FB2024_03 , released June 25, 2024
Allele: Dmel\RpS5a1
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General Information
Symbol
Dmel\RpS5a1
Species
D. melanogaster
Name
FlyBase ID
FBal0011878
Feature type
allele
Associated gene
Dmel\RpS5a
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
spontaneous
Progenitor genotype
Cytology
Description

Insertion of 6kb of unknown DNA.

(McKim et al., 1996)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  intrinsic cardiomyopathy
      CEA
      (Casad et al., 2011)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heterozygous RpS5a1 mutant females exhibit a dilated cardiomyopathy phenotype, including an increased end-systolic dimension (EDD) and a decreased fractional shortening (FS) compared to controls. Bristles appear short and thin compared to wild type (Minute phenotype).

      (Casad et al., 2011)

      Heterozygotes have shorter bristles than wild type flies. Eclosion is delayed by 35 hours.

      (Ferrus, 1975)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      RpS5a[+]/RpS5a1 is an enhancer of visible phenotype of Pi3K92ED954A.UAS.Tag:MYC, Scer\GAL4Bx-MS1096

      (Coelho et al., 2005)
      Other
      Statement
      Reference

      Delta1, RpS5a1 has lethal | dominant phenotype

      (Schultz, 1929)

      Dl[+]/Delta1, RpS5a1 has lethal | dominant phenotype

      (Schultz, 1929)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      RpS5a[+]/RpS5a1 is an enhancer of wing phenotype of Pi3K92ED954A.UAS.Tag:MYC, Scer\GAL4Bx-MS1096

      (Coelho et al., 2005)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Bridges, 24th Feb. 1924.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      M(1)15D1
      M(1)o
      (Ferrus, 1975)
      Mo
      (Schultz, 1929)
      RpS51
      (McKim et al., 1996)
      RpS5a1
      (Casad et al., 2011, Popodi et al., 2010-)
      Name Synonyms
      Secondary FlyBase IDs
        References (8)