FlyBase Allele Report: Dmel\cd[1]

General Information

Symbol

Dmel\cd¹

Species

D. melanogaster

Name

FlyBase ID

FBal0001565

Feature type

allele

Associated gene

Dmel\cd

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Tearle, 1991)

Mutagen

spontaneous

ethyl methanesulfonate

(Tearle, 1991)

Progenitor genotype

Cytology

Description

cd¹ carries at least two non-functional cd copies: 1. cd(A) with T(20) > G change in the promoter area and a deletion disrupting the enzyme catalytic site; and 2. cd(B), for which the molecular nature of impairment remains unknown.

(Zhuravlev et al., 2022)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Campesan et al., 2011)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal eye color

(Tearle, 1991)

visible | recessive

(Tearle, 1991)

Phenotype Manifest In

eye

Malpighian tubule

pigment cell

(Tearle, 1991)

Detailed Description

Statement

Reference

Homozygous cd¹ mutant flies show increased levels of 3-hydroxykynurenine (3-HK) compared to controls. No rhabdomere degeneration is seen in homozygous cd¹ mutant flies.

(Campesan et al., 2011)

Mutant flies show a significant reduction in ommochrome pigment levels compared to wild type.

(Harris et al., 2011)

Eye colour: pale brown. Ocellus colour: white. Eyes are pale brown. Blocks pigmentation of the secondary pigment cells and causes excessive pigmentation of the primary pigment cells.

(Tearle, 1991)

Accumulates a blue-fluorescent compound termed cardinalic acid (xantherenic acid 8-O-β-O-glucoside).

(Ferre et al., 1985)

Phenoxazinone synthetase activity about 39% wild type; accumulates 3-hydroxykinurenine.

(Sullivan et al., 1974, Phillips et al., 1973)

Drosopterin content of eyes about 85% normal.

(Gearhart and MacIntyre, 1970)

Eye color autonomous in transplant of larval optic disk into wild type, ca, cn, st, or vlarval host.

(Beadle and Ephrussi, 1936)

Eye colour: yellowish vermilion, darkening to wild-type with age. Ocellus colour: white; not darkening with age. Malpighian tubule colour: bright yellow; not distinguishable from wild type. RK2.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

cd¹ is a suppressor of abnormal neuroanatomy | adult stage phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Campesan et al., 2011)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

cd¹ partially suppresses the rhabdomere degeneration seen when Hsap\HTT^{Q93.ex1p.Scer\UAS} is expressed under the control of Scer\GAL4^elav-C155 at both one day and seven days post-eclosion. 3-hydroxykynurenine (3-HK) levels are unchanged but kynurenic acid (KYNA) levels are significantly increased, resulting in a significant increase in the 3-HK/KYNA ratio.

(Campesan et al., 2011)

Complementation and Rescue Data

Comments

Images (2)

Holtzman, S. and Kaufman, T. (2013)

Mutant

Wild-type