FlyBase Allele Report: Dmel\da[3]

General Information

Symbol

Dmel\da³

Species

D. melanogaster

Name

FlyBase ID

FBal0002216

Feature type

allele

Associated gene

Dmel\da

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Progenitor genotype

Cytology

Description

normal Southern

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

Phenotype Manifest In

dorsal row of wing sensilla | somatic clone

(Jafar-Nejad et al., 2006)

intestinal stem cell | somatic clone

(Bardin et al., 2010)

trichome of the posterior wing margin | somatic clone

(Jafar-Nejad et al., 2006)

ventral row of wing sensilla | somatic clone

(Jafar-Nejad et al., 2006)

Detailed Description

Statement

Reference

Homozygous intestinal stem cell clones fail to grow and are composed of single or pairs of differentiated enterocyte cells.

(Bardin et al., 2010)

da³ clones in the wing result in the loss of both anterior and posterior wing margin bristles.

(Jafar-Nejad et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Sxl[+]/Sxl^fP7B0, da³ has abnormal sex-determination phenotype, enhanceable by fl(2)d^unspecified/fl(2)d^unspecified

(Kan et al., 2017)

Sxl[+]/Sxl^fP7B0, da³ has abnormal sex-determination phenotype, enhanceable by Mettl14^SK1/Mettl14[+]

(Kan et al., 2017)

Sxl[+]/Sxl^fP7B0, da³ has abnormal sex-determination phenotype, enhanceable by Ythdc1[+]/Ythdc1^NP1

(Kan et al., 2017)

Sxl[+]/Sxl^fP7B0, da³ has abnormal sex-determination phenotype, enhanceable by Ythdc1^NP3/Ythdc1[+]

(Kan et al., 2017)

Sxl[+]/Sxl^fP7B0, da³ has abnormal sex-determination phenotype, enhanceable by Ythdf^NP3/Ythdf[+]

(Kan et al., 2017)

NOT Enhanced by

Statement

Reference

Sxl[+]/Sxl^fP7B0, da³ has abnormal sex-determination phenotype, non-enhanceable by Ythdf^NP1/Ythdf[+]

(Kan et al., 2017)

Sxl[+]/Sxl^fP7B0, da³ has abnormal sex-determination phenotype, non-enhanceable by Ythdf^NP2/Ythdf[+]

(Kan et al., 2017)

Suppressor of

Statement

Reference

da³ is a suppressor of lethal | somatic clone phenotype of emc^AP6

(Bhattacharya and Baker, 2011)

Other

Statement

Reference

Sxl[+]/Sxl^fP7B0, da³ has abnormal sex-determination phenotype

(Kan et al., 2017)

Phenotype Manifest In

Enhancer of

Statement

Reference

da[+]/da³ is an enhancer of interommatidial bristle | cold sensitive phenotype of wg^ts.sev

(Cadigan et al., 2002)

Suppressor of

Statement

Reference

da³ is a suppressor of eye disc | somatic clone phenotype of emc^AP6

(Bhattacharya and Baker, 2011)

da³ is a suppressor of eye disc morphogenetic furrow | somatic clone phenotype of emc^AP6

(Bhattacharya and Baker, 2011)

da³ is a suppressor of eye disc anterior to the morphogenetic furrow | somatic clone phenotype of emc^AP6

(Bhattacharya and Baker, 2011)

Other

Statement

Reference

Scer\GAL4^Tub.PU, da³, sens^UAS.cNa has eo neuron | somatic clone phenotype

(Jafar-Nejad et al., 2006)

Scer\GAL4^Tub.PU, da³, sens^UAS.cNa has adult thorax & microchaeta | somatic clone phenotype

(Jafar-Nejad et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

The progeny from da³ heterozygotes females and Sxl^fP7B0 males show a decreased female:male ratio as compared to the progeny from controls.

(Kan et al., 2017)

da³/emc^AP6 double mutant eye disc clones survive in a non-minute background but lack neuronal differentiation. Neither ectopic neuronal differentiation ahead of the furrow nor ectopic morphogenetic furrow initiation from the eye margins is observed.

(Bhattacharya and Baker, 2011)

Thoracic clones that express sens^Scer\UAS.cNa, under the control of Scer\GAL4^tub, in a da³ background results in clones that lack microchaetae. No neurons are observed in these clones.

(Jafar-Nejad et al., 2006)

da³ dominantly enhances the loss of eye bristles seen in flies carrying wg^ts.sev at 17.6^oC.

(Cadigan et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

da¹

Rescued by

da³ is rescued by da^+t8.8

(Bhattacharya and Baker, 2011)

Comments

Fails to complement deficiencies for da and other lethal da alleles.

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

da³

(Li and Baker, 2019, Li and Baker, 2018, Bhattacharya and Baker, 2011, Bardin et al., 2010, Jafar-Nejad et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

Open Close