FB2024_03 , released June 25, 2024
Allele: Dmel\Catn4
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General Information
Symbol
Dmel\Catn4
Species
D. melanogaster
Name
FlyBase ID
FBal0001551
Feature type
allele
Associated gene
Dmel\Cat
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Mackay and Bewley, 1989)
Mutagen
ethyl methanesulfonate
Progenitor genotype
Cytology
Description

Lacks the initiator AUG.

(Wheeler et al., 1995)

Nucleotide substitution: G139A. Amino acid replacement: M1I. Substitution changes the translation initiator from ATG to ATA.

(Griswold et al., 1993)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:18,822,788..18,822,788 [+]
Nucleotide change:

G18822788A

Reported nucleotide change:

G139A

Amino acid change:

M1I | Cat-PA

Reported amino acid change:

M1I

Comment:

A substitution changes the translation initiator from ATG to ATA.

(Wheeler et al., 1995, Griswold et al., 1993)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Catn1/Catn4 transheterozygotes are very sensitive to H2O2. Sensitivity is considerably attenuated in the presence of a single copy of P{Cat7.0}.

      (Orr et al., 1996)

      Exhibit gene dosage effect for catalase activity as a heterozygote.

      (Mackay and Bewley, 1989)

      CRM negative.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Catn4 is rescued by Cat+t7

      (Griswold et al., 1993)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      CatN4
      (Wheeler et al., 1995)
      Catn4
      catn4
      (Chew et al., 2021)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)