FB2024_03 , released June 25, 2024
Allele: Dmel\scra03427
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General Information
Symbol
Dmel\scra03427
Species
D. melanogaster
Name
FlyBase ID
FBal0008026
Feature type
allele
Associated gene
Dmel\scra
Associated Insertion(s)
P{PZ}scra03427
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Doberstein et al., 1997)
Progenitor genotype
Associated Insertion(s)
P{PZ}scra03427
Cytology
Description

A P-element is inserted 53bp upstream of a potential scra start codon.

(Field et al., 2005)

P{PZ} insertion in the 5' end of scra.

(Doberstein et al., 1997)
Allele components
Component
Use(s)
Inserted element
P{PZ}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Spermatids in homozygous male germline clones are multinucleate, indicating a defect in male meiotic cytokinesis. In addition, the mitochondrial derivatives are enlarged in the mutant spermatids.

      (Goldbach et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      scrak09008a

      (BDGP Project Members, 1994-1999)
      Rescued by

      scra03427 is rescued by scraβTub85D.mRFP1

      (Goldbach et al., 2010)
      Comments

      The cytokinesis defect of scra03427 homozygous clones in the male germline is completely rescued by scraβTub85D.T:Disc\RFP-mRFP.

      (Goldbach et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      A. Spradling.

      Comments
      Comments

      Based on adult viability, and common cellularisation defects, the following scra alleles can be ranked from strongest to weakest as follows: scra7 = scra8 > scra03427 > scra5 = scra4 > scra1 > scra3 = scra6 = scraB26-35 = scraC82-45.

      (Field et al., 2005)

      Complements: Cyt-b501857. Complements: Rpt105643. Complements: l(2)0849208492. Complements: l(2)k00107k00107. Complements: hrgk07619. Complements: l(2)08492k10320. Complements: Rpt1k11110.

      (BDGP Project Members, 1994-1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      P3427
      (Field et al., 2005)
      anilPZ
      (Goldbach et al., 2010)
      l(2)03427
      (Spradling et al., 1999)
      l(2)0342703427
      scra03427
      (Kahsai and Cook, 2018, Rudrapatna et al., 2014)
      scrapsP3427
      (Doberstein et al., 1997)
      Name Synonyms
      Secondary FlyBase IDs
        References (9)