FlyBase Allele Report: Dmel\cta[5]

General Information

Symbol

Dmel\cta⁵

Species

D. melanogaster

Name

FlyBase ID

FBal0002121

Feature type

allele

Associated gene

Dmel\cta

Associated Insertion(s)

Carried in Construct

Also Known As

cta^RC10

Key Links

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Morize et al., 1998)

Mutagen

ethyl methanesulfonate

(Parks and Wieschaus, 1991, Schupbach and Wieschaus, 1989)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

amnioproctodeal invagination

(Sweeton et al., 1991)

cephalopharyngeal skeleton | maternal effect

(Schupbach and Wieschaus, 1989)

ectoderm

(Kerridge et al., 2016)

egg chamber

(Magie et al., 1999)

embryo | extended germ band stage | maternal effect

(Schupbach and Wieschaus, 1989)

embryonic/first instar larval cuticle | maternal effect

(Schupbach and Wieschaus, 1989)

embryonic epidermis | ventral

(Parks and Wieschaus, 1991, Sweeton et al., 1991)

gonad

(Warrior, 1994)

larval segmental nerve branch SNa of A1-7

(Ratnaparkhi and Zinn, 2007)

mesoderm

(Kerridge et al., 2016)

nurse cell ring canal

(Magie et al., 1999)

posterior endoderm | maternal effect

(Schupbach and Wieschaus, 1989)

posterior fused midgut primordium

(Kerridge et al., 2016)

posterior midgut primordium | maternal effect

(Schupbach and Wieschaus, 1989)

ventral furrow

(Parks and Wieschaus, 1991)

ventral furrow | maternal effect (with Df(2L)C')

(Fox and Peifer, 2007)

Detailed Description

Statement

Reference

Mesoderm invagination is delayed (mesoderm breadth is significantly reduced), posterior midgut is variably affected (the anterior movement of pole cells due to posterior midgut invagination and tissue extension is defective) and ectoderm extension is significantly reduced in cta⁵/cta⁵ embryos compared to controls.

(Kerridge et al., 2016)

The ab1a, ab2A, ab3A and ab1C olfactory receptor neurons respond normally to broad concentrations of odorants and CO[[2]].

(Yao and Carlson, 2010)

Embryos derived from cta⁵/Df(2L)C' females show defects in cell constriction during ventral furrow formation; constricted cells are seen next to unconstricted cells and mesodermal cells internalise at varying angles and show abnormal morphology after internalisation.

(Fox and Peifer, 2007)

cta⁵ mutants exhibit SNa motor axons phenotypes in 44% of hemisegments.

(Ratnaparkhi and Zinn, 2007)

The mitotic pattern in early mutant embryos shows the same delay in the ventral domain as in wild-type embryos.

(Großhans and Wieschaus, 2000)

Egg chambers of mutant homozygotes show mild actin cytoskeleton defects.

(Magie et al., 1999)

Heat induced ectopic expression of fog^hs.PM has no morphological consequences. cta^Germ.Q303R, cta^Germ.R277H or cta^Germ.R277H can rescue the female sterility of mutants, few of the eggs survive to adulthood.

(Morize et al., 1998)

Defective in gonad assembly.

(Warrior, 1994)

Embryos fail to undergo normal gastrulation: central region of ventral zone fails to undergo rapid transition to a groove. Ventral furrow remains open, embryos do not constrict enough to form shallow cup in which the pole cells sit so they remain on the outside.

(Parks and Wieschaus, 1991)

Cellular blastoderm and gastrulation initiation are normal. Normal expression of twi, suggesting no abnormalities in dorsal-ventral patterning. Rapid phase of constriction is absent: many cells in midventral domain never constrict and many of the lateral twi expressing cells do not invaginate. No invagination of the posterior midgut.

(Sweeton et al., 1991)

Eggs derived from homozygous females cellularise normally but become abnormal at gastrulation; the posterior midgut is missing and no advancement of the germband around the posterior pole is seen. Extensive folding of the germ band is seen along the ventral side of the egg. This phenotype resembles that of fog mutants. The anterior midgut appears to form normally. The cuticle has holes at the anterior and posterior ends and there are frequent defects in the head skeleton, although the thoracic and abdominal segments appear fairly normal.

