FlyBase Allele Report: Dmel\mam[10]

General Information

Symbol

Dmel\mam¹⁰

Species

D. melanogaster

Name

FlyBase ID

FBal0012018

Feature type

allele

Associated gene

Dmel\mam

Associated Insertion(s)

Carried in Construct

Also Known As

mam^IL115

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Morcillo et al., 1996, Xu et al., 1990)

Mutagen

ethyl methanesulfonate

(Tearle and Nusslein-Volhard, 1987)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage | neurogenic phenotype | recessive

(Lehmann et al., 1983)

some die during embryonic stage | recessive

(Lehmann et al., 1983)

visible | recessive | somatic clone

(Helms et al., 1999)

Phenotype Manifest In

Detailed Description

Statement

Reference

Homozygous mutant follicle stem cell clones are present at a much lower frequency than control clones at 14 days (6% vs 46%) after clone induction.

(Vied and Kalderon, 2009)

Homozygous somatic clones produce bald patches in the notum missing microchaetae and can produce wing margin defects.

(Helms et al., 1999)

The RP2 motoneuron duplicated at the expense of the RP2sib. The aCC motoneuron is duplicated at the expense of the pCC interneuron. The Usib fates are duplicated at the expense of the U neurons. The dMP2 is duplicated at the expense of the vMP2. No change was observable in EL cell fate. This phenotype is the reciprocal of that shown for numb mutants. Mutant embryos show excess neuroblast formation characteristic of neurogenic mutants.

(Skeath and Doe, 1998)

No effect on the faf eye phenotype.

(Huang and Fischer-Vize, 1996)

Embryonic CNS exhibits severe disturbances and larval exhibit severe cuticle loss.

(Schmid et al., 1996)

Severe "abruptex" phenotype. Capable of rescuing the lethality conferred by all negatively complementing Ax heteroallelic combinations, individuals display an Ax, not wild type, phenotype.

(Xu et al., 1990)

Weak embryonic neurogenic phenotype.

(Lehmann et al., 1983)

Interacts with dx, in that the great majority of dx^ENU/Y; mam¹⁰/+ zygotes die as pupae (Xu and Artavanis-Tsakonas, 1990).

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

mam¹⁰ is a suppressor of lethal phenotype of N^Ax-9/N^Ax-E2

(Xu et al., 1990)

Phenotype Manifest In

Enhanced by

Statement

Reference

mam¹⁰ has phenotype, enhanceable by Su(H)¹⁶

(Fortini and Artavanis-Tsakonas, 1994)

mam¹⁰ has phenotype, enhanceable by Su(H)^O5

(Fortini and Artavanis-Tsakonas, 1994)

mam¹⁰ has phenotype, enhanceable by Su(H)^T4

(Fortini and Artavanis-Tsakonas, 1994)

Suppressor of

Statement

Reference

mam¹⁰/mam[+] is a suppressor of phenotype of hh^hs.PI

(Vied and Kalderon, 2009)

mam¹⁰/mam[+] is a suppressor of eye phenotype of N^spl-1

(Xu et al., 1990)

mam¹⁰/mam[+] is a suppressor of chaeta phenotype of N^spl-1

(Xu et al., 1990)

NOT Suppressor of

Statement

Reference

mam¹⁰ is a non-suppressor of phenotype of sno^71e3

(Coyle-Thompson and Banerjee, 1993)

Other

Statement

Reference

Su(dx)¹, dx^ENU, mam¹⁰/mam[+] has wing phenotype

(Busseau et al., 1994)

Su(dx)¹, dx^ENU, mam¹⁰/mam[+] has ocellus phenotype

(Busseau et al., 1994)

Su(dx)[+]/Su(dx)¹, dx^ENU, mam¹⁰/mam[+] has wing phenotype

(Busseau et al., 1994)

Su(dx)[+]/Su(dx)¹, dx^ENU, mam¹⁰/mam[+] has ocellus phenotype

(Busseau et al., 1994)

Su(dx)[+]/Su(dx)¹, dx^ENU, mam¹⁰ has wing phenotype

(Busseau et al., 1994)

Su(dx)[+]/Su(dx)¹, dx^ENU, mam¹⁰ has ocellus phenotype

(Busseau et al., 1994)

N^nd-2, mam¹⁰ has wing phenotype

(Xu et al., 1990)

Additional Comments

Genetic Interactions

Statement

Reference

The phenotype of excess follicle stem cell progeny in between egg chambers that is caused by expression of hh^hs.PI using heat shock twice daily for 3 days followed by a 3 day "chase" is dominantly suppressed by mam¹⁰, such that the number of inappropriate cells between egg chambers is strongly reduced.

(Vied and Kalderon, 2009)

Flies that are dx^ENU/Y; Su(dx)¹/+; mam¹⁰/+ are viable but display clear dx phenotypes in the ocelli and wings.

(Busseau et al., 1994)

Heterozygotes for mam¹⁰ also heterozygous for Su(H)^T4 or Su(H)¹⁶ show wing nicks.

(Fortini and Artavanis-Tsakonas, 1994)

There is no detectable dominant interaction with sno^71e3.

(Coyle-Thompson and Banerjee, 1993)

Severe loss of wing material phenotype when heterozygous with N^nd-1 or N^nd-2. Strong suppression of eye and bristle phenotype associated with N mutants.

(Xu et al., 1990)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (4)

Bloomington

51292

w^*; smo^D16 P{neoFRT}42D mam¹⁰/CyO, P{ActGFP}JMR1

51293

w^*; P{neoFRT}42D mam¹⁰ Egfr^f24/CyO, P{ActGFP}JMR1

51303

P{neoFRT}42D mam¹⁰ mago³/T(2;3)TSTL14, SM5: TM6B, Tb¹

51291

w^*; smo^D16 P{neoFRT}42D mam¹⁰ Egfr^f24/CyO, P{ActGFP}JMR1

Notes on Origin

Discoverer

Comments

Autosomal repressor.

(Xu et al., 1990)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

mam¹⁰

(Bhattacharya and Baker, 2009)

mam^IL115

(Vied and Kalderon, 2009, Johannes and Preiss, 2002, Helms et al., 1999, Nagel and Preiss, 1999, Go and Artavanis-Tsakonas, 1998, Skeath and Doe, 1998, Huang and Fischer-Vize, 1996, Morcillo et al., 1996, Schmid et al., 1996, Verheyen et al., 1996, Busseau et al., 1994, Fortini and Artavanis-Tsakonas, 1994, Coyle-Thompson and Banerjee, 1993, Xu and Artavanis-Tsakonas, 1990, Xu et al., 1990, Lehmann et al., 1983)

mam^IL1

(Tearle and Nusslein-Volhard, 1987)

Name Synonyms

Secondary FlyBase IDs

References (19)

Report Sections

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