FlyBase Allele Report: Dmel\Sec61β[07214]

General Information

Symbol

Dmel\Sec61β⁰⁷²¹⁴

Species

D. melanogaster

Name

FlyBase ID

FBal0008128

Feature type

allele

Associated gene

Dmel\Sec61β

Associated Insertion(s)

P{PZ}Sec61β⁰⁷²¹⁴

Carried in Construct

Also Known As

l(2)07214

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

Progenitor genotype

Associated Insertion(s)

P{PZ}Sec61β⁰⁷²¹⁴

Cytology

Description

P{PZ} insertion upstream of the putative transcription start site.

(Valcarcel et al., 1999)

Allele components

Component

Use(s)

Inserted element

P{PZ}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Huntington's disease

modeled by Hsap\HTT^NT.128Q.UAS

(Lu et al., 2013)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | pupal stage | recessive

(Perrimon et al., 1996)

lethal | recessive

(Spradling et al., 1999, Valcarcel et al., 1999)

some die during embryonic stage | rescuable maternal effect

(Perrimon et al., 1996)

Phenotype Manifest In

abdomen | germline clone | posterior

(Perrimon et al., 1996)

embryonic/first instar larval cuticle

(Valcarcel et al., 1999)

embryonic/first instar larval cuticle | germline clone

(Valcarcel et al., 1999, Perrimon et al., 1996)

head | germline clone

(Perrimon et al., 1996)

leg

(Valcarcel et al., 1999)

Detailed Description

Statement

Reference

Homozygous embryos have similar cuticle defects to Sec61β¹⁴⁴⁴⁸ homozygotes. Embryos derived from homozygous germ-line clones show poor cuticle development. Sec61β⁰⁷²¹⁴/Sec61β^k07836 escapers show defects in leg development.

(Valcarcel et al., 1999)

Germline clones produce eggs with poor cuticle development. Paternally rescued eggs exhibit head and tail defects.

(Perrimon et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Sec61β⁰⁷²¹⁴, Scer\GAL4^elav-C155 is an enhancer of abnormal locomotor behavior phenotype of Hsap\HTT^NT.128Q.UAS, Scer\GAL4^elav-C155

(Lu et al., 2013)

Suppressor of

Statement

Reference

Sec61beta[+]/Sec61β⁰⁷²¹⁴ is a suppressor of visible | heat sensitive phenotype of peb¹

(Wilk et al., 2004)

Phenotype Manifest In

Suppressor of

Statement

Reference

Sec61beta[+]/Sec61β⁰⁷²¹⁴ is a suppressor of eye | heat sensitive phenotype of peb¹

(Wilk et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

The frequency of leg-to-wing transdetermination caused by expression of wg^Act5C.PS in clones during the mid-second larval instar is dominantly suppressed by Sec61β⁰⁷²¹⁴.

(McClure and Schubiger, 2008)

Xenogenetic Interactions

Statement

Reference

Co-expression of Sec61β⁰⁷²¹⁴ with Hsap\HTT^{NT.128Q.Scer\UAS} in the nervous system, under the control of Scer\GAL4^elav-C155 enhances the motor performance defects found upon expression of Hsap\HTT^{NT.128Q.Scer\UAS} alone.

(Lu et al., 2013)

Complementation and Rescue Data

Fails to complement

Sec61β¹⁴⁴⁴⁸

(Valcarcel et al., 1999)

Sec61β^k03307

(BDGP Project Members, 1994-1999)

Sec61β^k07836

(BDGP Project Members, 1994-1999)

Rescued by

Sec61β⁰⁷²¹⁴ is rescued by Sec61β^Tub.PV

(Valcarcel et al., 1999)

Comments

Lethality is rescued by Sec61β^Tub.PV.

(Valcarcel et al., 1999)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

12339

P{PZ}Sec61β⁰⁷²¹⁴ cn¹/CyO; ry⁵⁰⁶

Notes on Origin

Discoverer

A. Spradling.

Comments

Complements: ttv^00681b. Complements: ttv⁰¹⁹⁰¹. Complements: Tfb1⁰⁶⁹⁴⁹. Complements: Tfb1⁰⁶⁹⁵⁰. Complements: Rpn6^k00103. Complements: ttv^k00115. Complements: ttv^k00812. Complements: ttv^k01106. Complements: ttv^k03617. Complements: ttv^k06619. Complements: ttv^k11904.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

BL-12339

(Rollmann et al., 2007)

DSec61β^P2

(Valcarcel et al., 1999)

Sec1^β07214

(Bischoff et al., 2009)

Sec61⁰⁷²¹⁴

(Wilk et al., 2004)

Sec61β⁰⁷²¹⁴

Secβ61⁰⁷²¹⁴

(McClure and Schubiger, 2008)

l(2)07214

(Shaffer et al., 2002, Spradling et al., 1999, Valcarcel et al., 1999)

l(2)07214⁰⁷²¹⁴

(Perrimon et al., 1996, BDGP Project Members, 1994-1999)

Name Synonyms

Secondary FlyBase IDs

References (12)

Report Sections

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