FlyBase Allele Report: Dmel\not[02069]

(Weake et al., 2008, Poeck et al., 2001, Salecker, 2001.3.5, Spradling et al., 1999, Martin et al., 1995, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Weake et al., 2008)

enhancer of variegation | dominant

(Zhao et al., 2008)

lethal | recessive

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

lethal - all die before end of pupal stage | recessive

(Poeck et al., 2001, Martin et al., 1995)

some die during pupal stage | recessive

(Poeck et al., 2001, Martin et al., 1995)

Phenotype Manifest In

axon & photoreceptor cell R2

(Weake et al., 2008)

axon & photoreceptor cell R3

(Weake et al., 2008)

axon & photoreceptor cell R4

(Weake et al., 2008)

axon & photoreceptor cell R5

(Weake et al., 2008)

lamina anlage | precursor

(Martin et al., 1995)

larval inner optic anlage | precursor

(Martin et al., 1995)

larval outer optic anlage | precursor

(Martin et al., 1995)

photoreceptor cell R1 & axon

(Martin et al., 1995)

photoreceptor cell R2 & axon

(Martin et al., 1995)

photoreceptor cell R3 & axon

(Martin et al., 1995)

photoreceptor cell R4 & axon

(Martin et al., 1995)

photoreceptor cell R5 & axon

(Martin et al., 1995)

photoreceptor cell R6 & axon

(Martin et al., 1995)

Detailed Description

Statement

Reference

In not⁰²⁰⁶⁹ larvae, many R2-R5 axons fail to terminate in the lamina and instead project into the medulla.

(Weake et al., 2008)

Heterozygotes enhance the position effect variegation of w seen in the In(1)w^m4h chromosome.

(Zhao et al., 2008)

In hemizygotes R1-R6 neurons project through the lamina and terminate in the medulla. A few appear to stop in the lamina. In the developing optic ganglia the regions of the outer proliferation centre (OPC) and lamina precursor cells (LPC) are closer together and the shape of the inner proliferation centre (IPC) is oval rather than round.

(Martin et al., 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

not⁰²⁰⁶⁹/not[+] is a suppressor of visible | heat sensitive phenotype of peb¹

(Wilk et al., 2004)

Phenotype Manifest In

Suppressor of

Statement

Reference

not⁰²⁰⁶⁹/not[+] is a suppressor of eye | heat sensitive phenotype of peb¹

(Wilk et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

not^j4B8a

(BDGP Project Members, 1994-1999)

not^j9A6

(BDGP Project Members, 1994-1999)

not⁰⁶⁸⁰⁶

(BDGP Project Members, 1994-1999)

Rescued by

not⁰²⁰⁶⁹ is rescued by not^hs.PP

(Poeck et al., 2001)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

11553

P{PZ}not⁰²⁰⁶⁹ ry⁵⁰⁶/TM6B, Tb¹

Notes on Origin

Discoverer

A. Spradling.

Comments

Excision of the P{PZ} element can revert the phenotype.

(Poeck et al., 2001)

Complements: W⁰⁵⁰¹⁴. Complements: l(3)L3930^L3930. Complements: l(3)j13B3^j13B3. Complements: l(3)neo26¹.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

Not⁰²⁰⁶⁹

(Soffers et al., 2021)

l(3)02069

(Spradling et al., 1999)

l(3)02069⁰²⁰⁶⁹

(BDGP Project Members, 1994-1999)

non-stop⁰²⁰⁶⁹

(Li et al., 2017)

not⁰²⁰⁶⁹

(Cloud et al., 2019, Ma et al., 2016, Stegeman et al., 2016, Christensen et al., 2009.5.6, Christensen et al., 2008.4.15, Zhao et al., 2008)

not²

(Weake et al., 2008, Poeck et al., 2001, Salecker, 2001.3.5)

Name Synonyms

Secondary FlyBase IDs

FBal0044223

References (19)

Report Sections

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