FlyBase Allele Report: Dmel\cm[1]

General Information

Symbol

Dmel\cm¹

Species

D. melanogaster

Name

FlyBase ID

FBal0001720

Feature type

allele

Associated gene

Dmel\cm

Associated Insertion(s)

?{}cm¹

Carried in Construct

Also Known As

carmine¹

Key Links

Allele class

Mutagen

spontaneous

Nature of the Allele

Allele class

Mutagen

spontaneous

Progenitor genotype

Associated Insertion(s)

?{}cm¹

Cytology

Description

Insertion of 5kb into the cm open reading frame.

(Mullins et al., 1999)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Hermansky-Pudlak syndrome

modeled by Blos1^ex2

(Cheli et al., 2010)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal eye color

(Cheli et al., 2010)

abnormal eye color | recessive

(Mullins et al., 1999)

short lived | male

(Simonsen et al., 2007)

visible | recessive

(Mullins et al., 1999)

Phenotype Manifest In

Malpighian tubule

ommatidium

(Wang et al., 2014)

photoreceptor neuron

(Wang et al., 2014)

pigment cell

(Mullins et al., 1999)

rhabdomere

(Wang et al., 2014, Mullins et al., 1999)

secondary pigment cell pigment granule

(Mullins et al., 1999)

tertiary pigment cell pigment granule

(Mullins et al., 1999)

Detailed Description

Statement

Reference

Upon 6 days of exposure to continuous white light, cm¹ mutant photoreceptor cells show degenerative features, including a loss of rhabdomeres and disruption of ommatidial organization. cm¹ mutant photoreceptor cells exhibit decreased ERG amplitudes.

(Wang et al., 2014)

The glue granules in the salivary gland cells of cm¹ mutant third instar larvae are similar in size to wild type.

(Burgess et al., 2011)

Mutant flies have reduced red pigment in the eye compared to controls.

(Cheli et al., 2010)

Mutant males have a shortened adult life span compared to controls, with a mean life span of 21.97 days at 25^o.

(Simonsen et al., 2007)

Eye colour: darker than wild type. Dramatic reduction in number of secondary and tertiary pigment granules surrounding the ommatidium. Outer rhabdomeres are also occasionally missing.

(Mullins et al., 1999)

Eye colour: translucent dark ruby. Eye colour: deep orange, with st¹. Eye colour: lighter than bw¹, with bw¹. Malpighian tubule colour: very pale yellow. RK1.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

cm¹ has abnormal eye color phenotype, enhanceable by Blos1^ex2

(Cheli et al., 2010)

Enhancer of

Statement

Reference

cm¹ is an enhancer of abnormal eye color phenotype of Blos1^ex2

(Cheli et al., 2010)

Phenotype Manifest In

Suppressed by

Statement

Reference

cm¹ has rhabdomere phenotype, suppressible by Scer\GAL4^Act5C.PU/w^JF01901/Vps35^UAS.Tag:HA

(Wang et al., 2014)

cm¹ has ommatidium phenotype, suppressible by Scer\GAL4^Act5C.PU/w^JF01901/Vps35^UAS.Tag:HA

(Wang et al., 2014)

cm¹ has photoreceptor neuron phenotype, suppressible by Scer\GAL4^Act5C.PU/w^JF01901/Vps35^UAS.Tag:HA

(Wang et al., 2014)

cm¹ has rhabdomere phenotype, suppressible by Scer\GAL4^Act5C.PU/w^JF01901/Vps26^UAS.Tag:V5

(Wang et al., 2014)

cm¹ has ommatidium phenotype, suppressible by Scer\GAL4^Act5C.PU/w^JF01901/Vps26^UAS.Tag:V5

(Wang et al., 2014)

cm¹ has photoreceptor neuron phenotype, suppressible by Scer\GAL4^Act5C.PU/w^JF01901/Vps26^UAS.Tag:V5

(Wang et al., 2014)

NOT suppressed by

Statement

Reference

cm¹ has phenotype, non-suppressible by su(Hw)²

(Lindsley and Grell, 1968)

Additional Comments

Genetic Interactions

Statement

Reference

Overexpression of Vps35^{Scer\UAS.T:Ivir\HA1} in a Scer\GAL4^Act5C.PU w^JF01901 background, significantly restores rhabdomere number and suppresses the ERG amplitude defects found in cm¹ mutants that have been continuously exposed to white light for 6 days.

Overexpression of Vps26^{Scer\UAS.T:SV5\V5} in a Scer\GAL4^Act5C.PU w^JF01901 background, significantly restores rhabdomere number and suppresses the ERG amplitude defects found in cm¹ mutants that have been continuously exposed to white light for 6 days.

(Wang et al., 2014)

cm¹ is a complex modifier of the eye phenotype caused by expression of bchs^EP2299 under the control of Scer\GAL4^GMR.PF.

(Simonsen et al., 2007)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (2)

Holtzman, S. and Kaufman, T. (2013)

Mutant

Wild-type