(Schupbach and Wieschaus, 1989)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

cta⁵/cta[+] is an enhancer of visible phenotype of RhoGEF2^PX10/RhoGEF2^4.1

(Nikolaidou and Barrett, 2004)

cta⁵/cta[+] is an enhancer of partially lethal phenotype of RhoGEF2^PX10/RhoGEF2^4.1

(Nikolaidou and Barrett, 2004)

cta⁵/cta[+] is an enhancer of visible phenotype of RhoGEF2^PX6/RhoGEF2^4.1

(Nikolaidou and Barrett, 2004)

cta⁵/cta[+] is an enhancer of partially lethal phenotype of RhoGEF2^PX6/RhoGEF2^4.1

(Nikolaidou and Barrett, 2004)

Phenotype Manifest In

Enhancer of

Statement

Reference

cta⁵/cta[+] is an enhancer of wing phenotype of RhoGEF2^PX10/RhoGEF2^4.1

(Nikolaidou and Barrett, 2004)

cta⁵/cta[+] is an enhancer of wing phenotype of RhoGEF2^PX6/RhoGEF2^4.1

(Nikolaidou and Barrett, 2004)

cta⁵ is an enhancer of phenotype of Rho1^rev220

(Magie et al., 1999)

Suppressor of

Statement

Reference

cta⁵/cta[+] is a suppressor of wing phenotype of Scer\GAL4^Bx-MS1096, fog^UAS.cRa

(Ratnaparkhi, 2013)

cta⁵/cta[+] is a suppressor of wing | male limited phenotype of Scer\GAL4^Bx-MS1096, fog^UAS.cRa

(Ratnaparkhi, 2013)

Other

Statement

Reference

Abl⁴, cta⁵/Df(2L)C' has ventral midline of embryo | maternal effect phenotype

(Fox and Peifer, 2007)

Additional Comments

Genetic Interactions

Statement

Reference

The presence of cta⁵ strongly suppresses the wing defects seen in male flies expressing fog^Scer\UAS.cRa under the control of Scer\GAL4^Bx-MS1096.

(Ratnaparkhi, 2013)

Mesoderm remains on the surface and the midline cells do not join in double mutant embryos derived from cta⁵/Df(2L)C' ; Abl⁴/Abl⁴ females. These phenotypes are not seen in either single mutant.

(Fox and Peifer, 2007)

RhoGEF2^PX6/cta⁵ RhoGEF2^4.1 animals show 8% adult viability. The frequency of wing defects in these animals is 92% (compared to 70% in RhoGEF2^PX6/RhoGEF2^4.1 adults). RhoGEF2^PX10/cta⁵ RhoGEF2^4.1 animals show 28% adult viability. The frequency of wing defects in these animals is 35% (compared to 4% in RhoGEF2^PX10/RhoGEF2^4.1 adults).

(Nikolaidou and Barrett, 2004)

Egg chambers transheterozygous for Rho1^rev220 and cta mutants show disruptions of the ovarian cytoskeleton and ring canals similar to that seen in females heterozygous for Rho1^rev220 and RpII140^wimp.

(Magie et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

cta⁵ is rescued by cta^Germ.R277C

(Morize et al., 1998)

cta⁵ is rescued by cta^Germ.R277H

(Morize et al., 1998)

cta⁵ is rescued by cta^Germ.Q303R

(Morize et al., 1998)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

concertina^RC10

(Yao and Carlson, 2010)

cta⁵

cta^RC10

(Bailles et al., 2019, Kerridge et al., 2016, Fuse et al., 2013, Kanesaki et al., 2013, Ratnaparkhi, 2013, Fox and Peifer, 2007, Ratnaparkhi and Zinn, 2007, Nikolaidou and Barrett, 2004, Großhans and Wieschaus, 2000, Magie et al., 1999, Morize et al., 1998, Costa et al., 1994, Warrior, 1994, Parks and Wieschaus, 1991, Sweeton et al., 1991)

cta^RC

Name Synonyms

concertina RC10

(Fuse et al., 2003)

Secondary FlyBase IDs

References (18)

Report Sections

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