FB2024_03 , released June 25, 2024
Allele: Dmel\E(z)28
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General Information
Symbol
Dmel\E(z)28
Species
D. melanogaster
Name
FlyBase ID
FBal0003407
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Nature of the Allele
Progenitor genotype
Cytology
Description

Amino acid replacement: C363Y. Nucleotide substitution: G1191A. Mutation in the middle portion of the protein.

Point mutation.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Nucleotide change:

G10636021A

Reported nucleotide change:

G1191A

Amino acid change:

C363Y | E(z)-PA; C363Y | E(z)-PB; C368Y | E(z)-PC

Reported amino acid change:

C363Y

Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous males raised at 20oC have reduced viability (51% compared to wild-type) and a slight increase in the number of sex combs, usually having sex comb teeth on one or both second legs. Homozygous males raised at 24oC have lower viability (43% compared to wild-type), always have sex comb teeth on both second legs, and usually have sex comb teeth on one or both third legs. Homozygous males raised at 27oC do not survive to adulthood, but pharate adults have sex comb teeth on all legs. E(z)5/E(z)28 males have lower viability and higher numbers of sex combs than E(z)28 homozygotes at all temperatures. The fecundity of homozygous females drops during exposure to the restrictive temperature of 29oC. Ovaries from females maintained at the restrictive temperature for 5 days have degenerating nurse cells in egg chambers beyond stage 3-4. The viability of eggs laid by females maintained at 29oC drops to less than 10% within 1 day of the temperature shift.

Heat sensitive allele. Dominant suppressor of z mutants.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressor of
Statement
Reference

E(z)28 is a suppressor of phenotype of z1

Additional Comments
Genetic Interactions
Statement
Reference

E(z)28/+ does not impair cytotype-mediated repression of P-element excision.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
l(3)OX736
pcoox736
Name Synonyms
Secondary FlyBase IDs
    References (9)