998, Capri et al., 1997, Nguyen, 1997.4.17, Nguyen and Suter, 1997, Digilio et al., 1996, Swan and Suter, 1996, Baksa and Steward, 1995, Micklem, 1995, Sass et al., 1995, Lantz et al., 1994, Ran et al., 1994, Theurkauf, 1994, Theurkauf et al., 1993, Lantz et al., 1992)

BicD^PA66

(Jejina et al., 2024, Koch et al., 2009, Mirouse et al., 2006, Deng and Lin, 2001, Schonbaum et al., 2000, Mach and Lehmann, 1997, Fitzpatrick et al., 1995, Li et al., 1994, Lin et al., 1994, Suter and Steward, 1991)

BicD^r

Name Synonyms

Secondary FlyBase IDs

References (30)

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