FlyBase Allele Report: Dmel\exu[4]

General Information

Symbol

Dmel\exu⁴

Species

D. melanogaster

Name

FlyBase ID

FBal0003918

Feature type

allele

Associated gene

Dmel\exu

Associated Insertion(s)

Carried in Construct

Also Known As

exu^SC, exu^SC02, exu^Sco2

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Crowley and Hazelrigg, 1995)

Mutagen

ethyl methanesulfonate

(Schupbach and Wieschaus, 1989, Tearle and Nusslein-Volhard, 1987)

Progenitor genotype

Cytology

Description

Novel termination codon within the coding region.

(MacDonald et al., 1991)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:20,670,125..20,670,125 [-]

Nucleotide change:

C20670125T

Reported nucleotide change:

C1021T

Amino acid change:

Q53term | exu-PA; Q53term | exu-PB; Q53term | exu-PC; Q53term | exu-PD

Reported amino acid change:

Q53term

(MacDonald et al., 1991)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

cephalic furrow | maternal effect

(Schupbach and Wieschaus, 1989)

embryonic/first instar larval cuticle | anterior | maternal effect

(Schupbach and Wieschaus, 1989)

embryonic head (with exu^VL)

(Irion et al., 2006)

Detailed Description

Statement

Reference

exu^VL/exu⁴ embryos lack anterior head structures.

(Irion et al., 2006)

P{S200-exu} can rescue the maternal effect lethality.

(MacDonald et al., 1991)

Eggs derived from homozygous females cellularise normally but become abnormal at gastrulation; the cephalic furrow is shifted forward and the anterior most cells form an inverted posterior end, forming a posterior midgut, proctodeal region and often Malpighian tubules. Anterior head structures of the cuticle are missing.

(Schupbach and Wieschaus, 1989)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

exu⁴ has lethal | recessive | maternal effect phenotype, suppressible by exu::Dpse\exu1⁵⁹⁴

(Luk et al., 1994)

Suppressor of

Statement

Reference

exu^VL/exu⁴ is a suppressor of visible | homeotic phenotype of mira^{Δ103.αTub67C.mGFP6}

(Irion et al., 2006)

Phenotype Manifest In

Suppressor of

Statement

Reference

exu^VL/exu⁴ is a suppressor of embryonic abdomen | ectopic phenotype of mira^{Δ103.αTub67C.mGFP6}

(Irion et al., 2006)

exu^VL/exu⁴ is a suppressor of embryonic thorax phenotype of mira^{Δ103.αTub67C.mGFP6}

(Irion et al., 2006)

Other

Statement

Reference

exu^VL/exu⁴, mira^{Δ103.αTub67C.mGFP6} has embryonic head phenotype

(Irion et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

Females that express mira^{Δ103.αTub67C.T:Avic\GFP-m6} in a exu^VL/exu⁴ background produce embryos with an exu phenotype, in which the thorax and abdomen develop normally, but the head is absent.

(Irion et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

exu⁴ is rescued by exu^HH

(Crowley and Hazelrigg, 1995)

exu⁴ is rescued by exu^+t7.4

(MacDonald et al., 1991)

Partially rescued by

exu⁴ is partially rescued by exu^HN

(Crowley and Hazelrigg, 1995)

Comments

A single P{exu^HH} insertion rescues both male and female sterility. exu^HN rescues female but not male sterility.

(Crowley and Hazelrigg, 1995)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

34512

cn¹ exu⁴ bw¹/CyO, l(2)DTS100¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

exu⁴

(Fingerhut et al., 2019)

exu^SC02

(Pokrywka and Stephenson, 1995, Pokrywka and Stephenson, 1994, Marcey et al., 1991)

exu^SC

(Irion and St Johnston, 2007, Irion and St Johnston, 2007, Irion et al., 2006, Cha et al., 2001, MacDonald et al., 1991, Tearle and Nusslein-Volhard, 1987)

exu^Sco2

(Cha et al., 2001, Crowley and Hazelrigg, 1995)

Name Synonyms

Secondary FlyBase IDs

References (14)

Report Sections

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