FB2024_03 , released June 25, 2024
Allele: Dmel\kni2
Open Close
General Information
Symbol
Dmel\kni2
Species
D. melanogaster
Name
FlyBase ID
FBal0005772
Feature type
allele
Associated gene
Dmel\kni
Associated Insertion(s)
Carried in Construct
Also Known As
kni7G, kni7G75
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Gerwin et al., 1994)
Mutagen
ethyl methanesulfonate
(Gerwin et al., 1994, Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description

Nucleotide substitution: T2934A. Amino acid replacement: C48S.

(Gerwin et al., 1994)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:20,693,984..20,693,984 [-]
Nucleotide change:

T20693984A

Reported nucleotide change:

T2934A

Amino acid change:

C48S | kni-PA; C53S | kni-PB

Reported amino acid change:

C48S

(Gerwin et al., 1994)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      hb, kni double mutants show reduced rate of germ band extension. Cell intercalation is reduced in the region where the germ band fails to narrow, i.e. the region where eve and other pair-rule gene expression is uniform.

      (Irvine and Wieschaus, 1994)

      Larval phenotype: abdominal segments A1-A7 fused, dominant defects in A2-A5.

      (Carroll and Scott, 1986)

      strong

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      kni2 has phenotype, enhanceable by groE48

      (Payankaulam and Arnosti, 2009)

      kni2 has phenotype, enhanceable by gro1

      (Payankaulam and Arnosti, 2009)
      Enhancer of
      Statement
      Reference

      kni2 is an enhancer of phenotype of groE48

      (Payankaulam and Arnosti, 2009)

      kni2 is an enhancer of phenotype of gro1

      (Payankaulam and Arnosti, 2009)
      NOT Enhancer of
      Statement
      Reference

      kni2 is a non-enhancer of embryo | dorsal closure stage phenotype of kay1/kay2

      (Gritzan et al., 2002)

      kni2 is a non-enhancer of wing vein | ectopic phenotype of Scer\GAL432B, rlSem.C.UAS

      (Gritzan et al., 2002)
      NOT Suppressor of
      Statement
      Reference

      kni2 is a non-suppressor of embryo | dorsal closure stage phenotype of kay1/kay2

      (Gritzan et al., 2002)

      kni2 is a non-suppressor of wing vein | ectopic phenotype of Scer\GAL432B, rlSem.C.UAS

      (Gritzan et al., 2002)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      References (7)