Nucleotide substitution: G4418A.
Amino acid replacement: W1266term.
G5359737A
G4418A
W1266term | nompC-PD; W1266term | nompC-PE; W1266term | nompC-PF; W1266term | nompC-PG; W1266term | nompC-PH
W1266term
G to A nucleotide change at the second or third position of the wild type Trp codon leads to a nonsense mutation (exact site of mutation unspecified). The mutation was annotated at the second base of the codon.
Most homozygotes die at the third instar stage.
Crawling speed of homozygous larvae is reduced compared to controls.
Mutant larvae exhibit a almost completely abolished touch response.
In wild-type animals, the antennal receiver moves in a non-linear fashion in response to sound. In the absence of sound the receiver oscillates spontaneously. In mutant animals the nonlinearity of the receiver is markedly reduced. The power of spontaneous oscillations is four times less than in controls. Instead of the single resonance observed in responses to sound, the spontaneous oscillations display several broad peaks.
Flies show severe uncoordination. Mechanoreceptor currents are reduced to 10% of normal. Action potentials are almost completely abolished.
Due to a naming clash that goes back many years, two different alleles of nompC, with contrasting molecular lesions, were named nompC[2]. Thanks to user input, we have been able to disambiguate these two alleles. They are now called nompC[2] and nompC[a9]. The nompC[2] allele was generated in the Zuker lab by EMS (FBrf0127378). The nompC[a1] allele was made by Szidonya and Reuter (FBrf0047784) and published in 1988 as jf24[a1]. Allele jf24[a9] was renamed in Lindsley and Zimm 1992 (p. 353) as l(2)25Dc[2]. Allele l(2)25Dc[2] subsequently became nompC[2] based on a foot note in Kernan et al., 1994 (FBrf0073546) identifying l(2)25Dc as nompC. The references and data for jf24[a9]/l(2)25Dc[2]/nompC[2] have now been split from the nompC[2] FlyBase record and are associated with allele nompC[a9].