FB2024_03 , released June 25, 2024
Allele: Dmel\haync2rv3
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General Information
Symbol
Dmel\haync2rv3
Species
D. melanogaster
Name
FlyBase ID
FBal0005387
Feature type
allele
Associated gene
Dmel\hay
Associated Insertion(s)
Carried in Construct
Also Known As
hayrv3
Key Links
Genomic Maps

Allele class

antimorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

antimorphic allele - genetic evidence

(Regan and Fuller, 1990)
Mutagen
ethyl methanesulfonate
(Regan and Fuller, 1990)
Progenitor genotype
haync2
(Mounkes and Fuller, 1999, Regan and Fuller, 1990)
Cytology
Description

Mutation lies in conserved nucleotide-binding domain.

(Mounkes and Fuller, 1999)

Nucleotide substitution: C?T.

(Mounkes and Fuller, 1999)

Amino acid replacement: R380term.

(Mounkes and Fuller, 1999)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:10,632,587..10,632,587 [+]
Nucleotide change:

C10632587T

Reported nucleotide change:

C?T

Amino acid change:

R374term | hay-PA; R374term | hay-PB

Reported amino acid change:

R380term

Comment:

The amino acid numbering differs between FBrf0108244 and the reference sequence. The positions and nature of the base substitutions in the mutants are derived from the sequence in Fig. 1 and from Table 1, and provide unambiguous assignments.

(Mounkes and Fuller, 1999)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Only small homozygous clones are recovered in the third instar larval eye disc.

      (Matsuno et al., 2007)

      Lethal over deficiency of hay. Heterozygotes exhibit defects in the structure and function of the male meiotic spindle.

      (Regan and Fuller, 1990)

      recessive larval lethal

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      hay[+]/haync2rv3 is an enhancer of increased body size | third instar larval stage phenotype of hfpEP3058

      (Lee et al., 2015)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The large body size characteristic for the hfpEP3058/hfpEP3058 third instar larvae is further increased by combination with haync2rv1 in heterozygous state.

      (Lee et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      HayRV3
      (Lee et al., 2015)
      Haync2rv3
      (Lee et al., 2015)
      haync2rv3
      hayrv3
      (Matsuno et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)