FlyBase Allele Report: Dmel\Dfd[12]

General Information

Symbol

Dmel\Dfd¹²

Species

D. melanogaster

Name

FlyBase ID

FBal0002385

Feature type

allele

Associated gene

Dmel\Dfd

Associated Insertion(s)

Carried in Construct

Also Known As

Dfd^r11, EbR11, Dfd^rR11

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Zeng et al., 1994)

hypomorphic allele - genetic evidence

(Merrill et al., 1987)

Mutagen

ethyl methanesulfonate

(Pattatucci et al., 1991, Lewis et al., 1980, Lewis et al., 1980)

Progenitor genotype

Cytology

Polytene chromosomes normal.

(Pattatucci et al., 1991)

Description

Amino acid replacement: Y210term.

(Zeng et al., 1994)

Nucleotide substitution: T?A.

(Zeng et al., 1994)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:6,792,954..6,792,954 [+]

Nucleotide change:

T6792954A

Reported nucleotide change:

T?A

Amino acid change:

Y210term | Dfd-PA

Reported amino acid change:

Y210term

(Zeng et al., 1994)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

cirri

(Brown et al., 1999)

embryonic mandibular segment (with Dfd¹⁶)

(Hueber et al., 2007, Lohmann et al., 2002)

embryonic maxillary segment (with Dfd¹⁶)

(Hueber et al., 2007, Lohmann et al., 2002)

mouth hook

(Brown et al., 1999)

Detailed Description

Statement

Reference

Stage 12 Dfd¹⁶/Dfd¹² embryos show displacement of the maxillary segment and mandibular segments due to an accumulation of supernumerary cells at the ventral side of both segments. Cells in the ventral part of the maxillary segment are elongated, instead of round like wild-type cells.

(Hueber et al., 2007)

In Dfd¹²/Dfd¹⁶ embryos, the maxillary cirri primordium and the anterior boundary of the dorsal ridge, between the mandibular and maxillary segments, are missing. The number of apoptotic cells in the maxillary segment is reduced when compared to wild-type.

(Lohmann et al., 2002)

Dfd¹²/Df(3R)Scr embryos lack the mouthhooks and cirri, while the more posterior mouthparts are unaffected. The mouthhook and cirri defects are rescued in Dfd¹²/Df(3R)Scr embryos expressing Dfd^Scer\UAS.cBa under the control of Scer\GAL4^69B. Head involution fails in these animals and the posterior mouthparts fail to form. Dfd¹²/Dfd¹⁶ embryos lack the mouthhooks and cirri, while the more posterior mouthparts are unaffected.

(Brown et al., 1999)

Mouth hook material is in a position posterior to wild type and rarely possess maxillary cirri: defects in structures derived from the maxillary, mandibular and premandibular regions of the embryonic head. Mitotic recombination analysis suggests that in the adult Dfd affects the head structures homologous to those of the embryo.

(Merrill et al., 1987)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

Dfd¹²/Dfd¹⁶ has mouth hook phenotype, suppressible by Tcas\Dfd^UAS.cBa/Scer\GAL4^69B

(Brown et al., 1999)

Dfd¹²/Dfd¹⁶ has cirri phenotype, suppressible by Tcas\Dfd^UAS.cBa/Scer\GAL4^69B

(Brown et al., 1999)

Dfd¹²/Dfd¹⁶ has cephalopharyngeal skeleton | posterior phenotype, suppressible by Tcas\Dfd^UAS.cBa/Scer\GAL4^69B

(Brown et al., 1999)

Dfd¹²/Dfd¹⁶ has embryonic head phenotype, suppressible by Tcas\Dfd^UAS.cBa/Scer\GAL4^69B

(Brown et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The mouthhook and cirri defects are rescued in Dfd¹²/Dfd¹⁶ embryos expressing Tcas\Dfd^Scer\UAS.cBa under the control of Scer\GAL4^69B. Head involution fails in these animals and the posterior mouthparts fail to form.

(Brown et al., 1999)

Complementation and Rescue Data

Partially rescued by

Dfd¹²/Df(3R)Scr is partially rescued by Dfd^UAS.cBa/Scer\GAL4^69B

(Brown et al., 1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

2315

Ki¹ Dfd¹² rn^roe-1 p^p/TM3, Sb¹

Notes on Origin

Discoverer

R. Lewis.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Dfd¹²

(Becker et al., 2016, Kuert et al., 2014)

Dfd¹

(Pattatucci et al., 1991)

Dfd^r11

(Stöbe et al., 2009, Hueber et al., 2007, Lohmann et al., 2002, Hirth et al., 1998, Chan et al., 1997)

Dfd^rR11

(Zeng et al., 1994, Pattatucci et al., 1991, Merrill et al., 1987)

EbR11

(Denell, 1994, Lewis et al., 1980, Lewis et al., 1980)

Name Synonyms

Secondary FlyBase IDs

References (14)

Report Sections

Open Close