FlyBase Allele Report: Dmel\dlg1[18]

General Information

Symbol

Dmel\dlg1¹⁸

Species

D. melanogaster

Name

FlyBase ID

FBal0002687

Feature type

allele

Associated gene

Dmel\dlg1

Associated Insertion(s)

Carried in Construct

Also Known As

dlg^1P20

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Le Borgne and Schweisguth, 2003)

Mutagen

ethyl methanesulfonate

(Woods and Bryant, 1989)

Progenitor genotype

Cytology

Description

A nonsense mutation that results in the truncation of the GK domain in the expressed protein.

(Siegrist and Doe, 2005)

Amino acid replacement: Q?term.

(Woods et al., 1996)

The premature stop codon is predicted to eliminate the last thirds of the GUK domain without affecting the conserved putative GMP-binding residues.

(Woods et al., 1996)

Nucleotide substitution: C2752T.

(Woods et al., 1996)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

X:11,405,971..11,405,971 [+]

Nucleotide change:

C11405971T

Reported nucleotide change:

C2752T

Amino acid change:

Reported amino acid change:

Q?term

Comment:

Stop codon is predicted to eliminate the last thirds of the GUK domain without affecting the conserved putative GMP-binding residues.

(Woods et al., 1996)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

antenna

(Woods et al., 1996)

border follicle cell | temperature conditional (with dlg1²)

(Goode and Perrimon, 1997)

external sensory organ precursor cell I

(Bellaiche et al., 2001)

interommatidial bristle

(Woods et al., 1996)

leg

(Woods et al., 1996)

macrochaeta

(Woods et al., 1996)

Detailed Description

Statement

Reference

In mutant pI cells the onset of spindle rotation is delayed. Unlike the wild-type, rotation is observed in late metaphase.

(Bellaiche et al., 2001)

Follicle cells have an invasive phenotype, intermingling with germ cells in the egg chamber in dlg1²/dlg1¹⁸ females. Nurse cells extend processes to meet the invasive follicle cells.

(Goode and Perrimon, 1997)

Pharate adults exhibit severe bristle defects, antenna and legs have small overgrowth regions, eyes show defects in the planar polarity of the ommatidial bristles.

(Woods et al., 1996)

The lethal period is during the late pupal phase.

(Woods and Bryant, 1989)

late pupal lethal

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

dlg1[+]/dlg1¹⁸ is a non-enhancer of ommatidium phenotype of Vang^stbm-153

(Courbard et al., 2009)

NOT Suppressor of

Statement

Reference

dlg1[+]/dlg1¹⁸ is a non-suppressor of ommatidium phenotype of Vang^stbm-153

(Courbard et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

Heterozygosity for dlg1¹⁸ has no effect on the frequency of ommatidia that show planar cell polarity defects in Vang^stbm-153 homozygotes.

(Courbard et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially complements

dlg1¹²

(Woods et al., 1996)

Fails to complement

dlg1¹⁴

(Goode and Perrimon, 1997)

dlg1⁷

(Goode and Perrimon, 1997)

dlg1⁶

(Goode and Perrimon, 1997)

dlg1⁵

(Goode and Perrimon, 1997)

dlg1¹⁵

(Woods et al., 1996)

dlg1¹⁴

(Woods et al., 1996)

dlg1⁷

(Woods et al., 1996)

dlg1⁶

(Woods et al., 1996)

Comments

complements dlg1² and dlg1¹³.

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

36279

y¹ dlg1¹⁸/FM7a

Notes on Origin

Discoverer

Perrimon.

Comments

Class III mutation.

(Woods et al., 1996)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

1P20

(Woods and Bryant, 1989)

Dlg^1P20

(Neville et al., 2023)

dlg1¹⁸

dlg¹⁸

(Bergstralh et al., 2016)

dlg^1P20

(Khoury and Bilder, 2020, Emery et al., 2005, Langevin et al., 2005, Siegrist and Doe, 2005, Le Borgne and Schweisguth, 2003, Bellaiche et al., 2001, Thomas et al., 2000, Goode and Perrimon, 1997, Tejedor et al., 1997, Woods et al., 1996)

dlg^IP20

(Courbard et al., 2009)

dlg^ip20

(Goode, 2000)

l(1)1P20

l(1)d.lg-1^1P20

(Gateff and Mechler, 1989)

Name Synonyms

Secondary FlyBase IDs

References (17)

Report Sections

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